Redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles: a folic acid mediated biocompatible cancer-targeted drug delivery system

2014 ◽  
Vol 2 (40) ◽  
pp. 7009-7016 ◽  
Author(s):  
Srivardhan Reddy Gayam ◽  
Shu-Pao Wu
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
System P ◽  
Redox Responsive ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Herein, redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles were designed for an effective cancer-targeted drug delivering system.

scholarly journals Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery System to Improve the Antitumor Effect of Paclitaxel

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoyan Xu ◽  
Chao Wu ◽  
Andi Bai ◽  
Xuan Liu ◽  
Huiling Lv ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Drug ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized MSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system for liver cancer chemotherapy.

Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery

2012 ◽  
Vol 2 (2) ◽  
pp. 281-286 ◽  
Author(s):  
Fabiola Porta ◽  
Gerda E. M. Lamers ◽  
Jess Morrhayim ◽  
Antonia Chatzopoulou ◽  
Marcel Schaaf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Drug

A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy

2018 ◽  
Vol 6 (28) ◽  
pp. 4618-4629 ◽  
Author(s):  
Lin Huang ◽  
Jia Liu ◽  
Fan Gao ◽  
Qian Cheng ◽  
Bo Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica ◽  
Targeted Drug Delivery System

A novel enzyme and redox dual-responsive targeted drug delivery system based on hollow mesoporous silica nanoparticles was developed for cancer therapy.

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