Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents

2014 ◽  
Vol 2 (37) ◽  
pp. 6397-6405 ◽  
Author(s):  
Maité Callewaert ◽  
Valérie Gaëlle Roullin ◽  
Cyril Cadiou ◽  
Elodie Millart ◽  
Laurence Van Gulik ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Gelation Process ◽  
Hydrogel Nanoparticles ◽  
Ionotropic Gelation ◽  
T2 Mri

A series of hydrogel nanoparticles incorporating MRI contrast agents (GdDOTP and MS325) as potential cross-linkers were elaborated by an easy and robust ionotropic gelation process.

scholarly journals Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents

Nanoscale ◽  
2015 ◽  
Vol 7 (23) ◽  
pp. 10519-10526 ◽  
Author(s):  
V. K. Sharma ◽  
A. Alipour ◽  
Z. Soran-Erdem ◽  
Z. G. Aykut ◽  
H. V. Demir
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
T2 Mri

We reported highly crystalline, monodisperse and low-magnetization magnetite nanocubes as potential dual-modal contrast agents exhibiting high longitudinal (r1 ∼ 5.23 mM−1 s−1) and transverse (r2 ∼ 89.68 mM−1 s−1) relaxivities.

Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents

2012 ◽  
Vol 124 (36) ◽  
pp. 9253-9256 ◽  
Author(s):  
Thomas Courant ◽  
Valérie Gaëlle Roullin ◽  
Cyril Cadiou ◽  
Maïté Callewaert ◽  
Marie Christine Andry ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient ◽  
T2 Mri

Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents

2012 ◽  
Vol 51 (36) ◽  
pp. 9119-9122 ◽  
Author(s):  
Thomas Courant ◽  
Valérie Gaëlle Roullin ◽  
Cyril Cadiou ◽  
Maïté Callewaert ◽  
Marie Christine Andry ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Highly Efficient ◽  
T2 Mri

scholarly journals Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T1-T2 MRI contrast agents

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tamilmani Vairapperumal ◽  
Ariya Saraswathy ◽  
Jayasree S. Ramapurath ◽  
Sreeram Kalarical Janardhanan ◽  
Nair Balachandran Unni
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
T2 Mri

scholarly journals Gd/Y Hydroxide Nanosheets as Highly Efficient T1/T2 MRI Contrast Agents

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Xin Li ◽  
Zhenhai Xue ◽  
Jinfeng Xia ◽  
Guohong Zhou ◽  
Danyu Jiang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Relaxation Times ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Force Microscopy ◽  
Highly Efficient ◽  
Transmission Electron ◽  
Magnetic Resonance Imaging Mri ◽  
Cytotoxicity Assessment ◽  
T2 Mri

To develop highly efficient T1/T2 magnetic resonance imaging (MRI) contrast agents (CAs), Gd/Y hydroxide nanosheets were synthesized by a simple exfoliation method from layer compounds using sodium polyacrylate (PAA) as a dispersant and stabilizer. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) results revealed the excellent performance of monolayer nanosheets with thicknesses of up to 1.5 nm. The MRI results of the T1 and T2 relaxation times showed that all of the Gd/Y hydroxide nanosheets have high longitudinal and transverse relaxivities (r1 and r2). In particular, the 10% Gd-LRH nanosheets exhibited excellent MRI performance (r1 = 103 mM−1 s−1, r2 = 372 mM−1 s−1), which is rarely reported. Based on the relationship between the structure of 10% Gd-LRH nanosheets and their MRI performances, and the highly efficient MRI of spaced Gd atoms in the nanosheets, a special model to explain the outstanding MRI performance of the 10% Gd-LRH nanosheets is suggested. The cytotoxicity assessment of the 10% Gd-LRH nanosheets, evaluated by CCK-8 assays on HeLa cells, indicated no significant cytotoxicity. This study presents a significant advancement in 2D nanomaterial MRI CA research, with Gd-doped nanosheets positioned as highly efficient T1/T2 MRI CA candidates.

Paramagnetic dysprosium oxide nanoparticles and dysprosium hydroxide nanorods as T2 MRI contrast agents

Biomaterials ◽  
2012 ◽  
Vol 33 (11) ◽  
pp. 3254-3261 ◽  
Author(s):  
Krishna Kattel ◽  
Ja Young Park ◽  
Wenlong Xu ◽  
Han Gyeol Kim ◽  
Eun Jung Lee ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Dysprosium Oxide ◽  
Mri Contrast ◽  
T2 Mri

scholarly journals Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents

2015 ◽  
pp. 3581 ◽  
Author(s):  
Slawomir Boncel ◽  
Nikodem Kuźnik ◽  
Marzena Wyskocka ◽  
Łukasz Przypis ◽  
Artur Herman ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
T2 Mri

Paramagnetic nanoparticle T1 and T2 MRI contrast agents

2012 ◽  
Vol 14 (37) ◽  
pp. 12687 ◽  
Author(s):  
Wenlong Xu ◽  
Krishna Kattel ◽  
Ja Young Park ◽  
Yongmin Chang ◽  
Tae Jeong Kim ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
T1 And T2 ◽  
T2 Mri
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