Hydrogels for tissue engineering and regenerative medicine

2014 ◽  
Vol 2 (33) ◽  
pp. 5319-5338 ◽  
Author(s):  
John A. Hunt ◽  
Rui Chen ◽  
Theun van Veen ◽  
Nicholas Bryan
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Water Content ◽  
Drug Carrier ◽  
High Water ◽  
High Water Content ◽  
Injectable Hydrogels ◽  
Surgical Implantation

Injectable hydrogels have become an incredibly prolific area of research in the field of tissue engineering and regenerative medicine, because of their high water content, mechanical similarity to natural tissues, and ease of surgical implantation, hydrogels are at the forefront of biomedical scaffold and drug carrier design.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

2010 ◽  
Vol 88 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
High Water ◽  
Delivery Systems ◽  
High Water Content ◽  
Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

scholarly journals Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3323 ◽  
Author(s):  
Somasundar Mantha ◽  
Sangeeth Pillai ◽  
Parisa Khayambashi ◽  
Akshaya Upadhyay ◽  
Yuli Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
3D Structure ◽  
Cell Immobilization ◽  
Decisive Role ◽  
High Water ◽  
Bioactive Molecules ◽  
High Water Content ◽  
Growth Factor Delivery ◽  
Tissue Engineering Scaffolds

The field of regenerative medicine has tremendous potential for improved treatment outcomes and has been stimulated by advances made in bioengineering over the last few decades. The strategies of engineering tissues and assembling functional constructs that are capable of restoring, retaining, and revitalizing lost tissues and organs have impacted the whole spectrum of medicine and health care. Techniques to combine biomimetic materials, cells, and bioactive molecules play a decisive role in promoting the regeneration of damaged tissues or as therapeutic systems. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, to provide mechanical support for the cells in the engineered tissues, and to simulate the native extracellular matrix. The high water content of hydrogels can provide an ideal environment for cell survival, and structure which mimics the native tissues. Hydrogel systems have been serving as a supportive matrix for cell immobilization and growth factor delivery. This review outlines a brief description of the properties, structure, synthesis and fabrication methods, applications, and future perspectives of smart hydrogels in tissue engineering.

An in situ poly(carboxybetaine) hydrogel for tissue engineering applications

2017 ◽  
Vol 5 (2) ◽  
pp. 322-330 ◽  
Author(s):  
Hsiu-Wen Chien ◽  
Jiashing Yu ◽  
Shing Tak Li ◽  
Hsin-Yu Chen ◽  
Wei-Bor Tsai
Keyword(s):  
Tissue Engineering ◽  
Water Content ◽  
Three Dimensional ◽  
High Water ◽  
Tissue Scaffolds ◽  
High Water Content ◽  
Engineering Applications

Hydrogels provide three-dimensional (3D) frames with tissue-like elasticity and high water content for tissue scaffolds.

Microwave-Induced Thermoacoustic Imaging for Embedded Explosives Detection in High-Water Content Medium

2019 ◽  
Vol 67 (7) ◽  
pp. 4803-4810 ◽  
Author(s):  
Xiong Wang ◽  
Tao Qin ◽  
Yexian Qin ◽  
Ahmed H. Abdelrahman ◽  
Russell S. Witte ◽  
...  
Keyword(s):  
Water Content ◽  
High Water ◽  
Explosives Detection ◽  
High Water Content ◽  
Thermoacoustic Imaging

scholarly journals Deep mantle melting, global water circulation and its implications for the stability of the ocean mass

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Shun-ichiro Karato ◽  
Bijaya Karki ◽  
Jeffrey Park
Keyword(s):  
Phase Transformation ◽  
Water Content ◽  
Sea Level ◽  
High Water ◽  
Water Circulation ◽  
Mantle Melting ◽  
High Water Content ◽  
Mineral Physics ◽  
Deep Mantle ◽  
Global Water

AbstractOceans on Earth are present as a result of dynamic equilibrium between degassing and regassing through the interaction with Earth’s interior. We review mineral physics, geophysical, and geochemical studies related to the global water circulation and conclude that the water content has a peak in the mantle transition zone (MTZ) with a value of 0.1–1 wt% (with large regional variations). When water-rich MTZ materials are transported out of the MTZ, partial melting occurs. Vertical direction of melt migration is determined by the density contrast between the melts and coexisting minerals. Because a density change associated with a phase transformation occurs sharply for a solid but more gradually for a melt, melts formed above the phase transformation depth are generally heavier than solids, whereas melts formed below the transformation depth are lighter than solids. Consequently, hydrous melts formed either above or below the MTZ return to the MTZ, maintaining its high water content. However, the MTZ water content cannot increase without limit. The melt-solid density contrast above the 410 km depends on the temperature. In cooler regions, melting will occur only in the presence of very water-rich materials. Melts produced in these regions have high water content and hence can be buoyant above the 410 km, removing water from the MTZ. Consequently, cooler regions of melting act as a water valve to maintain the water content of the MTZ near its threshold level (~ 0.1–1.0 wt%). Mass-balance considerations explain the observed near-constant sea-level despite large fluctuations over Earth history. Observations suggesting deep-mantle melting are reviewed including the presence of low-velocity anomalies just above and below the MTZ and geochemical evidence for hydrous melts formed in the MTZ. However, the interpretation of long-term sea-level change and the role of deep mantle melting in the global water circulation are non-unique and alternative models are reviewed. Possible future directions of studies on the global water circulation are proposed including geodynamic modeling, mineral physics and observational studies, and studies integrating results from different disciplines.

scholarly journals Torrefaction of Woody and Agricultural Biomass: Influence of the Presence of Water Vapor in the Gaseous Atmosphere

Processes ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 30
Author(s):  
María González Martínez ◽  
Estéban Hélias ◽  
Gilles Ratel ◽  
Sébastien Thiéry ◽  
Thierry Melkior
Keyword(s):  
Water Vapor ◽  
Water Content ◽  
Wheat Straw ◽  
Beech Wood ◽  
High Water ◽  
High Water Content ◽  
Biomass Degradation ◽  
Moist Atmosphere ◽  
Thermochemical Transformation ◽  
Degradation Reactions

Biomass preheating in torrefaction at an industrial scale is possible through a direct contact with the hot gases released. However, their high water-content implies introducing moisture (around 20% v/v) in the torrefaction atmosphere, which may impact biomass thermochemical transformation. In this work, this situation was investigated for wheat straw, beech wood and pine forest residue in torrefaction in two complementary experimental devices. Firstly, experiments in chemical regime carried out in a thermogravimetric analyzer (TGA) showed that biomass degradation started from lower temperatures and was faster under a moist atmosphere (20% v/v water content) for all biomass samples. This suggests that moisture might promote biomass components’ degradation reactions from lower temperatures than those observed under a dry atmosphere. Furthermore, biomass inorganic composition might play a role in the extent of biomass degradation in torrefaction in the presence of moisture. Secondly, torrefaction experiments on a lab-scale device made possible to assess the influence of temperature and residence time under dry and 100% moist atmosphere. In this case, the difference in solid mass loss between dry and moist torrefaction was only significant for wheat straw. Globally, an effect of water vapor on biomass transformation through torrefaction was observed (maximum 10%db), which appeared to be dependent on the biomass type and composition.

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