Blood activation and compatibility on single-molecular-layer biointerfaces

2014 ◽  
Vol 2 (30) ◽  
pp. 4911-4921 ◽  
Author(s):  
Shengqiang Nie ◽  
Hui Qin ◽  
Chong Cheng ◽  
Weifeng Zhao ◽  
Shudong Sun ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Molecular Layer ◽  
Artificial Organs ◽  
Living Systems ◽  
Tissue Cultures ◽  
Stem Cell Proliferation ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Single Molecular Layer

Research on the interactions between living systems and materials is fuelled by diverse biomedical needs, for example, drug encapsulation and stimulated release, stem cell proliferation and differentiation, cell and tissue cultures, as well as artificial organs.

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

2013 ◽  
Vol 52 (4) ◽  
pp. 633-650 ◽  
Author(s):  
Ismael Galve-Roperh ◽  
Valerio Chiurchiù ◽  
Javier Díaz-Alonso ◽  
Monica Bari ◽  
Manuel Guzmán ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cannabinoid Receptor ◽  
Receptor Signaling ◽  
Stem Cell Proliferation ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

scholarly journals MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

2010 ◽  
Vol 107 (5) ◽  
pp. 1876-1881 ◽  
Author(s):  
Chunnian Zhao ◽  
GuoQiang Sun ◽  
Shengxiu Li ◽  
Ming-Fei Lang ◽  
Su Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Cyclin D1 ◽  
Neural Stem Cell ◽  
Neural Differentiation ◽  
Stem Cell Proliferation ◽  
Neural Stem Cell Proliferation ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits increased expression during neural differentiation. However, the role of let-7b in neural stem cell proliferation and differentiation remains unknown. Here we show that let-7b regulates neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1. Overexpression of let-7b led to reduced neural stem cell proliferation and increased neural differentiation, whereas antisense knockdown of let-7b resulted in enhanced proliferation of neural stem cells. Moreover, in utero electroporation of let-7b to embryonic mouse brains led to reduced cell cycle progression in neural stem cells. Introducing an expression vector of Tlx or cyclin D1 that lacks the let-7b recognition site rescued let-7b-induced proliferation deficiency, suggesting that both TLX and cyclin D1 are important targets for let-7b-mediated regulation of neural stem cell proliferation. Let-7b, by targeting TLX and cyclin D1, establishes an efficient strategy to control neural stem cell proliferation and differentiation.

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