Facile synthesis of self-assembled spherical and mesoporous dandelion capsules of ZnO: efficient carrier for DNA and anti-cancer drugs

2014 ◽  
Vol 2 (25) ◽  
pp. 3956-3964 ◽  
Author(s):  
Vijay Bhooshan Kumar ◽  
Koushi Kumar ◽  
Aharon Gedanken ◽  
Pradip Paik
Keyword(s):  
Anticancer Drugs ◽  
Cancer Drugs ◽  
Facile Synthesis ◽  
Zno Nps ◽  
Anti Cancer ◽  
Self Assembled

Idiosyncratic self-assembled dandelion mesoporous capsules have been synthesized with ZnO NPs and NRs. The {(ZnO)nδ+–(DOX)m} and {(ZnO)nδ+–(DNA)m} complexes are very useful for delivery of anticancer drugs and genes, respectively.

Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

2011 ◽  
Vol 21 (9) ◽  
pp. 3100 ◽  
Author(s):  
Yong-Yong Li ◽  
Shou-Hu Hua ◽  
Wang Xiao ◽  
Hui-Yuan Wang ◽  
Xiao-Hua Luo ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Self Assembled

Anti-cancer drugs associated with sudden death and ventricular arrhythmias: a cardio-oncology pharmacovigilance analysis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Mirabel ◽  
P Karapetiantz ◽  
E Marijon ◽  
C Le Beller ◽  
Z Reda Al-Sayed ◽  
...  
Keyword(s):  
Sudden Death ◽  
Anticancer Drugs ◽  
Ventricular Arrhythmias ◽  
Lower Boundary ◽  
Individual Case ◽  
World Health ◽  
System Organ Class ◽  
Cancer Drugs ◽  
Drug Label ◽  
Anti Cancer

Abstract Background Experimental data have shown that some anticancer drugs can affect cardiac repolarization and induce life-threatening cardiac arrhythmias. Objective To identify anti-cancer drugs associated with the occurrence of sudden death (SD) and ventricular arrhythmias using the World Health Organization individual case safety report (ICSR) database, Vigibase. Methods The system organ class MEDRA was used to identify cases as ICSR with the terms sudden death, sudden cardiac death, cardiac arrest, ventricular fibrillation, ventricular tachycardia, ventricular arrhythmia and torsades de pointes (named as SD events) from Nov 1967 to Nov 2019. We used the ATC code L01 which regroups 219 antineoplastic agents. A disproportionality analysis was performed to estimate of relative Odds Ratio (ROR). Signals were considered significant when the lower boundary of the 99.97% confidence interval (ROR0.25) was ≥1. Results Among the 2,170,203 adverse events associated with anticancer drugs, 11,979 (0.55%) concerned SD events. A total of 49 molecules were significantly associated with SD events, among which 4 were withdrawn from market. These molecules were mainly anti-metabolites (20.0%), chemicals such as arsenic (17.8%,), anthracyclins (8.9%) and alkaloids (8.9%). When agents were grouped according to their mode of actions, the highest risks were observed for platinum-based drugs (n=1628 cases, ROR0.25=1.2) and anthracyclins (n=1323 cases, ROR0.25=1.3). While the risk for SD or severe arrhythmias was reported in the drug label for 29 agents (64.4%), we found that this risk was not identified or mentioned for 16 agents (35.5%). Conclusions We identified 49 anticancer drugs that are significantly associated with SD events overreporting. Appropriate monitoring and preventive measures should be considered for patients receiving these drugs. Funding Acknowledgement Type of funding source: None

scholarly journals Effects of Herbal Medicine Use on Adherence to Conventional Anticancer Drugs

2020 ◽  
pp. 1-20
Author(s):  
Christine Karungi ◽  
Philip Asiimwe ◽  
Conrad Ssentongo ◽  
Sharon Primah Tuhaise ◽  
Joseph Oloro
Keyword(s):  
Herbal Medicine ◽  
Cancer Patients ◽  
Anticancer Drugs ◽  
Herbal Medicines ◽  
Referral Hospital ◽  
Secondary Outcome ◽  
Cancer Drugs ◽  
Medicine Use ◽  
Regional Referral Hospital ◽  
Anti Cancer

Background: Use of herbal medicines alongside conventional anticancer drugs is common among cancer patients. This may potentially cause reduced adherence to conventional anti-cancer drugs, unpredictable side effects and unknown drug-herb interactions. This in the long run could result in poor clinical outcomes. Aim: This study was conducted to investigate how use of herbal medicines affects adherence to conventional anti-cancer drugs, to determine the proportion of patients using both conventional and herbal anticancer medicines and to identify the common herbal medicines used alongside conventional anti-cancer drugs by patients at the Mbarara Regional Referral Hospital Oncology unit. Methods and Findings: A cross-sectional study was conducted in the oncology clinic of Mbarara Regional Referral Hospital found in Mbarara district, Uganda. Data was collected between 20th March and 20th April 2019 from 122 participants who met the inclusion criteria with subsequent consenting. Our primary outcome was adherence and secondary outcome was to investigate whether cancer patients use herbal medicines alongside conventional anti-cancer drugs. Our study had 122 patients most of them belonging to the Banyankole tribe, 75 (61.5%) being males. Of the 72 (59.02%) patients who used herbal medicine, 40 (55.56%) were males and 66.67% of the herbal users reported relief from herbal medicines. Aloe Vera was the most commonly used herb. Most of the patients 77 (63.1%) showed high adherence, this was greater in the non-herbal users than in the herbal users (COR=1.62) though this was not significant (p=0.399). Conclusion: It is most likely that majority of cancer patients use at least one herb during their course of life. The results did not show a significant relationship between herbal medicine use and adherence to conventional anti-cancer drugs. The high proportion of herbal medicine users calls for more research into the area to provide further information that can help optimize cancer treatment outcomes.

scholarly journals Intravenous Immunoglobulin Suppresses Chemotherapy-induced Peripheral Neurotoxicity via Macrophage Modulation in Rats and Mice

2021 ◽  
Author(s):  
Jun Tanaka ◽  
Masahiko Kajii
Keyword(s):  
Intravenous Immunoglobulin ◽  
Anticancer Drugs ◽  
Suppressive Effect ◽  
Treatment Discontinuation ◽  
Cancer Drugs ◽  
Peripheral Neurotoxicity ◽  
Anti Cancer ◽  
Life Threatening ◽  
Novel Applications ◽  
Rats And Mice

Abstract Chemotherapy-induced peripheral neurotoxicity (CIPN) is a serious adverse effect that leads to treatment discontinuation by patients receiving anticancer therapy. Treatment discontinuation is a serious and life-threatening problem for patients with cancer; hence, there is a need for drugs that suppress the induction of CIPN by anticancer drugs. Intravenous immunoglobulin (IVIg) reportedly suppresses bortezomib-induced CIPN in a rat model. Here, using rodent models, we showed that IVIg can also suppress peripheral neurotoxicity induced by anticancer drugs other than bortezomib. Furthermore, the suppressive effect of IVIg disappeared when macrophages were depleted. These findings indicate two novel independent possibilities of alleviating CIPN using IVIg. First, CIPN can be controlled by macrophage modulation. Second, IVIg directly combined with anti-cancer drugs can avoid restrictions on the use of anti-cancer drugs due to CIPN inductions. However, further research is necessary for the bench-to-bedside translation of these novel applications of IVIg. Our findings lay a strong foundation for research on IVIg therapeutics.

scholarly journals Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs

RSC Advances ◽  
2018 ◽  
Vol 8 (66) ◽  
pp. 37905-37914 ◽  
Author(s):  
Imran Ali ◽  
Sofi Danish Mukhtar ◽  
Ming Fa Hsieh ◽  
Zeid A. Alothman ◽  
Abdulrahman Alwarthan
Keyword(s):  
Heterocyclic Compounds ◽  
Cancer Drugs ◽  
Facile Synthesis ◽  
Anti Cancer

Facile synthesis of micellar “nano” indole heterocyclic anti-cancer compounds is described.

scholarly journals Role of NRF2 cascade in determining the differential response of cervical cancer cells to anticancer drugs- an in vitro study

2021 ◽  
Author(s):  
Pushkal Sinduvadi Ramesh ◽  
Sharanya Raja ◽  
Shwethambari Harave Udayakumar ◽  
Shruthi Chandrashekar ◽  
Suma M Nataraj ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Enzyme Activity ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Differential Response ◽  
Cancer Drugs ◽  
Nrf2 Pathway ◽  
Siha Cells ◽  
Anti Cancer ◽  
Cervical Cancer Cells

Abstract Background Cervical cancers are usually treatable if detected in early stages by a combination of therapies. However, the prognosis of cervical cancer patients with metastasis remains unfavorable due to the fact that most of the cervical carcinomas are either resistant to anticancer drugs or show signs of relapse after initial treatment. Therefore, it is important to control the chemoresistance as it is the key to develop effective treatment options for cervical cancer. Objective The current study aimed at evaluating the differential responses of cervical cancer cells to anti-cancer drugs and assessed whether the differences in the expression profiles of antioxidant genes regulated by NRF2 (nuclear factor erythroid-2-related factor 2), led to the variations in the sensitivities of the cancer cells to treatment. Methodology: Three cervical cancer cell lines were investigated for their differences in NRF2 pathway by measuring the gene expression and enzyme activity. The differences in the sensitivity to anti-cancer drugs and variation in ROS profile was also evaluated. The addition of exogenous drugs to manipulate the intracellular ROS and its effect on NRF2 pathway genes was also investigated. Results HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 enzyme activity and basal GSH levels than C33A cells. Levels of ROS induced were higher in HeLa than C33A cells. Conclusion Overall, the differences in the cellular levels of antioxidant regulatory genes led to the differential response of cervical cancer cells to anti-cancer drugs.

Evaluation of anticancer drugs in NSCLC

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e14616-e14616
Author(s):  
H. M. Guirgis
Keyword(s):  
Anticancer Drugs ◽  
Cost Effective ◽  
Stage Ii ◽  
Phase Iii ◽  
Cancer Drugs ◽  
Scoring Model ◽  
Anti Cancer ◽  
Grading Scale ◽  
Corrected Ratio ◽  
Financial Relationships

e14616 Background: Methodology to evaluate anti-cancer drugs in GI malgnancies was previoulsy reported. It has been estimated that the society would be willing to pay $50,000-$100,000 per life-year S gain (S Negrier et, 2007). Objectives: Design scoring model methodology to evaluate and grade anti-cancer drugs in NSCLC with emphasis on the association between between S, AEs, A and C. Methodology: 0S and AEs data were abstracted from J Douillard, R Herbert, Le Chevalier, C Mangeold, A Sandler, F Shepard, R Rossell and C Thienelt (2005–2008). A was graded in points (P) from 3 oral to zero daily injections. AEs: 4 (placebo) to 0 (fatalities) using CTCAE v 3.0. S gain (days,d) was calculated in a corrected ratio of S/360 (SR); Cost R: as C/d/s/$1500, divided by (A+ AEs), corrected and expressed as C scores. C in US $ was based on treating one patient for entire course,70 kg or 1.7/ m2. Using a grading scale from A to D, Survival > 360d, SR>10; C/d/s up to $63 and CR up to 4.2 were rated as (A+) while S< 15d, SR <0.42, C/d/s> $1500 and CR>100 as (D). Results: Examples shown in Table . Adj Cis + Vin after resection in stage II and III scored the highest SR and lowest CR with A+ rating. However, there was a lesser SR using the same combination in mNSCLC. OS markedly improved with Er and BV in 2nd-line. Addition of Cetuximab (Cet) to Cis and Vin demonstrated modest S gain at a much higher CR. Bevacizumab (BV) combined with Pac + Car improved OS over Pac + Car in 1st and 2nd lines at higher CR. Combination of BV, Cis and Gemcitabine demonstrated the lowest S, highest CR and D rating. Discussion: S and C were calculated as Ratios. C scores were based on the association of S with arbitrary but relative weights assigned to AEs and A. BV and Er improved OS in 2nd line, in contrast to phase III Beta study. Adjuvant Cis+Vin seems to be cost-effective. Increased CR was not necessarily associated with improved S. Grading of drugs varied depending on S or C. Higher C/d/s, increased AEs and cumbersome A resulted in higher C scores. Conclusions: SR, CR and possibly C scores might be advantageous in evaluation, grading and comparison of anti-cancer drugs. [Table: see text] No significant financial relationships to disclose.

A Case of Malignant Melanoma Treated with a Combination of Anti-Cancer Drugs and Biological Response Modifiers.

1993 ◽  
Vol 55 (1) ◽  
pp. 43-46
Author(s):  
Jun YOSHIDA ◽  
Juichiro NAKAYAMA ◽  
Nobuyuki SHIMIZU ◽  
Shonosuke NAGAE ◽  
Yoshiaki HORI
Keyword(s):  
Malignant Melanoma ◽  
Biological Response ◽  
Biological Response Modifiers ◽  
Cancer Drugs ◽  
Anti Cancer
Sign in / Sign up

Export Citation Format

Share Document