scholarly journals Synthesis, characterization, in vitro phantom imaging, and cytotoxicity of a novel graphene-based multimodal magnetic resonance imaging-X-ray computed tomography contrast agent

2014 ◽  
Vol 2 (22) ◽  
pp. 3519-3530 ◽  
Author(s):  
Gaurav Lalwani ◽  
Joe Livingston Sundararaj ◽  
Kenneth Schaefer ◽  
Terry Button ◽  
Balaji Sitharaman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
X Ray ◽  
Ct Contrast Agent ◽  
X Ray Computed ◽  
Multimodal Mri ◽  
Ct Contrast

Development of a novel graphene-based multimodal MRI-CT contrast agent.

Dendrimers for theranostic applications

2015 ◽  
Vol 6 (3) ◽  
pp. 205-217 ◽  
Author(s):  
Ugir Hossain Sk ◽  
Chie Kojima
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Resonance Imaging ◽  
Multiple Functions ◽  
X Ray ◽  
Nuclear Medical Imaging ◽  
X Ray Computed ◽  
Theranostic Applications

AbstractRecently, there have been tremendous advances in the development of various nanotechnology-based platforms for diagnosis and therapy. These nanoplatforms, which include liposomes, micelles, polymers, and dendrimers, comprise highly integrated nanoparticles that provide multiple functions, such as targeting, imaging, and therapy. This review focuses on dendrimer-based nanocarriers that have recently been developed for ‘theranostics (or theragnosis)’, a combination of therapy and diagnostics. We discuss the in vitro and in vivo applications of these nanocarriers in strategies against diseases including cancer. We also explore the use of dendrimers as imaging agents for fluorescence imaging, magnetic resonance imaging, X-ray computed tomography, and nuclear medical imaging.

Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging

2014 ◽  
Vol 34 (3) ◽  
pp. 267-271
Author(s):  
Wei-Hung Liu ◽  
Yang-Kao Wang ◽  
Chi-Chang Wu ◽  
Win-Pin Deng ◽  
Kuang-Hsun Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Diagnostic Techniques ◽  
The Body ◽  
X Ray ◽  
Non Invasive ◽  
Ct Contrast Agent ◽  
X Ray Computed ◽  
Ct Contrast

Abstract X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications. Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation. Finally, the iohexol-cisplatin-gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery.

Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging

2020 ◽  
Vol 573 ◽  
pp. 278-286 ◽  
Author(s):  
Daniel González-Mancebo ◽  
Ana Isabel Becerro ◽  
Ariadna Corral ◽  
Sonia García-Embid ◽  
Marcin Balcerzyk ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
High Field ◽  
Dual Energy ◽  
Resonance Imaging ◽  
X Ray ◽  
X Ray Computed
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