Mesoporous silica nanoparticles for high capacity adsorptive desulfurization

2014 ◽  
Vol 2 (36) ◽  
pp. 14890-14895 ◽  
Author(s):  
Jessica M. Palomino ◽  
Dat T. Tran ◽  
Jesse L. Hauser ◽  
Hong Dong ◽  
Scott R. J. Oliver
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Adsorptive Desulfurization ◽  
First Time

Silver-loaded mesoporous silica nanoparticles were applied for the first time to the desulfurization of JP-8 fuel with record breaking performance.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

2018 ◽  
Vol 54 (84) ◽  
pp. 11921-11924 ◽  
Author(s):  
Yu Zhu ◽  
Wenhai Lin ◽  
Xin Wang ◽  
Wei Zhang ◽  
Li Chen ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bonds ◽  
Mesoporous Silica Nanoparticles ◽  
Passerini Reaction ◽  
One Pot ◽  
Nirf Imaging ◽  
First Time

For the first time, we have obtained a multifunctional nanoplatform (MSN-BDP-PEG) containing disulfide bonds, BODIPY 5 and PEG-CHO via a one-pot Passerini reaction for chemotherapy, phototherapy and NIRF imaging.

scholarly journals Strategies to Obtain Encapsulation and Controlled Release of Pentamidine in Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 195 ◽  
Author(s):  
Enrico Peretti ◽  
Ivana Miletto ◽  
Barbara Stella ◽  
Flavio Rocco ◽  
Gloria Berlier ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Type I ◽  
Pentamidine Isethionate ◽  
Kinetic Release ◽  
First Time ◽  
Severe Limit

Pentamidine (PTM), an antiprotozoal agent used in clinics as pentamidine isethionate salt (PTM-S), recently showed high potential also for the treatment of cancer and myotonic dystrophy type I. However, a severe limit to the systemic administration of PTM is represented by its nephrotoxicity, leading to the need for a system able to achieve a controlled release of the drug. In this study, mesoporous silica nanoparticles (MSNs) were employed for the first time to encapsulate PTM. PTM-S was first used for loading experiments into bare (MSN-OH) and aminopropyl, cyanopropyl and carboxypropyl-functionalized MSNs (MSN-NH2, MSN-CN and MSN-COOH respectively) but it was not adequately loaded in any MSNs. The free base of PTM (PTM-B) was then obtained from PTM-S and successfully loaded into MSNs. Specifically, MSN-COOH exhibited the highest loading capacity. In vitro evaluation of PTM-B kinetic release from the different MSNs was carried out. An influence of the functional groups in slowing the release of the drug, when compared to bare MSNs was observed. Altogether, these results demonstrate that MSN-COOH could be a promising system to achieve a controlled release of PTM.

Synthesis of yolk–shell mesoporous silica nanoparticles via a facile one-pot approach

2017 ◽  
Vol 53 (26) ◽  
pp. 3761-3764 ◽  
Author(s):  
Jing-Chuan Song ◽  
Fei-Fei Xue ◽  
Xing-Xing Zhang ◽  
Zhong-Yuan Lu ◽  
Zhao-Yan Sun
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Particles ◽  
One Pot ◽  
First Time

A simple and facile one-pot method is proposed for the fabrication of yolk–shell mesoporous silica particles for the first time and the particle size can be well controlled.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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