Tribological studies of some SAPS-free Schiff bases derived from 4-aminoantipyrine and aromatic aldehydes and their synergistic interaction with borate ester

2014 ◽  
Vol 2 (27) ◽  
pp. 10424-10434 ◽  
Author(s):  
Vinay Jaiswal ◽  
Kalyani Kalyani ◽  
Rashmi B. Rastogi ◽  
Rajesh Kumar
Keyword(s):  
Schiff Bases ◽  
Aromatic Aldehydes ◽  
Tribological Performance ◽  
Synergistic Interaction ◽  
Metal Free ◽  
Paraffin Oil ◽  
Borate Ester

Tribological performance of sulfur, phosphorous and metal-free Schiff bases and their synergistic formulations with borate ester in paraffin oil has been evaluated using a four-ball tester at optimized concentrations (1% w/v).

Synthesis, Characterization, Anti-proliferative Evaluation, and DNA Flow Cytometry Analysis of Some 2-Thiohydantoin Derivatives

2020 ◽  
Vol 20 (18) ◽  
pp. 1929-1941
Author(s):  
Heba A. Elhady ◽  
Hossa F. Al-Shareef
Keyword(s):  
Anticancer Activity ◽  
Schiff Bases ◽  
Anticancer Agents ◽  
Proliferative Activity ◽  
Cancer Cell Line ◽  
Aromatic Aldehydes ◽  
Pharmaceutical Chemistry ◽  
Dna Flow Cytometry ◽  
Quinazoline Derivative ◽  
Reference Drug

Background and Objective: Due to the well-documented anti-proliferative activity of 2-thiohydantoin incorporated with pyrazole, oxadiazole, quinazoline, urea, β-naphthyl carbamate and Schiff bases, they are noteworthy in pharmaceutical chemistry. Methods: An efficient approach for the synthesis of a novel series of 2-thiohydantoin derivatives incorporated with pyrazole and oxadiazole has proceeded via the reaction of the acyl hydrazide with chalcones and/or triethyl orthoformate. Schiff bases were synthesized by the reaction of the acyl hydrazide with different aromatic aldehydes. Moreover, Curtius rearrangement was applied to the acyl azide to obtain the urea derivative, quinazoline derivative, and carbamate derivative. Results: The synthesized compounds structures were discussed and confirmed depending on their spectral data. The anticancer activity of these heterocyclic compounds was evaluated against the breast cancer cell line (MCF-7), where they showed variable activity. Compound 5d found to have a superior anticancer activity, where it has (IC50 = 2.07 ± 0.13 μg/mL) in comparison with the reference drug doxorubicin that has (IC50 = 2.79 ± 0.07 μg / mL). Then compound 5d subjected to further studies such as cell cycle analysis and apoptosis. Apoptosis was confirmed by the upregulation of Bax, downregulation of Bcl-2, and the increase of the caspase 3/7percentage. Conclusion: Insertion of pyrazole, oxadiazole and, quinazoline moieties with 2-thiohydantoin moiety led to the enhancement of its anti-proliferative activity. Hence they can be used as anticancer agents.

scholarly journals Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4160
Author(s):  
Speranta Avram ◽  
Ana Maria Udrea ◽  
Diana Camelia Nuta ◽  
Carmen Limban ◽  
Adrian Cosmin Balea ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Neurodegenerative Disorders ◽  
Aromatic Aldehydes ◽  
Brain Disorders ◽  
Ir And Nmr Spectroscopy ◽  
Bioinformatics Tools ◽  
Ft Ir ◽  
New Treatments ◽  
New Compounds

(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents a bioinformatics and pathology study of new Schiff bases, (EZ)-N′-benzylidene-(2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide derivatives, and aims to evaluate the drug-like, pharmacokinetic, pharmacodynamic and pharmacogenomic properties, as well as to predict the binding to therapeutic targets by applying bioinformatics, cheminformatics and computational pharmacological methods. (3) Results: We obtained these Schiff bases by condensing (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanehydrazide with aromatic aldehydes, using the advantages of microwave irradiation. The newly synthesized compounds were characterized spectrally, using FT-IR and NMR spectroscopy, which confirmed their structure. Using bioinformatics tools, we noticed that all new compounds are drug-likeness features and may be proposed as potentially neuropsychiatric drugs (4) Conclusions: Using bioinformatics tools, we determined that the new compound 1e had a high potential to be used as a good candidate in neurodegenerative disorders treatment.

Synthesis of 2-Aryl-5-alkyl-fulleropyrrolidines: Metal-Free-Mediated Reaction of [60]Fullerene with Aromatic Aldehydes and Inactive Primary Amines

2017 ◽  
Vol 82 (16) ◽  
pp. 8617-8627 ◽  
Author(s):  
Meng Zhang ◽  
Hui-Juan Wang ◽  
Fa-Bao Li ◽  
Xin-Xin Zhong ◽  
Yong-Shun Huang ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
Metal Free

Anomeric effects in Schiff bases of D-glucosamine with aromatic aldehydes

1973 ◽  
Vol 19 (6) ◽  
pp. 1666-1668
Author(s):  
V. P. Panov ◽  
A. K. Trukhmanov ◽  
R. G. Zhbankov
Keyword(s):  
Schiff Bases ◽  
Aromatic Aldehydes ◽  
Anomeric Effects

Base-promoted aerobic oxidative synthesis of fused 1,3,5-triazines under metal-free conditions

2020 ◽  
Vol 22 (20) ◽  
pp. 6778-6782
Author(s):  
Jinjin Chen ◽  
Zhaozhao Sun ◽  
Fuhong Xiao ◽  
Guo-Jun Deng
Keyword(s):  
Aerobic Oxidation ◽  
Aromatic Aldehydes ◽  
Ammonium Iodide ◽  
Metal Free

An efficient base-promoted aerobic oxidation procedure for the synthesis of fused 1,3,5-triazines from 2-aminobenzimidazoles, aromatic aldehydes, and ammonium iodide under metal-free conditions has been developed.

ChemInform Abstract: A Formal Metal-Free N-Arylation via the Schmidt Reaction of Aromatic Aldehydes with an Azido Amine.

ChemInform ◽  
2013 ◽  
Vol 44 (26) ◽  
pp. no-no
Author(s):  
Peiming Gu ◽  
Jian Sun ◽  
Xiao-Yan Kang ◽  
Ming Yi ◽  
Xue-Qiang Li ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Schmidt Reaction ◽  
Metal Free

Metal-Free Methods in the Synthesis of Macrocyclic Schiff Bases

2007 ◽  
Vol 107 (1) ◽  
pp. 46-79 ◽  
Author(s):  
Nataliya E. Borisova ◽  
Marina D. Reshetova ◽  
Yuri A. Ustynyuk
Keyword(s):  
Schiff Bases ◽  
Metal Free

scholarly journals Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes

2006 ◽  
Vol 2006 ◽  
pp. 1-10 ◽  
Author(s):  
Ram K. Agarwal ◽  
Lakshman Singh ◽  
Deepak Kumar Sharma
Keyword(s):  
Schiff Bases ◽  
Room Temperature ◽  
Electrical Conductance ◽  
Aromatic Aldehydes ◽  
Transition Metal Ions ◽  
Biological Properties ◽  
Thermal Stabilities ◽  
Potential Activity ◽  
Antibacterial And Antifungal ◽  
Solid Complexes

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general compositionCuX2⋅(H2O)(L)(X = Cl, Br,NO3, NCS, orCH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.

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