scholarly journals Can adding oil control domain formation in binary amphiphile bilayers?

Soft Matter ◽  
2014 ◽  
Vol 10 (40) ◽  
pp. 7925-7931
Author(s):  
Martin J. Greenall ◽  
Carlos M. Marques
Keyword(s):  
Phase Separation ◽  
Domain Formation ◽  
Control Phase

The addition of oil to a mixed membrane is predicted to smooth the interface between the domains and could control phase separation.

scholarly journals Using optical tweezing to control phase separation and nucleation near a liquid–liquid critical point

Soft Matter ◽  
2019 ◽  
Vol 15 (41) ◽  
pp. 8279-8289
Author(s):  
Finlay Walton ◽  
Klaas Wynne
Keyword(s):  
Phase Separation ◽  
Critical Point ◽  
Control Phase

Laser-induced phase separation (LIPS) and LIPS and nucleation (LIPSaN) harness fluctuations near a liquid–liquid critical point using optical tweezing and underlie the process of nonphotochemical laser-induced nucleation (NPLIN).

Domain formation on curved membranes: phase separation or Turing patterns?

Soft Matter ◽  
2013 ◽  
Vol 9 (39) ◽  
pp. 9311 ◽  
Author(s):  
E. Orlandini ◽  
D. Marenduzzo ◽  
A. B. Goryachev
Keyword(s):  
Phase Separation ◽  
Turing Patterns ◽  
Domain Formation ◽  
Curved Membranes

Phase Separation and Fractal Domain Formation in Phospholipid/Diacetylene-Supported Lipid Bilayers

Langmuir ◽  
2007 ◽  
Vol 23 (21) ◽  
pp. 10661-10671 ◽  
Author(s):  
Jose M. Moran-Mirabal ◽  
Donald M. Aubrecht ◽  
Harold G. Craighead
Keyword(s):  
Phase Separation ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers ◽  
Domain Formation ◽  
Fractal Domain

scholarly journals The Effect of Transmembrane Protein Shape on Surrounding Lipid Domain Formation by Wetting

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 729 ◽  
Author(s):  
Molotkovsky ◽  
Galimzyanov ◽  
Batishchev ◽  
Akimov
Keyword(s):  
Phase Separation ◽  
Transmembrane Protein ◽  
Lipid Phase ◽  
Lipid Domains ◽  
Domain Formation ◽  
Cellular Membranes ◽  
Lipid Domain ◽  
Liquid Ordered ◽  
Lipid Environment ◽  
Protein Shape

Signal transduction through cellular membranes requires the highly specific and coordinated work of specialized proteins. Proper functioning of these proteins is provided by an interplay between them and the lipid environment. Liquid-ordered lipid domains are believed to be important players here, however, it is still unclear whether conditions for a phase separation required for lipid domain formation exist in cellular membranes. Moreover, membrane leaflets are compositionally asymmetric, that could be an obstacle for the formation of symmetric domains spanning the lipid bilayer. We theoretically show that the presence of protein in the membrane leads to the formation of a stable liquid-ordered lipid phase around it by the mechanism of protein wetting by lipids, even in the absence of conditions necessary for the global phase separation in the membrane. Moreover, we show that protein shape plays a crucial role in this process, and protein conformational rearrangement can lead to changes in the size and characteristics of surrounding lipid domains.

scholarly journals Phase-Separation and Domain-Formation in Cholesterol-Sphingomyelin Mixture: Pulse-EPR Oxygen Probing

2011 ◽  
Vol 101 (4) ◽  
pp. 837-846 ◽  
Author(s):  
Laxman Mainali ◽  
Marija Raguz ◽  
Witold K. Subczynski
Keyword(s):  
Phase Separation ◽  
Domain Formation ◽  
Pulse Epr

scholarly journals Phase Separation Drives Heterochromatin Domain Formation

2018 ◽  
Vol 114 (3) ◽  
pp. 445a ◽  
Author(s):  
Amy R. Strom ◽  
Alexander V. Emelyanov ◽  
Mustafa R. Mir ◽  
Dmitry V. Fyodorov ◽  
Xavier R. Darzacq ◽  
...  
Keyword(s):  
Phase Separation ◽  
Domain Formation ◽  
Heterochromatin Domain

scholarly journals Coupling Bulk Phase Separation of Disordered Proteins to Membrane Domain Formation in Molecular Simulations on a Bespoke Compute Fabric

Membranes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 17
Author(s):  
Julian C. Shillcock ◽  
David B. Thomas ◽  
Jonathan R. Beaumont ◽  
Graeme M. Bragg ◽  
Mark L. Vousden ◽  
...  
Keyword(s):  
Phase Separation ◽  
Intrinsically Disordered Proteins ◽  
Lipid Membrane ◽  
Molecular Simulations ◽  
Coarse Grained ◽  
Disordered Proteins ◽  
Computational Techniques ◽  
Domain Formation ◽  
Intrinsically Disordered ◽  
Ideal Mixing

Phospholipid membranes surround the cell and its internal organelles, and their multicomponent nature allows the formation of domains that are important in cellular signalling, the immune system, and bacterial infection. Cytoplasmic compartments are also created by the phase separation of intrinsically disordered proteins into biomolecular condensates. The ubiquity of lipid membranes and protein condensates raises the question of how three-dimensional droplets might interact with two-dimensional domains, and whether this coupling has physiological or pathological importance. Here, we explore the equilibrium morphologies of a dilute phase of a model disordered protein interacting with an ideal-mixing, two-component lipid membrane using coarse-grained molecular simulations. We find that the proteins can wet the membrane with and without domain formation, and form phase separated droplets bound to membrane domains. Results from much larger simulations performed on a novel non-von-Neumann compute architecture called POETS, which greatly accelerates their execution compared to conventional hardware, confirm the observations. Reducing the wall clock time for such simulations requires new architectures and computational techniques. We demonstrate here an inter-disciplinary approach that uses real-world biophysical questions to drive the development of new computing hardware and simulation algorithms.

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