scholarly journals Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification

2015 ◽  
Vol 6 (7) ◽  
pp. 3712-3717 ◽  
Author(s):  
Andrew M. Hartley ◽  
Athraa J. Zaki ◽  
Adam R. McGarrity ◽  
Cecile Robert-Ansart ◽  
Andriy V. Moskalenko ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Click Chemistry ◽  
Directed Assembly ◽  
Phenyl Azide ◽  
Functional Modulation

Designed phenyl azide incorporation combined with bioorthogonal Click chemistry to regulate enzyme activity, or promote its stable assembly on graphene.

Phospha-Scorpionate Complexes by Click Chemistry using Phenyl Azide and Ethynylphosphine Oxides

2008 ◽  
Vol 27 (13) ◽  
pp. 3210-3215 ◽  
Author(s):  
Sander G. A. van Assema ◽  
Cornelis G. J. Tazelaar ◽  
G. Bas de Jong ◽  
Jan H. van Maarseveen ◽  
Marius Schakel ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Phenyl Azide

Bis(pentafluorosulfanyl)phenyl Azide as an Expeditious Tool for Click Chemistry toward Antitumor Pharmaceuticals

ChemMedChem ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. 913-917 ◽  
Author(s):  
Yu-Dong Yang ◽  
Etsuko Tokunaga ◽  
Hidehiko Akiyama ◽  
Norimichi Saito ◽  
Norio Shibata
Keyword(s):  
Click Chemistry ◽  
Phenyl Azide

scholarly journals Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein

RSC Advances ◽  
2015 ◽  
Vol 5 (95) ◽  
pp. 77734-77738 ◽  
Author(s):  
Samuel C. Reddington ◽  
Sarunas Driezis ◽  
Andrew M. Hartley ◽  
Peter D. Watson ◽  
Pierre J. Rizkallah ◽  
...  
Keyword(s):  
Fluorescent Protein ◽  
Red Fluorescent Protein ◽  
Phenyl Azide ◽  
Functional Modulation

Genetically encoded incorporation of phenyl azide chemistry into the autofluorescent protein mCherry can be used to switch on or off fluorescence.

scholarly journals Correction: Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification

2016 ◽  
Vol 7 (6) ◽  
pp. 3936-3936
Author(s):  
Andrew M. Hartley ◽  
Athraa J. Zaki ◽  
Adam R. McGarrity ◽  
Cecile Robert-Ansart ◽  
Andriy V. Moskalenko ◽  
...  
Keyword(s):  
Directed Assembly ◽  
Functional Modulation

Correction for ‘Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification’ by Andrew M. Hartley et al., Chem. Sci., 2015, 6, 3712–3717.

Morphological and biochemical analyses of changes in rat hepatocytes related to wine and ethanol consumption

1984 ◽  
Vol 42 ◽  
pp. 232-233
Author(s):  
S.M. Geyer ◽  
C.L. Mendenhall ◽  
J.T. Hung ◽  
E.L. Cardell ◽  
R.L. Drake ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Endoplasmic Reticulum ◽  
Enzyme Activity ◽  
Malic Enzyme ◽  
Smooth Endoplasmic Reticulum ◽  
Rat Hepatocytes ◽  
Mature Male ◽  
Treatment Groups ◽  
Malic Enzyme Activity ◽  
Biochemical Analyses

Thirty-three mature male Holtzman rats were randomly placed in 3 treatment groups: Controls (C); Ethanolics (E); and Wine drinkers (W). The animals were fed synthetic diets (Lieber type) with ethanol or wine substituted isocalorically for carbohydrates in the diet of E and W groups, respectively. W received a volume of wine which provided the same gram quantity of alcohol consumed by E. The animals were sacrificed by decapitation after 6 weeks and the livers processed for quantitative triglycerides (T3), proteins, malic enzyme activity (MEA), light microscopy (LM) and electron microscopy (EM). Morphometric analysis of randomly selected LM and EM micrographs was performed to determine organellar changes in centrilobular (CV) and periportal (PV) regions of the liver. This analysis (Table 1) showed that hepatocytes from E were larger than those in C and W groups. Smooth endoplasmic reticulum decreased in E and increased in W compared to C values.

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Reductive light activation of enzyme activity

2000 ◽  
Vol 110 (3) ◽  
pp. 295-295
Author(s):  
Louise Anderson ◽  
Per Gardestrom
Keyword(s):  
Enzyme Activity ◽  
Light Activation
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