scholarly journals Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions

2015 ◽  
Vol 6 (7) ◽  
pp. 3823-3830 ◽  
Author(s):  
Johnson Lui-Lui Tsai ◽  
Taotao Zou ◽  
Jia Liu ◽  
Tianfeng Chen ◽  
Anna On-Yee Chan ◽  
...  
Keyword(s):  
Sustained Release ◽  
Self Assembly ◽  
Physiological Conditions ◽  
Emission Color ◽  
Anti Cancer ◽  
Ph Dependent

Luminescent platinum(ii) complexes show anti-cancer and pH-dependent self-assembly and sustained-release properties under physiological conditions.

scholarly journals Development of In Situ Self-Assembly Nanoparticles to Encapsulate Lopinavir and Ritonavir for Long-Acting Subcutaneous Injection

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 904
Author(s):  
Irin Tanaudommongkon ◽  
Asama Tanaudommongkon ◽  
Xiaowei Dong
Keyword(s):  
Sustained Release ◽  
Trough Concentration ◽  
Self Assembly ◽  
Subcutaneous Injection ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Long Acting

Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses. Here, a long-acting subcutaneous injection of lopinavir (LPV) in combination with ritonavir (RTV) using in situ self-assembly nanoparticles (ISNPs) was developed to potentially overcome adherence barriers. The ISNP approach can improve the pharmacokinetic profiles of the drugs. The ISNPs were characterized in terms of particle size, drug entrapment efficiency, drug loading, in vitro release study, and in vivo pharmacokinetic study. LPV/RTV ISNPs were 167.8 nm in size, with a polydispersity index of less than 0.35. The entrapment efficiency was over 98% for both LPV and RTV, with drug loadings of 25% LPV and 6.3% RTV. A slow release rate of LPV was observed at about 20% on day 5, followed by a sustained release beyond 14 days. RTV released faster than LPV in the first 5 days and slower than LPV thereafter. LPV trough concentration remained above 160 ng/mL and RTV trough concentration was above 50 ng/mL after 6 days with one subcutaneous injection. Overall, the ISNP-based LPV/RTV injection showed sustained release profiles in both in vitro and in vivo studies.

scholarly journals Alpha helical surfactant-like peptides self-assemble into pH-dependent nanostructures

Soft Matter ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. 3096-3104
Author(s):  
Valeria Castelletto ◽  
Jani Seitsonen ◽  
Janne Ruokolainen ◽  
Ian W. Hamley
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Small Angle ◽  
Self Assembly ◽  
X Ray ◽  
Cryogenic Transmission Electron Microscopy ◽  
X Ray Scattering ◽  
Transmission Electron ◽  
Ph Dependent ◽  
Ray Scattering

A designed surfactant-like peptide is shown, using a combination of cryogenic-transmission electron microscopy and small-angle X-ray scattering, to have remarkable pH-dependent self-assembly properties.

pH-dependent self-assembly of copper(II) complexes with a new imidazole-containing polyamine ligand: Synthesis, structure and magnetic property

Polyhedron ◽  
2008 ◽  
Vol 27 (12) ◽  
pp. 2672-2680 ◽  
Author(s):  
Zhao-Peng Qi ◽  
Zheng-Shuai Bai ◽  
Qing Yuan ◽  
Taka-aki Okamura ◽  
Kai Cai ◽  
...  
Keyword(s):  
Magnetic Property ◽  
Self Assembly ◽  
Ph Dependent ◽  
Ligand Synthesis

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

pH-Dependent In-Cell Self-Assembly of Peptide Inhibitors Increases the Anti-Prion Activity While Decreasing the Cytotoxicity

2017 ◽  
Vol 18 (3) ◽  
pp. 943-950 ◽  
Author(s):  
Muhammad Waqas ◽  
Woo-jin Jeong ◽  
Young-Joo Lee ◽  
Dae-Hwan Kim ◽  
Chongsuk Ryou ◽  
...  
Keyword(s):  
Self Assembly ◽  
Peptide Inhibitors ◽  
Ph Dependent

scholarly journals Self-Assembly, Tunable Hydrogel Properties, and Selective Anti-Cancer Activity of a Carnosine-Derived Lipidated Peptide

2019 ◽  
Vol 11 (37) ◽  
pp. 33573-33580 ◽  
Author(s):  
Valeria Castelletto ◽  
Charlotte J. C. Edwards-Gayle ◽  
Francesca Greco ◽  
Ian W. Hamley ◽  
Jani Seitsonen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Melanin production by tyrosinase activity on a tyrosine-rich peptide fragment and pH-dependent self-assembly of its lipidated analogue

2019 ◽  
Vol 17 (18) ◽  
pp. 4543-4553 ◽  
Author(s):  
Jessica A. Hutchinson ◽  
Ian W. Hamley ◽  
Charlotte J. C. Edwards-Gayle ◽  
Valeria Castelletto ◽  
Cristian Piras ◽  
...  
Keyword(s):  
Self Assembly ◽  
Tyrosinase Activity ◽  
The Self ◽  
Peptide Fragment ◽  
Melanin Production ◽  
Gut Hormone ◽  
Ph Dependent

The self-assembly of a palmitoylated peptide C16-EELNRYY based on a fragment of the gut hormone peptide PYY3–36 is investigated.

Nuclear delivery of dual anti-cancer drugs by molecular self-assembly

2021 ◽  
Vol 9 (1) ◽  
pp. 116-123
Author(s):  
Jindao Wu ◽  
Wenzhou Ding ◽  
Guoyong Han ◽  
Wei You ◽  
Wen Gao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Tumor Cells ◽  
Self Assembly ◽  
Nuclear Accumulation ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Good Cell

Nanomedicines generally suffer from poor accumulation in tumor cells, low anti-tumor efficacy, and drug resistance. In order to address these problems, we introduced a novel nanomedicine based on dual anti-cancer drugs, which showed good cell nuclear accumulation properties.

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