PCL/PVA nanoencapsulated reinforcing fillers of steam exploded/autoclaved cellulose nanofibrils for tissue engineering applications

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 23999-24008 ◽  
Author(s):  
Navdeep Manhas ◽  
K. Balasubramanian ◽  
P. Prajith ◽  
Prashant Rule ◽  
Sunil Nimje

The process of extraction of cellulose nanofibrils by steam explosion followed by electrospinning with biodegradable polymers to yield PCL/PVA nanoencapsulated cellulosic reinforcing fillers for tissue engineering applications.

Author(s):  
Joao S. Soares ◽  
James E. Moore ◽  
Kumbakonam R. Rajagopal

Synthetic biodegradable polymers have seen a dramatic increase in their availability and utilization over the last few decades. The first reported biomedical application of biodegradable polymers was during the 70s in biodegradable sutures and to date, it remains as the most widespread usage of this family of materials. Biodegradable polymers have also been proven to be effective carriers in local drug delivery therapies and are widely used as a primary constituent of scaffolds in tissue engineering applications.


Author(s):  
Marzieh Monfared ◽  
Damia Mawad ◽  
Jelena Rnjak-Kovacina ◽  
Martina Heide Stenzel

Hydrogels based on cellulose nanofibrils (CNFs) have been widely used as scaffolds for biomedical applications, however, the poor mechanical properties of CNFs hydrogels limit their use as ink for 3D...


2020 ◽  
Vol 4 (4) ◽  
pp. 152
Author(s):  
Ali Mirtaghavi ◽  
Jikui Luo ◽  
Rajendran Muthuraj

Current approaches in developing porous 3D scaffolds face various challenges, such as failure of mimicking extracellular matrix (ECM) native building blocks, non-sustainable scaffold fabrication techniques, and lack of functionality. Polysaccharides and proteins are sustainable, inexpensive, biodegradable, and biocompatible, with structural similarities to the ECM. As a result, 3D-structured cellulose (e.g., cellulose nanofibrils, nanocrystals and bacterial nanocellulose)-based aerogels with high porosity and interconnected pores are ideal materials for biomedical applications. Such 3D scaffolds can be prepared using a green, scalable, and cost-effective freeze-drying technique. The physicochemical, mechanical, and biological characteristics of the cellulose can be improved by incorporation of proteins and other polysaccharides. This review will focus on recent developments related to the cellulose-based 3D aerogels prepared by sustainable freeze-drying methods for tissue engineering applications. We will also provide an overview of the scaffold development criteria; parameters that influenced the aerogel production by freeze-drying; and in vitro and in vivo studies of the cellulose-based porous 3D aerogel scaffolds. These efforts could potentially help to expand the role of cellulose-based 3D scaffolds as next-generation biomaterials.


Biomaterials ◽  
2004 ◽  
Vol 25 (19) ◽  
pp. 4683-4690 ◽  
Author(s):  
E Leclerc ◽  
K.S Furukawa ◽  
F Miyata ◽  
Y Sakai ◽  
T Ushida ◽  
...  

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