Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14482-14491 ◽  
Author(s):  
DaeYong Lee ◽  
Kibaek Choe ◽  
YongJun Jeong ◽  
Jisang Yoo ◽  
Sung Mun Lee ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Insulin Release ◽  
Delivery System ◽  
Insulin Delivery ◽  
Glycol Chitosan ◽  
Glucose Levels ◽  
Insulin Delivery System

Glucose-responsive glycol chitosan/sodium alginate-poly(l-glutmate-co-N-3-l-glutamylphenylboronic acid) double-layered nanogel is a promising platform for controlled insulin release systems, achieving glucose-triggered insulin release at diabetic glucose levels in vivo.

In Vivo Evaluation of a Nasal Insulin Delivery System Based on Thiolated Chitosan

2006 ◽  
Vol 95 (11) ◽  
pp. 2463-2472 ◽  
Author(s):  
Alexander H. Krauland ◽  
Verena M. Leitner ◽  
Vjera Grabovac ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Insulin Delivery System

scholarly journals Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2499
Author(s):  
Francivandi Coelho Barbosa ◽  
Milena Costa da Silva ◽  
Henrique Nunes da Silva ◽  
Danyllo Albuquerque ◽  
Allyson Antônio Ribeiro Gomes ◽  
...  
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
Patient Comfort ◽  
Alternative Form ◽  
Release Times ◽  
Macromolecular Drugs ◽  
Insulin Delivery System ◽  
Automated Support

Diabetes mellitus is a chronic disease that is considered a worldwide epidemic, and its control is a constant challenge for health systems. Since insulin had its first successful use, scientists have researched to improve the desired effects and reduce side-effects. Over the years, the challenge has been to increase adherence to treatment and improve the quality of life for diabetics by developing an insulin delivery system. This systematic review (SR) analyses experimental articles from 1998 to 2018 related to the development of the chitosan/insulin delivery system (CIDS). Automated support: Start tool was used to perform part of these activities. The search terms “insulin”, “delivery or release system”, and “chitosan” were used to retrieve articles in PubMed, Science Direct, Engineering Village, and HubMed. A total of 55 articles were selected. The overview, phase, model, way of administration, and the efficiency of CIDS were analyzed. According to SR results, most of the articles were published from 2010 onwards, representing 72.7% of the selected papers, and research groups from China publicized 23.6% of the selected articles. According to the SR, 51% of the studies were carried out in vivo and 45% in vitro. Most of the systems were nanoparticle based (54.8%), and oral administration was proposed by 60.0% of the selected articles. Only 36.4% performed loaded capacity and encapsulation efficiency assays, and 24 h (16.4%), 12 h (12.7%), and 6 h (11.0%) were the most frequent insulin release times. Chitosan’s intrinsic characteristics, which include biodegradability, biocompatibility, adhesiveness, the ability to open epithelial tight junctions to allow an increase in the paracellular transport of macromolecular drugs, such as insulin, and the fact that it does not result in allergic reactions in the human body after implantation, injection, topical application or ingestion, have contributed to the increase in research of CIDS over the years. However, the number of studies is still limited and the use of an alternative form of insulin administration is not yet possible. Thus, more studies in this area, aiming for the development of an insulin delivery system that can promote more adherence to the treatment and patient comfort, are required.

scholarly journals Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Akira Matsumoto ◽  
Hirohito Kuwata ◽  
Shinichiro Kimura ◽  
Hiroko Matsumoto ◽  
Kozue Ochi ◽  
...  
Keyword(s):  
Delivery System ◽  
Hollow Fiber ◽  
Insulin Delivery ◽  
Free Insulin ◽  
Insulin Delivery System

A self-regulating insulin delivery system. II. In vivo characteristics of a synthetic glycosylated insulin

1989 ◽  
Vol 54 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Leah A. Seminoff ◽  
Jeremy M. Gleeson ◽  
Jiang Zheng ◽  
Gary B. Olsen ◽  
David Holmberg ◽  
...  
Keyword(s):  
Delivery System ◽  
Insulin Delivery ◽  
Insulin Delivery System

In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

2010 ◽  
Vol 99 (10) ◽  
pp. 4215-4227 ◽  
Author(s):  
M. Joan Taylor ◽  
Sangeeta Tanna ◽  
Tarsem Sahota
Keyword(s):  
Delivery System ◽  
Rat Model ◽  
Insulin Delivery ◽  
In Vivo Study ◽  
Insulin Delivery System

1065-P: The Effect of a Closed-Loop Insulin Delivery System on Glycemic Control in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1065-P ◽  
Author(s):  
ANASTASIOS KOUTSOVASILIS ◽  
ALEXIOS SOTIROPOULOS ◽  
ANASTASIA ANTONIOU ◽  
VASILIOS KORDINAS ◽  
DESPINA PAPADAKI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Delivery System ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Insulin Delivery System

Well-defined degradable brush-coil block copolymers for intelligent release of insulin at physiological pH

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21486-21496 ◽  
Author(s):  
Xuan Zhang ◽  
Liyuan Zhao ◽  
Junjiao Yang ◽  
Jing Yang
Keyword(s):  
Block Copolymers ◽  
Delivery System ◽  
Side Effect ◽  
Insulin Delivery ◽  
Brush Polymer ◽  
Insulin Delivery System ◽  
Grafting From

To achieve an intelligent insulin delivery system with minimal long-term side effect, a kind of brush polymer was synthesized through poly[(2-phenylborate esters-1,3-dioxane-5-ethyl)methylacrylate] grafting from the backbone poly(ε-caprolactone).

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