scholarly journals Preparing mono-dispersed liquid core PDMS microcapsules from thiol–ene–epoxy-tailored flow-focusing microfluidic devices

RSC Advances ◽  
2015 ◽  
Vol 5 (20) ◽  
pp. 15379-15386 ◽  
Author(s):  
P. Mazurek ◽  
A. E. Daugaard ◽  
M. Skolimowski ◽  
S. Hvilsted ◽  
A. L. Skov
Keyword(s):  
Click Chemistry ◽  
Material Properties ◽  
Liquid Core ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
Flow Focusing

A dual-cure system based on thiol–ene and thiol–epoxy “click chemistry” reactions proved to be an effective and easy to use tool for microfluidic chips, which provides control over material properties and enables covalently bonding of chip wafers.

scholarly journals Strategy for fast manufacturing of 3D hydrodynamic focusing multilayer microfluidic chips and its application for flow-based synthesis of gold nanoparticles

2021 ◽  
Vol 25 (8) ◽  
Author(s):  
Yanwei Wang ◽  
Michael Seidel
Keyword(s):  
Gold Nanoparticles ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
Proof Of Concept ◽  
Hydrodynamic Focusing ◽  
Pressure Sensitive Adhesive ◽  
Pmma Sheet ◽  
Pressure Sensitive ◽  
Working Device ◽  
Channel Structures

AbstractFabrication of 3D microfluidic devices is normally quite expensive and tedious. A strategy was established to rapidly and effectively produce multilayer 3D microfluidic chips which are made of two layers of poly(methyl methacrylate) (PMMA) sheets and three layers of double-sided pressure sensitive adhesive (PSA) tapes. The channel structures were cut in each layer by cutting plotter before assembly. The structured channels were covered by a PMMA sheet on top and a PMMA carrier which contained threads to connect with tubing. A large variety of PMMA slides and PSA tapes can easily be designed and cut with the help of a cutting plotter. The microfluidic chip was manually assembled by a simple lamination process.The complete fabrication process from device design concept to working device can be completed in minutes without the need of expensive equipment such as laser, thermal lamination, and cleanroom. This rapid frabrication method was applied for design of a 3D hydrodynamic focusing device for synthesis of gold nanoparticles (AuNPs) as proof-of-concept. The fouling of AuNPs was prevented by means of a sheath flow. Different parameters such as flow rate and concentration of reagents were controlled to achieve AuNPs of various sizes. The sheet-based fabrication method offers a possibility to create complex microfluidic devices in a rapid, cheap and easy way.

scholarly journals Development of Epoxy Resin-Based Elastomeric Microfluidic Devices Using CO2 Laser Ablation for DNA-Amplification Point-Of-Care (POC) Applications: Assessment of Microchannels' Dimensions and Quality

2021 ◽  
Author(s):  
Heba Mansour ◽  
Ahmed M.R. Fath El-Bab ◽  
Emad A. Soliman ◽  
Ahmed L. Abdel-Mawgood
Keyword(s):  
Laser Ablation ◽  
Epoxy Resin ◽  
Epoxy Resins ◽  
Carbon Dioxide Laser ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
Laser Technique ◽  
Lab On Chip ◽  
Expensive Equipment ◽  
The Impact

Abstract Microfluidic devices are a rising technology to automatize chemical and biological operations. In this context, laser ablation has significant potential for polymer-based microfluidic platforms' fast and economical manufacturing. Nevertheless, the manufacturing of epoxy-based microfluidic chips is considered highly cost full due to demand for cleanroom facilities that utilize expensive equipment and lengthy processes. Therefore, this study targeted investigating the feasibility of epoxy resins to be fabricated as a lab-on-chip using carbon dioxide laser ablation. The chemical structural properties and thermal stability of the plain epoxy resins were characterized by Fourier transform infrared spectral analysis (FT-IR) and thermogravimetric analysis (TGA). Moreover, a specific migration test was performed to quantify potential migrants by gas chromatography coupled to mass spectrometry (GC-MS) to prove that the cured epoxy resin would not release unreacted monomers to the biological solution test, which caused inhibition of the sensitive biological reactions. By investigating the impact of this process on microchannels' dimensions and quality, a laser technique using CO2 laser was used in vector mode to engrave into a transparent epoxy resin chip. The resulting microchannels were characterized using 3D Laser microscopy. The outcomes of this study showed considerable potential for laser ablation in machining the epoxy-based chips, whereas the microchannels were produced with minor bulges' height (0.027 µm) with no clogging. Moreover, a reasonable depth of 99.31 µm with roughness (Ra) of 14.52 µm was obtained at a laser speed of 5 mm/s and laser power of 1.8 W. This process can produce epoxy resin-based microfluidic chips without the need for cleanroom facilities that require expensive equipment and lengthy process.

Design, characterization and application of a novel mono-layer pin-microvalve for microfluidic devices

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24394-24398 ◽  
Author(s):  
Mahyar Nasabi ◽  
Masoomeh Tehranirokh ◽  
Francisco Javier Tovar-Lopez ◽  
Abbas Kouzani ◽  
Khashayar Khoshmanesh ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Hydrodynamic Flow ◽  
Flow Focusing ◽  
Mono Layer

We introduce a novel manual pin-valve which can operate in both analogue (partially close) and digital (on/off) states. We also demonstrate implementation of this pin-valve in a hydrodynamic flow focusing (HFF) device.

scholarly journals Coaxial flow focusing in poly(dimethylsiloxane) microfluidic devices

2014 ◽  
Vol 8 (1) ◽  
pp. 016502 ◽  
Author(s):  
Tuan M. Tran ◽  
Sean Cater ◽  
Adam R. Abate
Keyword(s):  
Microfluidic Devices ◽  
Flow Focusing

Reliable and reusable whole polypropylene plastic microfluidic devices for a rapid, low-cost antimicrobial susceptibility test

Lab on a Chip ◽  
2019 ◽  
Vol 19 (17) ◽  
pp. 2915-2924 ◽  
Author(s):  
Han Sun ◽  
Chiu-Wing Chan ◽  
Yisu Wang ◽  
Xiao Yao ◽  
Xuan Mu ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Practical Method ◽  
Susceptibility Test ◽  
Microfluidic Chips ◽  
Antimicrobial Susceptibility Test ◽  
Commercial Use

Using an antimicrobial susceptibility test (AST) as an example, this work demonstrates a practical method to fabricate microfluidic chips entirely from polypropylene (PP) and the benefits for potential commercial use.

Fab in a Package: LTCC Microfluidic Devices for Micro and Nanoparticle Fabrication

2012 ◽  
Vol 2012 (CICMT) ◽  
pp. 000294-000302
Author(s):  
Mário Ricardo Gongora-Rubio ◽  
Kellen Heloizy Garcia Freitas ◽  
Juliana de Novais Schianti ◽  
Adriano Marim de Oliveira ◽  
Natália Neto Pereira Cerize ◽  
...  
Keyword(s):  
Energy Use ◽  
Microfluidic Devices ◽  
Chemical Processes ◽  
Mass Transportation ◽  
Flow Focusing ◽  
Automated Control ◽  
Microreaction Technology ◽  
Relevant Role ◽  
Excellent Control ◽  
Nanoparticle Fabrication

The chemical industry is moving toward miniaturization with the help of microreaction technology and automated control systems. Besides the evident advantages of Microtechnology like improved portability, reduced energy use, safety and flexibility, the main advantage associated with the miniaturization of chemical processes is the increased microreactor control due to predictable thermal and mass transportation properties. We understand that LTCC Microsystem technology have a relevant role in this area. LTCC Microfluidic devices have been applied to carry out several chemical processes operations, including mixing, separation, chemical reactions, heterogeneous catalysis, heat exchange and so on. More recently, LTCC microfluidic systems have also been used to produce micro- and nanoparticles with excellent control of size distribution, morphology and constitution. The present work give an account of some LTCC Microfluidic devices aimed for Micro and Nanoparticle fabrication. At this time we report devices for: Emulsion generation for obtaining alginate microparticles by ionic gelation; Electrospinning applications, Microreactors for silver nanoparticle production and 3D Flow focusing devices for pharmaceutical active nanocrystallization.

scholarly journals Formation of core-shell droplets for the encapsulation of liquid contents

2021 ◽  
Author(s):  
Fariba Malekpour Galogahi ◽  
Yong Zhu ◽  
Hongjie An ◽  
Nam-Trung Nguyen
Keyword(s):  
Microfluidic Device ◽  
Liquid Core ◽  
Core Shell ◽  
Flow Focusing ◽  
The Core ◽  
Liquid Phases ◽  
Optical Electron ◽  
Computed Microtomography ◽  
Shell Particles ◽  
High Degree

Abstract Accurate control of monodisperse core-shell droplets generated in a microfluidic device has a broad range of applications in research and industry. This paper reports the experimental investigation of flow-focusing microfluidic devices capable of producing size-tuneable and monodisperse core-shell droplets. The dimension of the core-shell droplets was controlled passively by the channel geometry and the flow rate of the liquid phases. The results indicate that microchannel geometry is more significant than flow rates. The highly controllable core-shell droplets could be subsequently employed as a template for generating core-shell micropaticles with liquid core. Optical, electron microscopy and X-ray computed microtomography showed that the geometry of the core-shell droplets remains unchanged after solidification, drying and collection. The present study also looks at the thermal stability of core-shell particles depending on the particle size. The larger core-shell partcles with a thicker shell provide a higher resistance to heating at elevated temperature. The high degree of control with a flow-focusing microfluidic device makes this a promising approach for the encapsulation, storage, and delivery of lipophilic contents.

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