Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines

RSC Advances ◽  
2015 ◽  
Vol 5 (5) ◽  
pp. 3491-3497 ◽  
Author(s):  
Yanling Dai ◽  
Chen Xie ◽  
Lingmin Wu ◽  
Haibo Mei ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Mannich Reactions ◽  
Unknown Type ◽  
Derivatives Of

We reported the asymmetric Mannich reactions between lithium-benzothiazoles and (S)-N-tert-butanesulfinylketimines, which gave unknown type of amino-benzothiazol derivatives of high pharmaceutical potential with up to 96% yields and 99 : 1 diastereoselectivities.

Asymmetric Synthesis of α‐Difluorinated β‐Amino Sulfones via Detrifluoroacetylative Mannich Reactions

2021 ◽  
Author(s):  
Ziyi Li ◽  
Nana Wang ◽  
Haibo Mei ◽  
Hiroyuki Konno ◽  
Vadim A. Soloshonok ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Mannich Reactions

Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

2020 ◽  
Vol 56 (1) ◽  
pp. 98-101 ◽  
Author(s):  
Xueqian Ye ◽  
Yongkai Pan ◽  
Xiaoyu Yang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Synthesis ◽  
Cyclic Ketones ◽  
Mannich Reactions ◽  
Chiral Phosphoric Acid ◽  
Quaternary Stereocenter

Herein, we report the asymmetric synthesis of chiral azides possessing an α-quaternary stereocenter via chiral phosphoric acid catalysed direct enantioselective Mannich reactions of α-azido cyclic ketones with aldimines.

ChemInform Abstract: Alkylation and Aldol Reactions of Acyl Derivatives of N-1-(1′-Naphthyl)ethyl-O-tert-butylhydroxylamine: Asymmetric Synthesis of α-Alkoxy-, α-Substituted-β-alkoxy- and α,β-Dialkoxyaldehydes.

ChemInform ◽  
2010 ◽  
Vol 41 (39) ◽  
pp. no-no
Author(s):  
Alexander N. Chernega ◽  
Stephen G. Davies ◽  
Ai M. Flechter ◽  
Christopher J. Goodwin ◽  
David Hepworth ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Aldol Reactions ◽  
Derivatives Of ◽  
Acyl Derivatives

Studies on the Asymmetric Oxidation of Ester Derivatives of 1,3-Dithiane-2-carboxylates. Asymmetric Synthesis oftrans-1,3-Dithiane 1,3-Dioxide

1998 ◽  
Vol 63 (21) ◽  
pp. 7306-7310 ◽  
Author(s):  
Varinder K. Aggarwal ◽  
Blanca N. Esquivel-Zamora ◽  
Graham R. Evans ◽  
Elfyn Jones
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Oxidation ◽  
Derivatives Of
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