Ruthenium complexes as inhibitors of human islet amyloid polypeptide aggregation, an effect that prevents beta cell apoptosis

RSC Advances ◽  
2015 ◽  
Vol 5 (23) ◽  
pp. 17405-17412 ◽  
Author(s):  
Lijuan Ma ◽  
Yuanting Fu ◽  
Lianling Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Apoptosis ◽  
Cell Damage ◽  
Islet Amyloid Polypeptide ◽  
Ruthenium Complexes ◽  
Human Islet ◽  
Ros Generation ◽  
Beta Cell Apoptosis ◽  
Islet Amyloid ◽  
Application Potential

Herein we show that ruthenium complexes could inhibit fibrosis of hIAPP and protect the hIAPP-induced cell damage by suppressing ROS generation, indicating the application potential of the complexes in treatment of T2DM by targeting hIAPP.

scholarly journals Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

Diabetologia ◽  
2009 ◽  
Vol 52 (4) ◽  
pp. 626-635 ◽  
Author(s):  
S. Zraika ◽  
R. L. Hull ◽  
J. Udayasankar ◽  
K. Aston-Mourney ◽  
S. L. Subramanian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis ◽  
Amyloid Formation ◽  
Islet Amyloid

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2126-P
Author(s):  
ANDREW T. TEMPLIN ◽  
MAHNAZ MELLATI ◽  
DANIEL ZEMAN-MEIER ◽  
MEGHAN F. HOGAN ◽  
NATHALIE ESSER ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Amyloid Polypeptide ◽  
Amyloid Deposition ◽  
Human Islet ◽  
Cell Secretion ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide ◽  
Beta Cell Secretion

Ruthenium complexes as novel inhibitors of human islet amyloid polypeptide fibril formation

Metallomics ◽  
2013 ◽  
Vol 5 (12) ◽  
pp. 1599 ◽  
Author(s):  
Lei He ◽  
Xuesong Wang ◽  
Cong Zhao ◽  
Hongfei Wang ◽  
Weihong Du
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Ruthenium Complexes ◽  
Fibril Formation ◽  
Human Islet ◽  
Islet Amyloid ◽  
Human Islet Amyloid Polypeptide

scholarly journals Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

2010 ◽  
Vol 165 (2-3) ◽  
pp. 158-162 ◽  
Author(s):  
Robert A. Ritzel ◽  
Sajith Jayasinghe ◽  
John B. Hansen ◽  
Jeppe Sturis ◽  
Ralf Langen ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Katp Channel ◽  
Islet Amyloid Polypeptide ◽  
Human Islets ◽  
Human Islet ◽  
Islet Amyloid ◽  
Channel Activation ◽  
Human Islet Amyloid Polypeptide
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