Phase-induced porous composite microspheres sintered scaffold with protein–mineral interface for bone tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22005-22014 ◽  
Author(s):  
Janani Radhakrishnan ◽  
Gnana Santi Phani Deepika Gandham ◽  
Swaminathan Sethuraman ◽  
Anuradha Subramanian
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Composite ◽  
Multi Scale ◽  
Composite Microspheres ◽  
Biomimetic Scaffolds

Phase induced porous composite microspheres were solvent/non-solvent sintered to construct 3D multi-scale porous biomimetic scaffolds with and without protein for bone tissue engineering.

Mineralized Nanofibers for Bone Tissue Engineering

2018 ◽  
pp. 461-475 ◽  
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

Review of zirconia-based biomimetic scaffolds for bone tissue engineering

2021 ◽  
Vol 56 (14) ◽  
pp. 8309-8333
Author(s):  
Wenxian Weng ◽  
Weiwei Wu ◽  
Mengdie Hou ◽  
Taotao Liu ◽  
Tianlin Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomimetic Scaffolds

A novel route in bone tissue engineering: Magnetic biomimetic scaffolds

2010 ◽  
Vol 6 (3) ◽  
pp. 786-796 ◽  
Author(s):  
N. Bock ◽  
A. Riminucci ◽  
C. Dionigi ◽  
A. Russo ◽  
A. Tampieri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomimetic Scaffolds
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