cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (29) ◽  
pp. 22957-22964 ◽  
Author(s):  
Xingang Guan ◽  
Xiuli Hu ◽  
Zhihong Li ◽  
Hong Zhang ◽  
Zhigang Xie
Keyword(s):  
Controlled Release ◽  
Tumor Cells ◽  
Cellular Uptake ◽  
Polymeric Micelle ◽  
Doxorubicin Delivery ◽  
High Cytotoxicity

A biodegradable polymeric micelle with cRGD targeting and charge-conversional moiety could enhance the cellular uptake of pharmaceuticals and result in high cytotoxicity to tumor cells.

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

2008 ◽  
Vol 1780 (4) ◽  
pp. 673-679 ◽  
Author(s):  
A. Kunwar ◽  
A. Barik ◽  
B. Mishra ◽  
K. Rathinasamy ◽  
R. Pandey ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Uptake

Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system

2011 ◽  
Vol 149 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Yiguang Wang ◽  
Tingyuan Yang ◽  
Xun Wang ◽  
Wenbing Dai ◽  
Jiancheng Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Tumor Vasculature ◽  
Polymeric Micelle ◽  
Micelle System

Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes

2019 ◽  
Vol 6 (2) ◽  
pp. 376-390 ◽  
Author(s):  
João Honorato ◽  
Legna Colina-Vegas ◽  
Rodrigo S. Correa ◽  
Adriana P. M. Guedes ◽  
Marcelo Miyata ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Uptake ◽  
Ruthenium Complexes ◽  
Carboxyl Group ◽  
Carboxylic Group ◽  
Complex Interactions ◽  
Acid Ligand ◽  
Free Carboxyl

The esterification of the free carboxyl group in ruthenium complexes improves the complex interactions with biomolecules, lipophilicity, and cellular uptake, making them more selective against tumor cells than cisplatin.

scholarly journals Tumor-Homing pH-Sensitive Extracellular Vesicles for Targeting Heterogeneous Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 372 ◽  
Author(s):  
Jaeduk Park ◽  
Hyuk Lee ◽  
Yu Seok Youn ◽  
Kyung Taek Oh ◽  
Eun Seong Lee
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Extracellular Vesicles ◽  
Cellular Uptake ◽  
Deoxycholic Acid ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Cell Cytotoxicity ◽  
Tumor Treatment ◽  
Tumor Homing

In this study, we fabricated tumor-homing pH-sensitive extracellular vesicles for efficient tumor treatment. These vesicles were prepared using extracellular vesicles (EVs; BTEVs extracted from BT-474 tumor cells or SKEVs extracted from SK-N-MC tumor cells), hyaluronic acid grafted with 3-(diethylamino)propylamine (HDEA), and doxorubicin (DOX, as a model antitumor drug). Consequently, HDEA/DOX anchored EVs (HDEA@EVs) can interact with origin tumor cells owing to EVs’ homing ability to origin cells. Therefore, EV blends of HDEA@BTEVs and HDEA@SKEVs demonstrate highly increased cellular uptake in both BT-474 and SK-N-MC cells: HDEA@BTEVs for BT-474 tumor cells and HDEA@SKEVs for SK-N-MC tumor cells. Furthermore, the hydrophobic HDEA present in HDEA@EVs at pH 7.4 can switch to hydrophilic HDEA at pH 6.5 as a result of acidic pH-induced protonation of 3-(diethylamino)propylamine (DEAP) moieties, resulting in an acidic pH-activated EVs’ disruption, accelerated release of encapsulated DOX molecules, and highly increased cell cytotoxicity. However, EV blends containing pH-insensitive HA grafted with deoxycholic acid (HDOC) (HDOC@BTEVs and HDOC@SKEVs) showed less cell cytotoxicity for both BT-474 and SK-N-MC tumor cells, because they did not act on EVs’ disruption and the resulting DOX release. Consequently, the use of these tumor-homing pH-sensitive EV blends may result in effective targeted therapies for various tumor cells.

Acetate ions enhance load and stability of doxorubicin onto PEGylated nanodiamond for selective tumor intracellular controlled release and therapy

2016 ◽  
Vol 8 (9) ◽  
pp. 956-967 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Wenjing Zhao ◽  
Yingqi Li ◽  
Binsheng Yang
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Cells ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Normal Tissue ◽  
Delivery Device ◽  
Drug Delivery Device

A successful drug delivery device for cancer chemotherapy should ideally be able to load drugs highly, bring the drug preferentially into tumor cells and reduce its distribution in normal tissue to enhance therapeutic efficacy.

Biodegradable polymeric micelle-encapsulated doxorubicin suppresses tumor metastasis by killing circulating tumor cells

Nanoscale ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 5270-5280 ◽  
Author(s):  
Senyi Deng ◽  
Qinjie Wu ◽  
Yuwei Zhao ◽  
Xin Zheng ◽  
Ni Wu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mouse Models ◽  
Tumor Metastasis ◽  
Polymeric Micelle ◽  
Potential Applications

Doxorubicin (Dox) micelles showed improved anti-metastasis activity by killing circulating tumor cells (CTCs) in zebrafish and mouse models, which may have potential applications in cancer therapy.

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