Novel magnetic nanocomposite injectables: calcium phosphate cements impregnated with ultrafine magnetic nanoparticles for bone regeneration

RSC Advances ◽  
2015 ◽  
Vol 5 (18) ◽  
pp. 13411-13419 ◽  
Author(s):  
Roman A. Perez ◽  
Kapil D. Patel ◽  
Hae-Won Kim
Keyword(s):  
Magnetic Nanoparticles ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Magnetite Nanoparticles ◽  
Biological Properties ◽  
Magnetic Nanocomposite ◽  
Calcium Phosphate Cements ◽  
Physico Chemical

Novel magnetic nanocomposite injectables made of calcium phosphate cements and magnetite nanoparticles demonstrated excellent physico-chemical and biological properties effective for bone regeneration.

scholarly journals Physico-chemical–mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates

Biomaterials ◽  
2007 ◽  
Vol 28 (6) ◽  
pp. 956-965 ◽  
Author(s):  
Marion Julien ◽  
Ibrahim Khairoun ◽  
Racquel Z. LeGeros ◽  
Severine Delplace ◽  
Paul Pilet ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Biological Properties ◽  
Calcium Phosphate Cements ◽  
Physico Chemical

scholarly journals Calcium phosphate cements for bone engineering and their biological properties

Bone Research ◽  
2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Hockin HK Xu ◽  
Ping Wang ◽  
Lin Wang ◽  
Chongyun Bao ◽  
Qianming Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biological Properties ◽  
Bone Engineering ◽  
Calcium Phosphate Cements

scholarly journals Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres

2020 ◽  
Vol 21 (11) ◽  
pp. 3745
Author(s):  
Michiyo Honda ◽  
Yusuke Kawanobe ◽  
Kohei Nagata ◽  
Ken Ishii ◽  
Morio Matsumoto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bacterial Adhesion ◽  
Inflammatory Responses ◽  
Spray Pyrolysis Technique ◽  
Biological Properties ◽  
Histological Evaluation ◽  
Bone Apposition ◽  
Calcium Phosphate Cements

Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Silver-containing tricalcium phosphate (Ag-TCP) microspheres consisting of α/β-TCP phases were synthesized by an ultrasonic spray-pyrolysis technique. The powders prepared were mixed with the setting liquid to fabricate the CPCs. The resulting cements consisting of β-TCP and hydroxyapatite had a porous structure and wash-out resistance. Additionally, silver and calcium ions could be released into the culture medium from Ag-TCP cements for a long time accompanied by the dissolution of TCP. These data showed the bioresorbability of the Ag-TCP cement. In vitro antibacterial evaluation demonstrated that both released and immobilized silver suppressed the growth of bacteria and prevented bacterial adhesion to the surface of CPCs. Furthermore, histological evaluation by implantation of Ag-TCP cements into rabbit tibiae exhibited abundant bone apposition on the cement without inflammatory responses. These results showed that Ag-TCP cement has a good antibacterial property and good biocompatibility. The present Ag-TCP cements are promising for bone tissue engineering and may be used as antibacterial biomaterials.

Foamed β-Tricalcium Phosphate Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 323-326 ◽  
Author(s):  
Edgar Benjamin Montufar ◽  
C. Gil ◽  
Tania Traykova ◽  
M.P. Ginebra ◽  
Josep A. Planell
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Initial Material ◽  
Sintering Process ◽  
Bioactive Material ◽  
Bioactive Scaffolds ◽  
Calcium Phosphate Cements ◽  
Beta Tricalcium Phosphate ◽  
Nanometric Range

The design and processing of 3D macroporous bioactive scaffolds is one of the milestones for the progress of bone tissue engineering and bone regeneration. Calcium phosphate based ceramics are among the most suitable materials, due to their similarity to the bone mineral. Specifically, beta-tricalcium phosphate (β-TCP) is known to be a resorbable and bioactive material, with well established applications as bone regeneration material. The aim of this work is to explore a new route to obtain β-TCP macroporous scaffolds starting from calcium phosphate cements. To this end foamed calcium phosphate cement, composed of alpha tricalcium phosphate as starting powder was used as initial material. The set foamed structures, made of calcium deficient hydroxyapatite (CDHA) were sintered to obtain the final β-TCP macroporous architecture. The interconnected macroporosity was maintained, whereas the porosity in the nanometric range was strongly reduced by the sintering process. The sintering produced also an increase in the mechanical properties of the scaffold.

Preparation of strontium-containing calcium phosphate cements for maxillofacial bone regeneration

2016 ◽  
Vol 32 ◽  
pp. e49 ◽  
Author(s):  
R. Masaeli ◽  
T.S. Jafarzadeh Kashi ◽  
W. Yao ◽  
K. Khoshroo ◽  
M. Tahriri ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Cements

scholarly journals Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

2021 ◽  
Vol 2 ◽  
Author(s):  
Rashed A. Alsahafi ◽  
Heba Ahmed Mitwalli ◽  
Abdulrahman A. Balhaddad ◽  
Michael D. Weir ◽  
Hockin H. K. Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Current Status ◽  
Craniofacial Bone ◽  
Calcium Phosphate Cements ◽  
And Performance

The management and treatment of dental and craniofacial injuries have continued to evolve throughout the last several decades. Limitations with autograft, allograft, and synthetics created the need for more advanced approaches in tissue engineering. Calcium phosphate cements (CPC) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. This review focuses on the up-to-date performance of calcium phosphate cement (CPC) scaffolds and upcoming promising dental and craniofacial bone regeneration strategies. First, we summarized the barriers encountered in CPC scaffold development. Second, we compiled the most up to date in vitro and in vivo literature. Then, we conducted a systematic search of scientific articles in MEDLINE and EMBASE to screen the related studies. Lastly, we revealed the current developments to effectively design CPC scaffolds and track the enhanced viability and therapeutic efficacy to overcome the current limitations and upcoming perspectives. Finally, we presented a timely and opportune review article focusing on the significant potential of CPC scaffolds for dental and craniofacial bone regeneration, which will be discussed thoroughly. CPC offers multiple capabilities that may be considered toward the oral defects, expecting a future outlook in nanotechnology design and performance.

scholarly journals Implications of protein corona on physico-chemical and biological properties of magnetic nanoparticles

Biomaterials ◽  
2015 ◽  
Vol 46 ◽  
pp. 1-12 ◽  
Author(s):  
Murali M. Yallapu ◽  
Neeraj Chauhan ◽  
Shadi F. Othman ◽  
Vahid Khalilzad-Sharghi ◽  
Mara C. Ebeling ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Protein Corona ◽  
Biological Properties ◽  
Physico Chemical

Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

2010 ◽  
Vol 21 (10) ◽  
pp. 2853-2859 ◽  
Author(s):  
Gerlind Schneider ◽  
Karin Blechschmidt ◽  
Dirk Linde ◽  
Peter Litschko ◽  
Thomas Körbs ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Glass Ceramic ◽  
Defect Model ◽  
Calcium Phosphate Cements ◽  
Cranial Defect ◽  
Ceramic Implants
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