Synthesis and encapsulation of an amphiphilic thermoresponsive star polymer with β-cyclodextrin and hyperbranched poly(oligo(ethylene glycol)methacrylate) as building blocks

RSC Advances ◽  
2014 ◽  
Vol 4 (97) ◽  
pp. 54268-54281 ◽  
Author(s):  
Yinwen Li ◽  
Huilong Guo ◽  
Jian Zheng ◽  
Jianqun Gan ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Building Blocks ◽  
Star Polymer ◽  
Thermally Induced ◽  
Glycol Methacrylate ◽  
Hyperbranched Poly

Schematic illustrations of the thermally-induced self-assembly and possible encapsulation behaviors with single or multi-guests for PE-CD–POEGMAS.

scholarly journals Well-Defined Thermo-Responsive Copolymers Based on Oligo(Ethylene Glycol) Methacrylate and Pentafluorostyrene for the Removal of Organic Dyes from Water

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1779
Author(s):  
Federica Zuppardi ◽  
Mario Malinconico ◽  
Franck D’Agosto ◽  
Giovanna Gomez D’Ayala ◽  
Pierfrancesco Cerruti
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Organic Contaminants ◽  
Organic Dyes ◽  
Raft Polymerization ◽  
Nile Red ◽  
Solution Temperature ◽  
Thermally Induced ◽  
Glycol Methacrylate

Thermo-responsive copolymers based on oligo(ethylene glycol) methacrylate (OEGMA, Mn = 300 g/mol) and pentafluorostyrene (PFS), coded PFG, were synthesized by RAFT polymerization, using a trithiocarbonate (CTTPC) as controlling agent. Different molar masses were targeted and dispersities lower than 1.51 were obtained. The thermally triggered self-assembly of the resulting PFG copolymers in water was investigated by dynamic light scattering (DLS). The lower critical solution temperature (LCST) slightly increased with the molecular weight in the 26–30 °C temperature range, whereas the sizes of the intermicellar aggregates formed upon self-assembly tended to decrease with increasing molecular weights (ranging from 1415 to 572 nm). The resulting thermally-induced polymer aggregates were then used to encapsulate and remove organic contaminants from water. Nile Red (NR) and Thiazole yellow G (TYG) were employed as hydrophobic and hydrophilic model contaminants, respectively. Experimental results evidenced that higher molecular weight copolymers removed up to 90% of NR from aqueous solution, corresponding to about 10 mg of dye per g of copolymer, regardless of NR concentration. The removal of TYG was lower with respect to NR, decreasing from about 40% to around 20% with TYG concentration. Finally, the copolymers were shown to be potentially recycled and reused in the treatment of contaminated water.

Pseudo-graft polymer based on adamantyl-terminated poly(oligo(ethylene glycol) methacrylate) and homopolymer with cyclodextrin as pendant: its thermoresponsivity through polymeric self-assembly and host–guest inclusion complexation

RSC Advances ◽  
2014 ◽  
Vol 4 (34) ◽  
pp. 17768-17779 ◽  
Author(s):  
Yinwen Li ◽  
Huilong Guo ◽  
Yunfei Zhang ◽  
Jian Zheng ◽  
Jianqun Gan ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Inclusion Complexation ◽  
Graft Polymer ◽  
Glycol Methacrylate

Thermoresponsivity and self-assembly of a pseudo-graft polymer based on Ad-terminated poly(oligo(ethylene glycol) methacrylate) and homopolymer with CD pendants.

Fluorinated oligo(ethylene glycol) methacrylate-based copolymers: Tuning of self assembly properties and relationship with rheological behavior

Polymer ◽  
2017 ◽  
Vol 112 ◽  
pp. 169-179 ◽  
Author(s):  
Federica Zuppardi ◽  
Francesco Raffaele Chiacchio ◽  
Roberta Sammarco ◽  
Mario Malinconico ◽  
Giovanna Gomez d'Ayala ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Rheological Behavior ◽  
Self Assembly ◽  
Glycol Methacrylate

Synthesis and thermo-responsive self-assembly behavior of amphiphilic copolymer β-CD–(PCL–P(MEO2MA-co-PEGMA))21 for the controlled intracellular delivery of doxorubicin

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 50993-51004 ◽  
Author(s):  
Beibei Lu ◽  
Lei Li ◽  
Lulu Wei ◽  
Xuhong Guo ◽  
Jun Hou ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Intracellular Delivery ◽  
Amphiphilic Copolymer ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Ethyl Methacrylate ◽  
Assembly Behavior ◽  
Poly Ethylene

Well-defined amphiphilic β-cyclodextrin star-shaped copolymers with poly(ε-caprolactone)–poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-poly(ethylene glycol)methacrylate) (β-CD–(PCL–P(MEO2MA-co-PEGMA))21 were synthesized via (ROP) and (ATRP).

scholarly journals Synthesis, Characterization and Cytotoxicity of Novel Thermoresponsive Star Copolymers of N,N′-Dimethylaminoethyl Methacrylate and Hydroxyl-Bearing Oligo(Ethylene Glycol) Methacrylate

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1255 ◽  
Author(s):  
Barbara Mendrek ◽  
Agnieszka Fus ◽  
Katarzyna Klarzyńska ◽  
Aleksander Sieroń ◽  
Mario Smet ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Point Temperature ◽  
Glycol Methacrylate ◽  
Dimethylaminoethyl Methacrylate ◽  
Star Copolymers ◽  
Hyperbranched Poly ◽  
Cloud Point Temperature ◽  
Oh Content

Novel, nontoxic star copolymers of N,N-dimethylaminoethyl methacrylate (DMAEMA) and hydroxyl-bearing oligo(ethylene glycol) methacrylate (OEGMA-OH) were synthesized via atom transfer radical polymerization (ATRP) using hyperbranched poly(arylene oxindole) as the macroinitiator. Stars with molar masses from 100,000 g/mol to 257,000 g/mol and with various amounts of OEGMA-OH in the arms were prepared. As these polymers can find applications, e.g., as carriers of nucleic acids, drugs or antibacterial or antifouling agents, in this work, much attention has been devoted to exploring their solution behavior and their stimuli-responsive properties. The behavior of the stars was studied in aqueous solutions under various pH and temperature conditions, as well as in PBS buffer, in Dulbecco’s modified Eagle’s medium (DMEM) and in organic solvents for comparison. The results indicated that increasing the content of hydrophilic OEGMA-OH units in the arms up to 10 mol% increased the cloud point temperature. For the stars with an OEGMA-OH content of 10 mol%, the thermo- and pH-responsivity was switched off. Since cytotoxicity experiments have shown that the obtained stars are less toxic than homopolymer DMAEMA stars, the presented studies confirmed that the prepared polymers are great candidates for the design of various nanosystems for biomedical applications.

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