Large-scale production of spherical Y2O3:Eu3+ phosphor powders with narrow size distribution using a two-step spray drying method

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 62965-62970 ◽  
Author(s):  
Jung Sang Cho ◽  
Kyeong Youl Jung ◽  
Mun Young Son ◽  
Yun Chan Kang
Keyword(s):  
Size Distribution ◽  
Spray Drying ◽  
Mass Production ◽  
Large Scale ◽  
Scale Production ◽  
Narrow Size Distribution ◽  
Drying Method ◽  
Large Scale Production

Dense spherical Y2O3:Eu3+ phosphor particles with a narrow size distribution were successfully prepared by using a two-step spray drying method. This method is easily scalable and can therefore be applied to the mass production of phosphor particles with high photoluminescence.

scholarly journals A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Anirban Nandi ◽  
Sharadwata Pan ◽  
Ravichandra Potumarthi ◽  
Michael K. Danquah ◽  
Indira P. Sarethy
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Six Sigma ◽  
Mass Production ◽  
Large Scale ◽  
Penicillin G ◽  
Scale Production ◽  
Large Scale Production ◽  
Subsequent Conversion ◽  
Six Sigma Methodology

Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.

The Wexler Bend Pilot Plant

2018 ◽  
Author(s):  
Colin F. Baxter
Keyword(s):  
United States ◽  
World War Ii ◽  
Mass Production ◽  
Pilot Plant ◽  
Large Scale ◽  
The United States ◽  
Scale Production ◽  
World War ◽  
Large Scale Production ◽  
Scientific Achievements

One of the epic industrial and scientific achievements of the United States during World War II was accomplished at the Wexler Bend Pilot Plant, Kingsport, Tennessee, where fifty hand-picked (their finances were investigated, and all the operators were married with at least one child) Tennessee Eastman employees, working at a phenomenal pace, developed a process for large-scale production of the world’s most powerful explosive, RDX. The success at Wexler Bend opened the door to the next phase: the mass production of RDX.

scholarly journals THE ORGANISATION OF DRILL PRODUCTION AT A NEOLITHIC LITHIC WORKSHOP SITE OF BAI BEN, CAT BA ISLAND, VIETNAM

2014 ◽  
Vol 33 ◽  
pp. 24
Author(s):  
Dong Truong Nguyen ◽  
Chris Clarkson
Keyword(s):  
Mass Production ◽  
Large Scale ◽  
Raw Materials ◽  
Morphological Changes ◽  
Scale Production ◽  
Late Neolithic ◽  
Diverse Range ◽  
Large Scale Production ◽  
Drill Point ◽  
Trade And Exchange

We investigate stone drill point production, use, maintenance, and discard from a technological perspective at the Late Neolithic workshop of Bai Ben on Cat Ba Island, Northeastern Vietnam. Bai Ben contains over 18,000 retouched chert flakes classified as drill points and dating to c.3000BP. Large scale production of drills most likely took place for reasons of mass production of drilled organic and inorganic objects. Few of such drilled objects are found at the site, perhaps due to poor organic preservation or removal of finished objects for trade and exchange. An analysis of attribute on drills and cores examines the time-ordering of dimensional and morphological changes as reduction continued at the site. The research finds that drills were produced from a diverse range of nodules sizes, blanks, core technologies and raw materials, but similar blanks were selected to produce very similar drill point forms.

scholarly journals Millimeter-Size Spherical Polyurea Aerogel Beads with Narrow Size Distribution

Gels ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 66 ◽  
Author(s):  
Despoina Chriti ◽  
Grigorios Raptopoulos ◽  
Maria Papastergiou ◽  
Patrina Paraskevopoulou
Keyword(s):  
Size Distribution ◽  
Large Scale ◽  
High Surface ◽  
High Surface Area ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Scale Production ◽  
High Porosity ◽  
Narrow Size Distribution ◽  
Angle Spinning

We report the room temperature synthesis of spherical millimeter-size polyurea (PUA) aerogel beads. Wet-gels of said beads were obtained by dripping a propylene carbonate solution of an aliphatic triisocyanate based on isocyanurate nodes into a mixture of ethylenediamine and heavy mineral oil. Drying the resulting wet spherical gels with supercritical fluid (SCF) CO2 afforded spherical aerogel beads with a mean diameter of 2.7 mm, and a narrow size distribution (full width at half maximum: 0.4 mm). Spherical PUA aerogel beads had low density (0.166 ± 0.001 g cm–3), high porosity (87% v/v) and high surface area (197 m2 g–1). IR, 1H magic angle spinning (MAS) and 13C cross-polarization magic angle spinning (CPMAS) NMR showed the characteristic peaks of urea and the isocyanurate ring. Scanning electron microscopy (SEM) showed the presence of a thin, yet porous skin on the surface of the beads with a different (denser) morphology than their interior. The synthetic method shown here is simple, cost-efficient and suitable for large-scale production of PUA aerogel beads.

scholarly journals DoE Analysis of Approaches for Hydrogel Microbeads’ Preparation by Millifluidic Methods

Micromachines ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1007
Author(s):  
Anna Nastruzzi ◽  
Gabriele Pitingolo ◽  
Giovanni Luca ◽  
Claudio Nastruzzi
Keyword(s):  
Mass Production ◽  
Large Scale ◽  
Single Cells ◽  
Great Promise ◽  
Scale Production ◽  
Large Scale Production ◽  
Different Types ◽  
Cell Transplants

Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterization of highly controlled and reproducible microbeads made by different types of hydrogel using millifluidic approaches. The optimization of the process was made by a design of experiments (DoE) approach. The microbeads’ large-scale production can be potentially used for single cells or clusters encapsulation.

scholarly journals Large-scale production of recombinant miraculin protein in transgenic carrot callus supension cultures using air-lift bioreactors

2020 ◽  
Author(s):  
Yun-Ji Park ◽  
Jong-Eun Han ◽  
Hyoshin Lee ◽  
Yu-Jin Jung ◽  
Hoskatte Niranjana Murthy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Mass Production ◽  
Large Scale ◽  
Sweet Taste ◽  
Callus Cultures ◽  
Scale Production ◽  
Daucus Carota L ◽  
Large Scale Production ◽  
Air Lift

Abstract Miraculin, derived from the miracle fruit ( Synsepalum dulcificum ), is a taste-regulating protein that interacts with human sweet-taste receptors and transforms sourness into sweet taste. Since miracle fruit is cultivated in West Africa, mass production of miraculin is limited by regional and seasonal constraints. Here, we investigated mass production of recombinant miraculin in carrot ( Daucus carota L.) callus cultures using an air-lift bioreactor. To increase miraculin expression, the oxidative stress-inducible SWAP2 promoter was used to drive the expression of miraculin gene under various stress treatments. An 8 h treatment of hydrogen peroxide (H 2 O 2 ) and salt (NaCl) increased the expression of miraculin gene by 5-fold compared with the untreated control. On the other hand, abscisic acid, salicylic acid, and methyl jasmonate treatments showed no significant impact on miraculin gene expression compared with the control. This shows that since H 2 O 2 and NaCl treatments induce oxidative stress, they activate the SWPA2 promoter and consequently up-regulate miraculin gene expression. Thus, the results of this study provide a foundation for industrial-scale production of recombinant miraculin protein using transgenic carrot cells as a heterologous host.

scholarly journals Large-scale production of recombinant miraculin protein in transgenic carrot callus supension cultures using air-lift bioreactors

2020 ◽  
Author(s):  
Yun-Ji Park ◽  
Jong-Eun Han ◽  
Hyoshin Lee ◽  
Yu-Jin Jung ◽  
Hoskatte Niranjana Murthy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Mass Production ◽  
Large Scale ◽  
Sweet Taste ◽  
Callus Cultures ◽  
Scale Production ◽  
Daucus Carota L ◽  
Large Scale Production ◽  
Air Lift

Abstract Miraculin, derived from the miracle fruit ( Synsepalum dulcificum ), is a taste-regulating protein that interacts with human sweet-taste receptors and transforms sourness into sweet taste. Since miracle fruit is cultivated in West Africa, mass production of miraculin is limited by regional and seasonal constraints. Here, we investigated mass production of recombinant miraculin in carrot ( Daucus carota L.) callus cultures using an air-lift bioreactor. To increase miraculin expression, the oxidative stress-inducible SWAP2 promoter was used to drive the expression of miraculin gene under various stress treatments. An 8 h treatment of hydrogen peroxide (H 2 O 2 ) and salt (NaCl) increased the expression of miraculin gene by 5-fold compared with the untreated control. On the other hand, abscisic acid, salicylic acid, and methyl jasmonate treatments showed no significant impact on miraculin gene expression compared with the control. This shows that since H 2 O 2 and NaCl treatments induce oxidative stress, they activate the SWPA2 promoter and consequently up-regulate miraculin gene expression. Thus, the results of this study provide a foundation for industrial-scale production of recombinant miraculin protein using transgenic carrot cells as a heterologous host.

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