Ag-grafted covalent imine network material for one-pot three-component coupling and hydration of nitriles to amides in aqueous medium

RSC Advances ◽  
2014 ◽  
Vol 4 (88) ◽  
pp. 47593-47604 ◽  
Author(s):  
Noor Salam ◽  
Sudipta K. Kundu ◽  
Rostam Ali Molla ◽  
Paramita Mondal ◽  
Asim Bhaumik ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Coupling Reactions ◽  
One Pot ◽  
Chemical Route ◽  
Simple Chemical ◽  
Three Component Coupling

Silver grafted porous covalent imine network material (Ag-CIN-1) has been designed via a simple chemical route and it has been successfully employed as catalyst for the hydration of nitriles to amides and the A3 coupling reactions of an alkyne, an amine and an aldehyde in water.

Three-component coupling reactions in ionic liquids: One-pot synthesis of isoxazolidines

2007 ◽  
Vol 270 (1-2) ◽  
pp. 160-163 ◽  
Author(s):  
J.S. Yadav ◽  
B.V.S. Reddy ◽  
P. Sreedhar ◽  
Ch.V.S.R. Murthy ◽  
G. Mahesh ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Coupling Reactions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Coupling

Catalysis by metal–organic frameworks: proline and gold functionalized MOFs for the aldol and three-component coupling reactions

RSC Advances ◽  
2014 ◽  
Vol 4 (25) ◽  
pp. 13093-13107 ◽  
Author(s):  
Liu Lili ◽  
Zhang Xin ◽  
Rang Shumin ◽  
Yang Ying ◽  
Dai Xiaoping ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Metal Organic Frameworks ◽  
Coupling Reaction ◽  
Coupling Reactions ◽  
One Pot ◽  
Postsynthetic Modification ◽  
Highly Efficient ◽  
Synthetic Strategy ◽  
Metal Organic ◽  
Three Component Coupling

Homochiral MOFs were engineered using postsynthetic modification and a one-pot synthetic strategy. l-Proline functionalized IRMOF-3 show high ee for aldol reaction. Gold functionalized CUP-1 catalysts are highly efficient for the A3 coupling reaction.

A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions

2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Cross Coupling ◽  
Modular Approach ◽  
Coupling Reactions ◽  
One Pot ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Chemistry Research

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>

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