Driving an equilibrium acetalization to completion in the presence of water

RSC Advances ◽  
2014 ◽  
Vol 4 (69) ◽  
pp. 36864-36867 ◽  
Author(s):  
Maki Minakawa ◽  
Yoichi M. A. Yamada ◽  
Yasuhiro Uozumi
Keyword(s):  
Laminar Flow ◽  
Residence Times ◽  
Microflow Reactor ◽  
Polymeric Acid

A polymeric acid membrane was generated at the laminar flow interface in a microflow reactor. The polymeric acid membrane-installed microflow devices achieved condensation of a variety of carbonyl substrates with diols to give the corresponding acetals in yields of up to 97% for residence times of 19 to 38 s.

Rate of advancement of reactions in turbulent flows

1964 ◽  
Vol 17 (8) ◽  
pp. 821 ◽  
Author(s):  
RCL Bosworth ◽  
CM Groden
Keyword(s):  
Laminar Flow ◽  
Turbulent Flow ◽  
Turbulent Flows ◽  
Residence Time ◽  
Time Distribution ◽  
Residence Time Distribution ◽  
Residence Times ◽  
Cylindrical Reactor ◽  
The Times ◽  
Very High

When a reacting substance or mixture is caused to flow in a cylindrical reactor, all portions of the stream will not flow at the same rate and will exhibit different residence times and, accordingly, are subject to different extents of degrees of reaction. The average degrees of reaction following the residence time distribution proper to laminar flow are given in the earlier publication1 and this paper extends the treatment to that of turbulent flow. In the earlier treatment of laminar flow the ratio of average extent of reaction with non-interacting streams to that of complete intermingling, or the C/Cm, is plotted against the ratio of the times of flow with those of reaction (S). The C/Cm versus S curves are all above unity and increase with increasing S, with the exception of very high orders of chemical reaction for which values of C/Cm are all unity. In the case of turbulent flow the values of C/Cm are more nearly unity at all values of S.

A Novel Electrosynthetic System for Anodic Substitution Reactions by Using Parallel Laminar Flow in a Microflow Reactor

2008 ◽  
Vol 14 (33) ◽  
pp. 10382-10387 ◽  
Author(s):  
Daisuke Horii ◽  
Fumihiro Amemiya ◽  
Toshio Fuchigami ◽  
Mahito Atobe
Keyword(s):  
Laminar Flow ◽  
Substitution Reactions ◽  
Microflow Reactor

Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies

2006 ◽  
Vol 45 (03) ◽  
pp. 134-138 ◽  
Author(s):  
T. Kull ◽  
N. M. Blumstein ◽  
D. Bunjes ◽  
B. Neumaier ◽  
A. K. Buck ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bone Marrow ◽  
Gamma Camera ◽  
Absorbed Dose ◽  
Correlation Coefficients ◽  
Residence Times ◽  
Reliable Prediction ◽  
Red Bone Marrow ◽  
Antibody Preparation ◽  
Simplified Method

SummaryAim: For the therapeutic application of radiopharmaceuticals the activity is determined on an individual basis. Here we investigated the accuracy for a simplified assessment of the residence times for a 188Re-labelled anti-CD66 monoclonal antibody. Patients, methods: For 49 patients with high risk leukaemia (24 men, 25 women, age: 44 ± 12 years) the residence times were determined for the injected 188Re-labelled anti-CD66 antibodies (1.3 ± 0.4 GBq, 5–7 GBq/mg protein, >95% 188Re bound to the antibody) based on 5 measurements (1.5, 3, 20, 26, and 44 h p.i.) using planar conjugate view gamma camera images (complete method). In a simplified method the residence times were calculated based on a single measurement 3 h p.i. Results: The residence times for kidneys, liver, red bone marrow, spleen and remainder of body for the complete method were 0.4 ± 0.2 h, 1.9 ± 0.8 h, 7.8 ± 2.1 h, 0.6 ± 0.3 h and 8.6 ± 2.1 h, respectively. For all organs a linear correlation exists between the residence times of the complete method and the simplified method with the slopes (correlation coefficients R > 0.89) of 0.89, 0.99, 1.23, 1.13 and 1.09 for kidneys, liver, red bone marrow, spleen and remainder of body, respectively. Conclusion: The proposed approach allows reliable prediction of biokinetics of 188Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.

HYDRODYNAMICALLY DEVELOPED LAMINAR FLOW OF NON-NEWTONIAN FLUIDS INSIDE DOUBLE-SINE DUCTS

2001 ◽  
Vol 3 (2-3) ◽  
pp. 16 ◽  
Author(s):  
C. L. Chaves ◽  
Joao N. N. Quaresma ◽  
E. N. Macedo ◽  
L. M. Pereira ◽  
J. A. Lima
Keyword(s):  
Laminar Flow ◽  
Newtonian Fluids
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