One-pot NHC-assisted access to 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones

RSC Advances ◽  
2014 ◽  
Vol 4 (67) ◽  
pp. 35629-35634 ◽  
Author(s):  
Mingxing Liu ◽  
Jiarong Li ◽  
Shu Chen ◽  
Danfei Huang ◽  
Hongxin Chai ◽  
...  
Keyword(s):  
Reaction Synthesis ◽  
The Novel ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient ◽  
Novel Method

An efficient N-heterocyclic carbene-assisted one-pot reaction synthesis of 2,3-dihydropyrimido[4,5-d] pyrimidin-4(1H)-ones from 2-(ethoxymethylene)malononitrile, guanidines (or amidines) and ketones (or aldehyde) has been developed. The novel method provides a highly efficient synthesis of pyrimido[4,5-d]pyrimidinering from materials with no heterocyclic structures.

scholarly journals Highly Efficient Synthesis of (Phosphinodihydrooxazole)- (1,5-cyclooctadiene) Iridium Complexes

2009 ◽  
Vol 64 (10) ◽  
pp. 1147-1158 ◽  
Author(s):  
Volodymyr Semeniuchenko ◽  
Volodymyr Khilya ◽  
Ulrich Groth
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Iridium Complexes ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

A highly efficient one-pot procedure for the synthesis of complexes of the type [Ir(COD)(Phox)]X, where Phox is a (chiral) phosphinooxazoline ligand, X = PF6 or B[(3,5-(CF3)2C6H3)]4 (BARF), is developed. Former reported syntheses demanded the isolation of pure ligands by column chromatography, but the ligands tend to adsorb irreversibly on silica. Moreover, the chromatography has to be performed with careful exclusion of air. The present method avoids this difficulties. The yields of the syntheses are comparable with those starting from the pure ligands. The method is also suitable for the preparation of complexes of the type [Rh(COD)(Phox)]BARF and [Rh(Phox)2]BARF.

New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence

2020 ◽  
Vol 44 (9) ◽  
pp. 3632-3636
Author(s):  
Sandip Gangadhar Balwe ◽  
Yeon Tae Jeong
Keyword(s):  
Cascade Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

The first p-TSA·H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles has been discovered.

CuI/Et2NH-Catalyzed One-Pot Highly Efficient Synthesis of 1,4-Disubstituted 1,2,3-Triazoles in Green Solvent Glycerol

Synthesis ◽  
2018 ◽  
Vol 50 (11) ◽  
pp. 2191-2199 ◽  
Author(s):  
Yongde Zhao ◽  
Shengqiang Guo ◽  
Yang Zhou ◽  
Bencai Dai ◽  
Cuimeng Huo ◽  
...  
Keyword(s):  
Catalytic System ◽  
Sodium Azide ◽  
Room Temperature ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient ◽  
Three Component Reaction ◽  
Efficient Route ◽  
Terminal Acetylenes

A concise one-pot three-component reaction of organic halides­, terminal acetylenes, and sodium azide provided an efficient route for the synthesis of 1,2,3-triazoles. A variety of 1,2,3-triazoles were prepared in good to excellent yields with green solvent glycerol. This procedure used CuI and diethylamine, which are two easily available reagents as the new catalytic system at room temperature.

A one-pot synthesis of 2,2′-disubstituted diindolylmethanes (DIMs) via a sequential Sonogashira coupling and cycloisomerization/C3-functionalization of 2-iodoanilines

2017 ◽  
Vol 15 (33) ◽  
pp. 6997-7007 ◽  
Author(s):  
Anirban Kayet ◽  
Vinod K. Singh
Keyword(s):  
Sonogashira Coupling ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis

Pd(ii)–Ag(i) catalysed, highly efficient synthesis of diindolylmethanes under mild reaction conditions, with six new bonds being formed in a one-pot fashion, and the products being transformed into synthetically useful compounds.

Nanofibre Sepiolite Catalyzed Green and Rapid Synthesis of 2-Amino-4H-chromene Derivatives

2018 ◽  
Vol 71 (1) ◽  
pp. 32 ◽  
Author(s):  
Arezou Mohammadinezhad ◽  
Batool Akhlaghinia
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Simple Procedure ◽  
Reaction Times ◽  
Significant Decline ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
One Pot ◽  
Highly Efficient

Nanofibre sepiolite catalyzed the rapid, clean, and highly efficient synthesis of 2-amino-4H-chromene derivatives by a one-pot, three-component condensation of a series of aldehydes, various enolizable C–H bonds (such as dimedone, α-naphthol, resorcinol, and 4-hydroxy-2H-chromen-2-one), and malononitrile in a mixture of water/ethanol. The present method offers several advantages such as high to excellent yields, short reaction times, mild reaction conditions, simple procedure, use of inexpensive, non-toxic, and naturally available catalyst, easy isolation of the products, and no need for column chromatography. The catalyst could be easily separated from the reaction mixture and can be reused for many consecutive trials without a significant decline in its reactivity.

Highly efficient synthesis of tetrasubstituted 2,3-dihydropyrans by three-component ‘one-pot’ reaction

2016 ◽  
Vol 57 (20) ◽  
pp. 2171-2174 ◽  
Author(s):  
Chao Li ◽  
Liang-Zhen Cai ◽  
Xiao-Dong Liu ◽  
Shi-Zheng Zhu ◽  
Chun-Hui Xing ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

Synthesis of Bisflavanol-Type Natural Products and Their Analogues­ via Self-Coupling of C8-Methylol Catechin Derivatives

Synthesis ◽  
2019 ◽  
Vol 51 (16) ◽  
pp. 3127-3141
Author(s):  
Deng-Ming Huang ◽  
Hui-Jing Li ◽  
Yan Zhao ◽  
Yan-Chao Wu
Keyword(s):  
Natural Products ◽  
Coupling Mechanism ◽  
The Novel ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Acid Catalyzed

A highly efficient and regioselective self-coupling of C8-methylol catechin derivatives is developed for the synthesis of dimeric flavanol analogues under metal-free and mild conditions. Its applicability is showcased by the efficient synthesis of bisflavanol-type natural products bis-8,8′-catechinylmethane, bis-8,8′-epicatechinylmethane, talienbisflavan A, and oolonghomobisflavan A. The novel self-coupling mechanism sheds new light on the classical Friedel–Crafts alkylation mechanism in acid-catalyzed catechin–formaldehyde condensation.

Genesis of thiacalixarenes: a one-pot highly efficient synthesis of TC4A

2008 ◽  
Vol 49 (19) ◽  
pp. 3087-3091 ◽  
Author(s):  
Mitesh H. Patel ◽  
Vijay B. Patel ◽  
Pranav S. Shrivastav
Keyword(s):  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient
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