Synthesis, molecular modeling and biological evaluation of cinnamic acid derivatives with pyrazole moieties as novel anticancer agents

RSC Advances ◽  
2014 ◽  
Vol 4 (70) ◽  
pp. 37197-37207 ◽  
Author(s):  
Wei-Ming Zhang ◽  
Man Xing ◽  
Ting-Ting Zhao ◽  
Yu-Jia Ren ◽  
Xian-Hui Yang ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cinnamic Acid ◽  
Anticancer Agents ◽  
Inhibitory Activity ◽  
Anticancer Agent ◽  
Biological Evaluation ◽  
Cinnamic Acid Derivatives ◽  
Her 2

Compound 30e with potent EGFR and HER-2 inhibitory activity may be a potential anticancer agent.

Synthesis, molecular modeling, and biological evaluation of quinazoline derivatives containing the 1,3,4-oxadiazole scaffold as novel inhibitors of VEGFR2

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 19914-19923 ◽  
Author(s):  
Fang Qiao ◽  
Yong Yin ◽  
Yu-Ning Shen ◽  
She-Feng Wang ◽  
Shao Sha ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Inhibitory Activity ◽  
Anticancer Agent ◽  
Biological Evaluation ◽  
Quinazoline Derivatives ◽  
Inhibitory Activities ◽  
Potent Inhibitory Activity ◽  
Mcf 7

A series of 4-alkoxyquinazoline derivatives containing the 1,3,4-oxadiazole scaffold were designed and synthesized. Their inhibitory activities were tested against A549, MCF-7 and Hela. 4j showed the most potent inhibitory activity and may be a potential anticancer agent.

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents

2010 ◽  
Vol 18 (14) ◽  
pp. 4991-4996 ◽  
Author(s):  
Yong Qian ◽  
Hong-Jia Zhang ◽  
Hao Zhang ◽  
Chen Xu ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cinnamic Acid ◽  
Anticancer Agents ◽  
Biological Evaluation

scholarly journals Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Yang Ping Quan ◽  
Li Ping Cheng ◽  
Tian Chi Wang ◽  
Wan Pang ◽  
Fan Hong Wu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Hepg2 Cells ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Tubulin Inhibitors ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Compound 13a, more effective than CA-4 against HepG2 cells and tubulin, and the proposed binding mode for 13a.

Cinnamic Acid Derivatives as Anticancer Agents-A Review

2011 ◽  
Vol 18 (11) ◽  
pp. 1672-1703 ◽  
Author(s):  
P. De ◽  
M. Baltas ◽  
F. Bedos-Belval
Keyword(s):  
Cinnamic Acid ◽  
Anticancer Agents ◽  
Cinnamic Acid Derivatives

scholarly journals Germinated and Ungerminated Seeds Extract from TwoLupinusSpecies: Biological Compounds Characterization and In Vitro and In Vivo Evaluations

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Bogdan Andor ◽  
Corina Danciu ◽  
Ersilia Alexa ◽  
Istvan Zupko ◽  
Elena Hogea ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Therapeutic Potential ◽  
Lupinus Albus ◽  
Biological Evaluation ◽  
Lupinus Angustifolius ◽  
Cinnamic Acid Derivatives ◽  
Natural Agents ◽  
Germinated Seeds

In recent years, nutraceuticals attracted a great amount of attention in the biomedical research due to their significant contribution as natural agents for prevention of various health issues. Ethanolic extracts from the ungerminated and germinated seeds ofLupinus albusL. andLupinus angustifoliusL. were analyzed for the content in isoflavones (genistein) and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial, antiproliferative, and anti-inflammatory properties, using in vitro and in vivo tests. Germination proved to be a method of choice in increasing the amount of genistein and cinnamic acid derivatives in bothLupinus albusL. andLupinus angustifolius L.seeds. Biological evaluation of all vegetal extracts revealed a weak therapeutic potential for both ungerminated and germinated seeds.

scholarly journals Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1618-1630 ◽  
Author(s):  
Sivaprasad Kasturi ◽  
Sujatha Surarapu ◽  
Chandra Chary Bathoju ◽  
Srinivas Uppalanchi ◽  
Shubham Dwivedi ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Inhibitory Activity ◽  
Biological Evaluation ◽  
Reference Standards ◽  
Glucosidase Inhibitors ◽  
Acid Catalyzed

An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards.

A series of cinnamic acid derivatives and their inhibitory activity on intestinal α-glucosidase

2009 ◽  
Vol 24 (5) ◽  
pp. 1194-1200 ◽  
Author(s):  
Sirichai Adisakwattana ◽  
Praew Chantarasinlapin ◽  
Haruthai Thammarat ◽  
Sirintorn Yibchok-Anun
Keyword(s):  
Cinnamic Acid ◽  
Inhibitory Activity ◽  
Cinnamic Acid Derivatives

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Chiral Thiosemicarbazone Derivatives as Potent Anticancer Agents

Chirality ◽  
2014 ◽  
Vol 27 (2) ◽  
pp. 177-188 ◽  
Author(s):  
Demet Taşdemir ◽  
Ayşegül Karaküçük-İyidoğan ◽  
Mustafa Ulaşli ◽  
Tuğba Taşkin-Tok ◽  
Emİne Elçİn Oruç-Emre ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Biological Evaluation
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