Dually functionalized dendrimers by temperature-sensitive surface modification and gold nanoparticle loading for biomedical application

RSC Advances ◽  
2014 ◽  
Vol 4 (53) ◽  
pp. 27811-27819 ◽  
Author(s):  
Kenji Kono ◽  
Keishi Takeda ◽  
Xiaojie Li ◽  
Eiji Yuba ◽  
Atsushi Harada ◽  
...  
Keyword(s):  
Surface Modification ◽  
Gold Nanoparticle ◽  
Diethylene Glycol ◽  
Biomedical Application ◽  
Pamam Dendrimers ◽  
Au Nanoparticle ◽  
Temperature Sensitive ◽  
New Type ◽  
Stimuli Sensitive

Stimuli-sensitive dendrimers of a new type were developed through dual functionalization of polyamidoamine (PAMAM) dendrimers with temperature-sensitive surface modification using propoxy diethylene glycol (PDEG) and Au nanoparticle (AuNP) loading.

scholarly journals Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jiang Ouyang ◽  
Ling Zhang ◽  
Leijiao Li ◽  
Wei Chen ◽  
Zhongmin Tang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Density Functional ◽  
Biomedical Application ◽  
Density Functional Theory Calculations ◽  
Free Electrons ◽  
Functional Theory ◽  
New Approach ◽  
New Type ◽  
Average Size ◽  
Cancer Theranostics

Abstract Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

Hematite Surface Modification toward Efficient Sunlight-Driven Water Splitting Activity: The Role of Gold Nanoparticle Addition

2020 ◽  
Vol 124 (11) ◽  
pp. 6171-6179 ◽  
Author(s):  
Aryane Tofanello ◽  
Andre L. M. Freitas ◽  
Waldemir M. Carvalho ◽  
Turkka Salminen ◽  
Tapio Niemi ◽  
...  
Keyword(s):  
Surface Modification ◽  
Gold Nanoparticle ◽  
Water Splitting

Photothermal self-healing of gold nanoparticle–polystyrene hybrids

Nanoscale ◽  
2020 ◽  
Vol 12 (40) ◽  
pp. 20726-20736
Author(s):  
Yi Je Cho ◽  
Lingchen Kong ◽  
Rezawana Islam ◽  
Meitong Nie ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Au Nanoparticle ◽  
Self Healing ◽  
Particle Agglomeration ◽  
Healing Efficiency

Photothermal self-healing efficiency increased with Au nanoparticle contents and particle agglomeration deteriorated the efficiency.

scholarly journals Multivalent Lactose–Ferrocene Conjugates Based on Poly (Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 203 ◽  
Author(s):  
Manuel C. Martos-Maldonado ◽  
Indalecio Quesada-Soriano ◽  
Luis García-Fuentes ◽  
Antonio Vargas-Berenguel
Keyword(s):  
Gold Nanoparticles ◽  
Surface Modification ◽  
Cardiac Remodeling ◽  
Building Blocks ◽  
Differential Pulse ◽  
Pamam Dendrimers ◽  
Titration Calorimetry ◽  
Vis Spectroscopy ◽  
Galectin 3 ◽  
Pulse Voltammetry

Galectin-3 is considered a cancer biomarker and bioindicator of fibrosis and cardiac remodeling and, therefore, it is desirable to develop convenient methods for its detection. Herein, an approach based on the development of multivalent electrochemical probes with high galectin-3 sensing abilities is reported. The probes consist of multivalent presentations of lactose–ferrocene conjugates scaffolded on poly (amido amine) (PAMAM) dendrimers and gold nanoparticles. Such multivalent lactose–ferrocene conjugates are synthesized by coupling of azidomethyl ferrocene–lactose building blocks on alkyne-functionalized PAMAM, for the case of the glycodendrimers, and to disulfide-functionalized linkers that are then used for the surface modification of citrate-stabilized gold nanoparticles. The binding and sensing abilities toward galectin-3 of both ferrocene-containing lactose dendrimers and gold nanoparticles have been evaluated by means of isothermal titration calorimetry, UV–vis spectroscopy, and differential pulse voltammetry. The highest sensitivity by electrochemical methods to galectin-3 was shown by lactosylferrocenylated gold nanoparticles, which are able to detect the lectin in nanomolar concentrations.

Highly conductive electrocatalytic gold nanoparticle-assembled carbon fiber electrode for high-performance glucose-based biofuel cells

2019 ◽  
Vol 7 (22) ◽  
pp. 13495-13505 ◽  
Author(s):  
Cheong Hoon Kwon ◽  
Yongmin Ko ◽  
Dongyeeb Shin ◽  
Seung Woo Lee ◽  
Jinhan Cho
Keyword(s):  
Carbon Fiber ◽  
Gold Nanoparticle ◽  
High Power ◽  
High Performance ◽  
Biofuel Cells ◽  
Au Nanoparticle ◽  
Layer By Layer ◽  
Carbon Fiber Electrodes ◽  
Carbon Fiber Electrode ◽  
Fiber Electrode

Au nanoparticle-coated highly conductive carbon fiber electrodes for high-power glucose-biofuel cells were developed based on a layer-by-layer assembling method.

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