Brownian motion retarded polymer-encapsulated liquid crystal droplets anchored over a patterned substrate via click chemistry

RSC Advances ◽  
2014 ◽  
Vol 4 (52) ◽  
pp. 27135-27139 ◽  
Author(s):  
Arun Prakash Upadhyay ◽  
Prasenjit Sadhukhan ◽  
Sudeshna Roy ◽  
Raj Ganesh S Pala ◽  
Sri Sivakumar
Keyword(s):  
Brownian Motion ◽  
Liquid Crystal ◽  
Click Chemistry ◽  
Triazole Ring ◽  
Patterned Substrate

Formation of a five-membered strong triazole ring to facilitate the highly stable anchoring of LC droplet encapsulated polymer capsules over a patterned substrate.

A sulfur(vi) fluoride exchange click chemistry approach towards main chain liquid crystal polymers bearing sulfate ester groups

2019 ◽  
Vol 10 (26) ◽  
pp. 3657-3664
Author(s):  
Meng Wang ◽  
Hong-Sheng Jin ◽  
Xu-Man Chen ◽  
Bao-Ping Lin ◽  
Hong Yang
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry ◽  
Main Chain ◽  
Liquid Crystal Polymers ◽  
Sulfate Ester

Here we report a sulfur(vi) fluoride exchange click chemistry approach towards the synthesis of main chain liquid crystal polymers.

Synthesis and self-assembly behaviours of side-chain smectic thiol–ene polymers based on the polysiloxane backbone

2016 ◽  
Vol 4 (7) ◽  
pp. 1425-1440 ◽  
Author(s):  
Wenhuan Yao ◽  
Yanzi Gao ◽  
Xiao Yuan ◽  
Baofeng He ◽  
Haifeng Yu ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry ◽  
Self Assembly ◽  
Side Chain ◽  
Liquid Crystal Polymers ◽  
Different Types

A series of novel chiral polysiloxane side chain liquid crystal polymers (PSCLCPs) with two different types of LC phases and three self-assembly arrangements were successfully synthesized via thiol–ene click chemistry.

scholarly journals SYNTHESIS OF A 1,2,3-TRIAZOLE-CONTAINING MACROCYCLE BASED ON THE "CLICK CHEMISTRY" REACTION AND ANALYSIS OF ITS PLANAR CHIRALITY USING NMR AND DFT CALCULATIONS

2020 ◽  
pp. 55-61
Author(s):  
H. Yampolska ◽  
S. Kharchenko ◽  
A. Kozytskyi ◽  
A. Kyrylchuk ◽  
Z. Voitenko ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Click Chemistry ◽  
Protein Interactions ◽  
Variable Temperature ◽  
Triazole Ring ◽  
Building Blocks ◽  
Ring Closure ◽  
Amide Bond ◽  
High Yield ◽  
Planar Chirality

Macrocycles represent previously unexplored promising drug candidates, that can be useful for treating protein-protein interactions. Atropoisomerism is an inherent feature of the natural macrocyclic peptides that is significant for their activity and selectivity, and, therefore, should be introduced into newly synthesized macrocycles. Synthesis of the libraries of artificial macrocycles faces many challenges due to their structure and size. Herein we report on the preparation of a 16-membered macrocycle containing 1,2,3-triazole ring, spiro-piperidine, and phenyl moieties, as well as a chiral carbon atom. Our approach to the macrocycle was inspired by the "build/couple/pair" (B/C/P) strategy, a part of diversity-oriented synthesis methodology. We have employed readily accessible starting materials and robust synthetic procedures which allowed us to obtain the target macrocycle in a high yield. Standard methods of amide bond formation were used for the coupling of macrocycle building blocks. Click chemistry azide-alkyne cycloaddition was exploited at the final ring closure step. The assignment of signals in 1H and 13C NMR spectra of the macrocycle was performed using a series of 2D NMR techniques. The macrocycle displayed planar chirality, which, in a combination with a stereocenter with the known configuration, was sufficient to propose possible structures of diastereomers. The diastereomers could differ by the relative position of triazole ring. Their racemization could occur through a "rope skipping" motion involving the cyclic chain crossing the plane of 1,2,3-triazole ring. The supposed structures of diastereomers were corroborated by means of a various NMR spectroscopy techniques and DFT calculations. Analysis of the amide NH chemical shift temperature coefficients coupled with the data on optimized geometries obtained by DFT convincingly demonstrated that the intramolecular hydrogen bonds play a major role in stabilization of the diastereomer structures. According to the variable temperature NMR experiment, the interconversion of two diastereomers did not occur even at heating up to 70 °C.

scholarly journals Phase transition and dewetting of a 5CB liquid crystal thin film on a topographically patterned substrate

RSC Advances ◽  
2019 ◽  
Vol 9 (38) ◽  
pp. 21685-21694 ◽  
Author(s):  
Palash Dhara ◽  
Rabibrata Mukherjee
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Phase Transition ◽  
Liquid Crystal ◽  
Patterned Substrates ◽  
Thermally Induced ◽  
Patterned Substrate ◽  
5Cb Liquid Crystal

Thermally induced nematic to isotropic (N–I) phase transition and dewetting of 5CB liquid crystal thin films on flat and topographically patterned substrates.

Bistable Characteristics of Liquid Crystal Devices with Patterned Alignment Films

2011 ◽  
Vol 264-265 ◽  
pp. 1752-1757 ◽  
Author(s):  
Jais Bin Lias ◽  
Munehiro Kimura ◽  
Tadashi Akahane
Keyword(s):  
Liquid Crystal ◽  
Uv Light ◽  
Polarized Light ◽  
Mechanical Damage ◽  
Single Step ◽  
Patterned Substrate ◽  
Electrostatic Charges ◽  
Linearly Polarized ◽  
Polyimide Coating ◽  
Homeotropic Alignment

The photoalignment technology for the alignment of liquid crystal molecules has lately gathered much attention because its advantages over the conventional rubbing of polyimide coating and several different approaches for the realization of photoalignment have been presented. Due to its non-contact nature, a photoalignment eliminates generation of dust and electrostatic charges as well as mechanical damage to the surface. Up to now, the study of the photoalignment effect has been focused mostly on uniform substrates through linearly polarized light. With the aim to achieve such a bistable liquid crystal device by means of unpolarized UV light, we have proposed a single-step laser patterning on a photoalignment layer using a photomask to achieve an equilibrium configuration of LC molecules in contact with a periodically patterned substrate. The patterns were formed by stripes of alternating random planar and homeotropic anchoring in a sub-micron scale on the order of 0.5 micron. We proposed two possible configurations of bistable LC cells that can be obtained by combination of micro-patterned surface formed with alternating random planar alignment with either planar alignment or homeotropic alignment surfaces. In this study, we have investigated the alignment properties and switching behaviours of both proposed models.

Mono-Disperse Triphenylene Discotic Liquid Crystal Oligomers Synthesized by Click Chemistry

2013 ◽  
Vol 17 (8) ◽  
pp. 871-885 ◽  
Author(s):  
Yue-Feng Bai ◽  
Ke-Qing Zhao ◽  
Ping Hu ◽  
Bi-Qin Wang ◽  
Carl Redshaw
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry ◽  
Discotic Liquid Crystal

Synthesis of disk-rod-disk liquid crystal trimers by using click chemistry

2010 ◽  
Vol 40 (5) ◽  
pp. 467-475
Author(s):  
ShiChang NIE ◽  
KeQing ZHAO ◽  
YueFeng BAI ◽  
Ping HU ◽  
WenHao YU ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry

scholarly journals Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Andrew McGown ◽  
Abby Ragazzon-Smith ◽  
John A. Hadfield ◽  
Herman Potgetier ◽  
Patricia A. Ragazzon
Keyword(s):  
Anticancer Activity ◽  
Click Chemistry ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Triazole Ring ◽  
Microwave Assisted Synthesis ◽  
Anticancer Properties ◽  
Microwave Assisted ◽  
Ic50 Values ◽  
High Yields

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

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