Synthesis of medicinally important quinazolines decorated with 1,4-disubstituted-1,2,3-triazoles using CuSO4·5H2O–Et3N catalytic system
Keyword(s):
System P
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The direct use of Cu(ii) sulfate pentahydrate in the presence of triethylamine afforded 1,4-disubstituted-1,2,3-triazoles via 1,3-dipolar cycloaddition of terminal alkyne(s) to azide(s) at room temperature.