The vicinal functionalization of olefins: a facile route to the direct synthesis of β-chlorohydrins and β-chloroethers

RSC Advances ◽  
2014 ◽  
Vol 4 (50) ◽  
pp. 26288-26294 ◽  
Author(s):  
Peraka Swamy ◽  
Macharla Arun Kumar ◽  
Marri Mahender Reddy ◽  
Mameda Naresh ◽  
Kodumuri Srujana ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Direct Synthesis ◽  
Green Approach ◽  
Chloro Derivatives ◽  
Facile Route

A general and green approach for the highly regio- and stereoselective synthesis of α-hydroxy-β-chloro and α-methoxy-β-chloro derivatives from olefins using inexpensive and industrially acceptable reagents is reported.

Mechanochemistry – a new powerful green approach to the direct synthesis of alkoxysilanes

2018 ◽  
Vol 20 (9) ◽  
pp. 1962-1969 ◽  
Author(s):  
Maxim N. Temnikov ◽  
Anton A. Anisimov ◽  
Pavel V. Zhemchugov ◽  
Dmitry N. Kholodkov ◽  
Alexander S. Goloveshkin ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Mechanochemical Method ◽  
One Stage ◽  
Green Approach

The present work shows a new one-stage mechanochemical method for the direct synthesis of alkoxysilanes.

ChemInform Abstract: The Vicinal Functionalization of Olefins: A Facile Route to the Direct Synthesis of β-Chlorohydrins and β-Chloroethers.

ChemInform ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. no-no
Author(s):  
Peraka Swamy ◽  
Macharla Arun Kumar ◽  
Marri Mahender Reddy ◽  
Mameda Naresh ◽  
Kodumuri Srujana ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Facile Route

scholarly journals Metal- and Base-Free Electrophilic Addition of 3-Diazooxindoles with H-phosphine Oxides for N–P Bond Formation

2018 ◽  
Vol 42 (2) ◽  
pp. 63-67 ◽  
Author(s):  
Xiu Gu ◽  
Peng Xie ◽  
Jun Jiang ◽  
Yi Wu ◽  
Lisheng Wang
Keyword(s):  
Stereoselective Synthesis ◽  
Bond Formation ◽  
Electrophilic Addition ◽  
Diazo Compounds ◽  
Phosphorus Compounds ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Highly Efficient ◽  
Green Approach

A highly efficient electrophilic addition of 3-diazooxindoles to H-phosphine oxides under metal-free and base-free conditions is established, leading to phosphinic hydrazides. This method has good chemoselectivity and broad substrate diversity, and provides a facile and green approach for N–P bond formation. The stereoselective synthesis represents a unique example of asymmetric electrophilic addition of diazo compounds as N-terminal electrophiles with phosphorus compounds, affording P-stereogenic phosphinic hydrazides with excellent stereoselectivity.

scholarly journals Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles

2012 ◽  
Vol 8 ◽  
pp. 567-578 ◽  
Author(s):  
Pavol Jakubec ◽  
Dane M Cockfield ◽  
Madeleine Helliwell ◽  
James Raftery ◽  
Darren J Dixon
Keyword(s):  
Michael Addition ◽  
Stereoselective Synthesis ◽  
Direct Synthesis ◽  
One Pot

A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised in a four component one-pot reaction combining an enantioselective organocatalytic Michael addition with the diastereoselective nitro-Mannich/lactamisation cascade. Protodenitration and chemoselective reductive manipulation of the heterocycles was used to install contiguous and fully substituted stereocentres in the synthesis of substituted piperidines.

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