Hyaluronic acid–siRNA conjugates complexed with cationic solid lipid nanoparticles for target specific gene silencing

RSC Advances ◽  
2014 ◽  
Vol 4 (37) ◽  
pp. 19338-19344 ◽  
Author(s):  
Min-Young Lee ◽  
Won Ho Kong ◽  
Ho Sang Jung ◽  
Sei Kwang Hahn
Keyword(s):  
Hyaluronic Acid ◽  
Gene Silencing ◽  
Solid Lipid Nanoparticles ◽  
Transfection Efficiency ◽  
Lipid Nanoparticles ◽  
Specific Gene ◽  
Solid Lipid ◽  
Dual Targeting ◽  
Low Cytotoxicity ◽  
Targeting Effect

The reducible hyaluronic acid (HA)–siRNA conjugates complexed with cationic solid lipid nanoparticles (CSLNs) with low cytotoxicity and high transfection efficiency was successfully developed for effective liver-specific gene silencing by the dual targeting effect of HA and CSLN.

A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases

2014 ◽  
Vol 465 (1-2) ◽  
pp. 413-426 ◽  
Author(s):  
Paola Stephanie Apaolaza ◽  
Diego Delgado ◽  
Ana del Pozo-Rodríguez ◽  
Alicia Rodríguez Gascón ◽  
M.Ángeles Solinís
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Diseases ◽  
Gene Therapy Vector ◽  
Solid Lipid ◽  
Novel Gene

Low cytotoxicity of solid lipid nanoparticles inin vitroandex vivolung models

2009 ◽  
Vol 21 (sup1) ◽  
pp. 104-109 ◽  
Author(s):  
Matthias Nassimi ◽  
Carsten Schleh ◽  
Hans-Dieter Lauenstein ◽  
Riem Hussein ◽  
Katrin Lübbers ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Low Cytotoxicity

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

2014 ◽  
Vol 114 ◽  
pp. 407-415 ◽  
Author(s):  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Thiruganesh Ramasamy ◽  
Duy Hieu Truong ◽  
Chien Ngoc Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration

2013 ◽  
Vol 85 (3) ◽  
pp. 488-502 ◽  
Author(s):  
Susana M. Martins ◽  
Bruno Sarmento ◽  
Cláudia Nunes ◽  
Marlene Lúcio ◽  
Salette Reis ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Solid Lipid ◽  
Targeting Effect

Inclusion of the Helper Lipid Dioleoyl-Phosphatidylethanolamine in Solid Lipid Nanoparticles Inhibits Their Transfection Efficiency

2014 ◽  
Vol 10 (2) ◽  
pp. 355-365 ◽  
Author(s):  
Marcelo B. de Jesus ◽  
Allan Radaic ◽  
Wouter L. J. Hinrichs ◽  
Carmen V. Ferreira ◽  
Eneida De Paula ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Transfection Efficiency ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Coating Solid Lipid Nanoparticles with Hyaluronic Acid Enhances Antitumor Activity against Melanoma Stem-like Cells

Theranostics ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 755-771 ◽  
Author(s):  
Hongxin Shen ◽  
Sanjun Shi ◽  
Zhirong Zhang ◽  
Tao Gong ◽  
Xun Sun
Keyword(s):  
Hyaluronic Acid ◽  
Antitumor Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 716-722 ◽  
Author(s):  
Meiling Zhou ◽  
Jierong Hou ◽  
Zhirong Zhong ◽  
Na Hao ◽  
Yan Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid
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