scholarly journals Click chemistry facilitates direct labelling and super-resolution imaging of nucleic acids and proteins

RSC Advances ◽  
2014 ◽  
Vol 4 (57) ◽  
pp. 30462-30466 ◽  
Author(s):  
Anika Raulf ◽  
Christoph K. Spahn ◽  
Patrick J. M. Zessin ◽  
Kieran Finan ◽  
Stefan Bernhardt ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Super Resolution ◽  
Direct Labelling ◽  
Resolution Imaging

scholarly journals Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12247-12254 ◽  
Author(s):  
Kim-A. Saal ◽  
Frank Richter ◽  
Peter Rehling ◽  
Silvio O. Rizzoli
Keyword(s):  
Amino Acids ◽  
Click Chemistry ◽  
Unnatural Amino Acids ◽  
Super Resolution ◽  
Dual Color ◽  
Combined Use ◽  
Resolution Imaging

Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging

2018 ◽  
Vol 130 (50) ◽  
pp. 16602-16607 ◽  
Author(s):  
Franziska Neubert ◽  
Gerti Beliu ◽  
Ulrich Terpitz ◽  
Christian Werner ◽  
Christian Geis ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Click Chemistry ◽  
Super Resolution ◽  
Fluorescence Labeling ◽  
Site Specific ◽  
Specific Fluorescence ◽  
Resolution Imaging

scholarly journals Click-ExM enables expansion microscopy for all biomolecules

2020 ◽  
Author(s):  
De-en Sun ◽  
Xinqi Fan ◽  
Hao Zhang ◽  
Zhimin Huang ◽  
Qi Tang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Signal Amplification ◽  
Super Resolution ◽  
Cellular Imaging ◽  
One Stop ◽  
Nanoscale Imaging ◽  
Resolution Imaging

Expansion microscopy (ExM) allows super-resolution imaging on conventional fluorescence microscopes, but has been limited to proteins and nucleic acids. Here we develop click-ExM, which integrates click-labeling into ExM to enable a “one-stop-shop” method for nanoscale imaging of various types of biomolecules. Using 18 clickable labels for click-ExM imaging of DNA, RNA, proteins, lipids, glycans and small molecules, we demonstrate its universality, compatibility with signal-amplification techniques, and broad applications in cellular imaging.

Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging

2018 ◽  
Vol 57 (50) ◽  
pp. 16364-16369 ◽  
Author(s):  
Franziska Neubert ◽  
Gerti Beliu ◽  
Ulrich Terpitz ◽  
Christian Werner ◽  
Christian Geis ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Click Chemistry ◽  
Super Resolution ◽  
Fluorescence Labeling ◽  
Site Specific ◽  
Specific Fluorescence ◽  
Resolution Imaging
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