Synthesis of drug-crosslinked polymer nanoparticles

2015 ◽  
Vol 6 (10) ◽  
pp. 1703-1713 ◽  
Author(s):  
Chen Xie ◽  
Chenchen Yang ◽  
Peng Zhang ◽  
Jialiang Zhang ◽  
Wei Wu ◽  
...  
Keyword(s):  
Diblock Copolymer ◽  
Phenylboronic Acid ◽  
Polymer Nanoparticles ◽  
Ester Bond ◽  
Polymer Nanoparticle ◽  
Crosslinked Polymer

A new kind of drug-crosslinked polymer nanoparticle was synthesized. The nanoparticles were composed by a phenylboronic acid modified 10-hydroxycamptothecin (the crosslinker) and 1,2-diol-rich PEG-PGMA diblock copolymer (the backbone), and crosslinked by phenylboronic ester bond.

Preparation of Pt(iv)-crosslinked polymer nanoparticles with an anti-detoxifying effect for enhanced anticancer therapy

2017 ◽  
Vol 8 (15) ◽  
pp. 2410-2422 ◽  
Author(s):  
Zihao Zhang ◽  
Yongjing Li ◽  
Jiaxun Wan ◽  
Peihua Long ◽  
Jia Guo ◽  
...  
Keyword(s):  
Anticancer Therapy ◽  
Polymer Nanoparticles ◽  
High Loading ◽  
Uniform Size ◽  
Polymer Nanoparticle ◽  
Crosslinked Polymer

A new kind of Pt(iv)-crosslinked polymer nanoparticle with small, uniform size and high loading of cisplatin has been prepared for greatly attenuating the detoxifying effect of Pt(ii) species.

Glucose-sensitive polymer nanoparticles for self-regulated drug delivery

2016 ◽  
Vol 52 (49) ◽  
pp. 7633-7652 ◽  
Author(s):  
Li Zhao ◽  
Chunsheng Xiao ◽  
Liyan wang ◽  
Guangqing Gai ◽  
Jianxun Ding
Keyword(s):  
Drug Delivery ◽  
Glucose Oxidase ◽  
Concanavalin A ◽  
Phenylboronic Acid ◽  
Polymer Nanoparticles

Glucose-sensitive polymer nanoparticles based on glucose oxidase, concanavalin A, or phenylboronic acid for self-regulated drug delivery have been reviewed.

scholarly journals Spin-echo small-angle neutron scattering (SESANS) studies of diblock copolymer nanoparticles

Soft Matter ◽  
2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Gregory N. Smith ◽  
Victoria J. Cunningham ◽  
Sarah L. Canning ◽  
Matthew J. Derry ◽  
J. F. K. Cooper ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Diblock Copolymer ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
Spin Echo ◽  
Real Space ◽  
Polymer Nanoparticles ◽  
High Contrast ◽  
Concentrated Dispersions

Concentrated dispersions of polymer nanoparticles with high contrast can be studied using SESANS in real space.

cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

2020 ◽  
Vol 11 (4) ◽  
pp. 889-899 ◽  
Author(s):  
Chunhui Gao ◽  
Yinghua Zhang ◽  
Yan Zhang ◽  
Shaoyong Li ◽  
Xinlin Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contrast Agent ◽  
Disulfide Bond ◽  
Polymer Nanoparticles ◽  
Targeted Imaging ◽  
Crosslinked Polymer ◽  
Ct Contrast Agent ◽  
Surface Modified ◽  
Ct Contrast

The disulfide bond-crosslinked polymer nanoparticles based on iopamidol were prepared and then surface-modified with cRGD peptide through the linkages of PEG to acquire a CT contrast agent for breast cancer-targeted imaging.

scholarly journals Nanoparticle-enhanced fluorescence emission for non-separation assays of carbohydrates using a boronic acid–alizarin complex

2016 ◽  
Vol 52 (18) ◽  
pp. 3701-3704 ◽  
Author(s):  
Qianjin Li ◽  
Tripta Kamra ◽  
Lei Ye
Keyword(s):  
Boronic Acid ◽  
Fluorescence Emission ◽  
Polymer Nanoparticles ◽  
Significant Enhancement ◽  
Enhanced Fluorescence ◽  
Crosslinked Polymer ◽  
P Addition

Addition of crosslinked polymer nanoparticles into a solution of a 3-nitrophenylboronic acid–alizarin complex leads to significant enhancement of fluorescence emission.

Dual responsive Pickering emulsions stabilized by constructed core crosslinked polymer nanoparticles via reversible covalent bonds

Soft Matter ◽  
2016 ◽  
Vol 12 (48) ◽  
pp. 9683-9691 ◽  
Author(s):  
Huazhang Guo ◽  
Duanguang Yang ◽  
Mei Yang ◽  
Yong Gao ◽  
Yijiang Liu ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Pickering Emulsions ◽  
Covalent Bonds ◽  
Crosslinked Polymer ◽  
Dual Responsive ◽  
Reversible Covalent

scholarly journals Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Hongyun Ma ◽  
Weiqian Jiang ◽  
Jianxun Ding ◽  
Mingqiang Li ◽  
Yilong Cheng ◽  
...  
Keyword(s):  
Synergetic Effect ◽  
Polymer Nanoparticles ◽  
Spinal Tumors ◽  
Wide Resection ◽  
High Morbidity ◽  
Polymer Nanoparticle ◽  
Adjacent Structures ◽  
Vascular Structures ◽  
Stimuli Response

Malignant spinal tumors, categorized into primary and metastatic ones, are one of the most serious diseases due to their high morbidity and mortality rates. Common primary spinal tumors include chordoma, chondrosarcoma, osteosarcoma, Ewing’s sarcoma, and multiple myeloma. Spinal malignancies are not only locally invasive and destructive to adjacent structures, such as bone, neural, and vascular structures, but also disruptive to distant organs (e.g., lung). Current treatments for spinal malignancies, including wide resection, radiotherapy, and chemotherapy, have made significant progress like improving patients’ quality of life. Among them, chemotherapy plays an important role, but its potential for clinical application is limited by severe side effects and drug resistance. To ameliorate the current situation, various polymer nanoparticles have been developed as promising excipients to facilitate the effective treatment of spinal malignancies by utilizing their potent advantages, for example, targeting, stimuli response, and synergetic effect. This review overviews the development of polymer nanoparticles for antineoplastic delivery in the treatment of spinal malignancies and discusses future prospects of polymer nanoparticle-based treatment methods.

Crosslinked polymer nanoparticles containing single conjugated polymer chains

2017 ◽  
Vol 5 (2) ◽  
pp. 024001 ◽  
Author(s):  
Rodrigo A Ponzio ◽  
Yésica L Marcato ◽  
María L Gómez ◽  
Carolina V Waiman ◽  
Carlos A Chesta ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Polymer Chains ◽  
Polymer Nanoparticles ◽  
Crosslinked Polymer ◽  
Conjugated Polymer Chains
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