Chitosan oligosaccharide copolymer micelles with double disulphide linkage in the backbone associated by H-bonding duplexes for targeted intracellular drug delivery

2015 ◽  
Vol 6 (9) ◽  
pp. 1454-1464 ◽  
Author(s):  
Qinglai Yang ◽  
Changyu He ◽  
Yuhong Xu ◽  
Bingya Liu ◽  
Zhifeng Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Block Copolymer ◽  
Chitosan Oligosaccharide ◽  
Intracellular Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Folic acid conjugated block copolymer micelles with H-bonding associated double disulphide linkage in the backbone were developed.

K+ -Responsive Block Copolymer Micelles for Targeted Intracellular Drug Delivery

2017 ◽  
Vol 17 (9) ◽  
pp. 1700143 ◽  
Author(s):  
Shan Yan ◽  
Lin-Yan Wan ◽  
Xiao-Jie Ju ◽  
Jiang-Feng Wu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Intracellular Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

scholarly journals Assessment of Intracellular Delivery Potential of Novel Sustainable Poly(δ-decalactone)-Based Micelles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 726
Author(s):  
Kuldeep Kumar Bansal ◽  
Ezgi Özliseli ◽  
Gaurav Kumar Saraogi ◽  
Jessica M. Rosenholm
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Folate Receptor ◽  
In Vitro Cytotoxicity ◽  
Uptake Efficiency ◽  
Drug Delivery Carrier ◽  
Intracellular Drug Delivery ◽  
Copolymer Micelles ◽  
Model Drug

Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular drug delivery potential is not yet investigated and therefore, in this work, we report on the synthesis and cellular uptake efficiency of poly(δ-decalactone) based micelles with or without a targeting ligand. Folic acid was chosen as a model targeting ligand and Rhodamine B as a fluorescent tracer to demonstrate the straightforward functionalisation aspect of copolymers. The synthesis of block copolymers was accomplished by a combination of facile ring-opening polymerisation and click chemistry to retain the structure uniformity. The presence of folic acid on the surface of micelles with diameter ~150 nm upsurge the uptake efficiency by 1.6 fold on folate receptor overexpressing MDA-MB-231 cells indicating the attainment of targeting using ligand functionality. The drug delivery capability of these carriers was ascertained by using docetaxel as a model drug, whereby the in vitro cytotoxicity of the drug was significantly increased after incorporation in micelles 48 h post incubation. We have also investigated the possible endocytosis route of non-targeted micelles and found that caveolae-mediated endocytosis was the preferred route of uptake. This work strengthens the prospect of using novel bio-based poly(δ-decalactone) micelles as efficient multifunctional drug delivery nanocarriers towards medical applications.

Pickering emulsions stabilized by biodegradable block copolymer micelles for controlled topical drug delivery

2017 ◽  
Vol 531 (1) ◽  
pp. 134-142 ◽  
Author(s):  
Faiza Laredj-Bourezg ◽  
Marie-Alexandrine Bolzinger ◽  
Jocelyne Pelletier ◽  
Yves Chevalier
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Topical Drug Delivery ◽  
Pickering Emulsions ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Disulfide cross-linked cholic-acid modified PEG–poly(amino acid) block copolymer micelles for controlled drug delivery of doxorubicin

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 30380-30388 ◽  
Author(s):  
Yuling Li ◽  
Yuling Shen ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Block Copolymer ◽  
Cholic Acid ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Doxorubicin Release

Reduction responsive biodegradable core-cross-linked micelles are developed form lipoic acid and cholic acid decorated poly(ethylene glycol)-b-poly(l-glutamic acid) block copolymers and investigated for intracellular doxorubicin release.

Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery

2016 ◽  
Vol 5 (19) ◽  
pp. 2493-2499 ◽  
Author(s):  
Dongfang Zhou ◽  
Jinshan Guo ◽  
Gloria B. Kim ◽  
Jizhen Li ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles
Sign in / Sign up

Export Citation Format

Share Document