Polyurethane-coated silica particles with broad-spectrum antibacterial properties

2015 ◽  
Vol 6 (11) ◽  
pp. 2011-2022 ◽  
Author(s):  
Qingxing Xu ◽  
Haritz Sardon ◽  
Julian M. W. Chan ◽  
James L. Hedrick ◽  
Yi Yan Yang
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Silica Particles ◽  
End Group

Antibacterial polyurethane-coated silica particles were synthesized using a “grafting to” approach via surface-to-end-group and surface-to-backbone strategies.

scholarly journals Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399.

1992 ◽  
Vol 36 (12) ◽  
pp. 2825-2834 ◽  
Author(s):  
P Angehrn ◽  
P Hohl ◽  
C Hubschwerlen ◽  
M Page ◽  
R Then
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Properties

Antimicrobial peptides in silkworm

2019 ◽  
Vol 69 (4) ◽  
pp. 391-410 ◽  
Author(s):  
Zhi Li ◽  
Yan Ma ◽  
Xuan Liu ◽  
Yi Li ◽  
Fangyin Dai
Keyword(s):  
Antioxidant Activity ◽  
Clinical Practice ◽  
Antimicrobial Peptides ◽  
Structure Function ◽  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Vital Role ◽  
Bacteria Resistance

Abstract Antimicrobial peptides (AMPs) are a type of small molecular proteins that play a vital role in the resistance to alien pathogens. AMPs are widespread in bacteria, archaea, protists, fungi, plants and animals. AMPs have a broad spectrum of antimicrobial activities and they rarely induce bacteria resistance; thus, they are thought to be good candidates for antibiotics in clinical practice. Recently, AMPs are increasingly attracting attention because of their outstanding features and functions. In addition to their known antibacterial properties, some kinds of AMPs have also been reported to have antiviral, anticancer, antiparasitic, and antioxidant activity. In this review, we introduce the diversity of AMPs, including their structure, function and related mechanisms. We focus primarily on recent studies of silkworm AMPs and summarize their classification, activities and possible mechanisms. Finally, based on the review, probable directions and perspectives for studies of the AMPs of silkworm are discussed and proposed.

scholarly journals 3D printed zirconia ceramic hip joint with precise structure and broad-spectrum antibacterial properties

2019 ◽  
Vol Volume 14 ◽  
pp. 5977-5987 ◽  
Author(s):  
Yanglong Zhu ◽  
Kuan Liu ◽  
Jianjian Deng ◽  
Jing Ye ◽  
Fanrong Ai ◽  
...  
Keyword(s):  
Hip Joint ◽  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Zirconia Ceramic ◽  
3D Printed

scholarly journals Neo-5,22E-Cholestadienol Derivatives from Buthus martensii Karsch and Targeted Bactericidal Action Mechanisms

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 72
Author(s):  
Biyu Lv ◽  
Weiping Yin ◽  
Jiayu Gao ◽  
Huaqing Liu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Bacterial Growth ◽  
Broad Spectrum ◽  
Active Sites ◽  
Specific Binding ◽  
Antibacterial Properties ◽  
2D Nmr ◽  
Cross Resistance ◽  
Ionization Mass ◽  
Spectra Analysis ◽  
New Compounds

The discovery and search for new antimicrobial molecules from insects and animals that live in polluted environments is a very important step in the scientific search for solutions to the current problem of antibiotic resistance. Previously, we have reported that the secondary metabolite with the antibacterial action discovered in scorpion. The current study further isolated three new compounds from Buthus martensii karsch, while compounds 1 and 2 possessed 5,22E-cholestadienol derivatives whose structure demonstrated broad spectrum bactericide activities. To explore the antibacterial properties of these new compounds, the result shows that compound 2 inhibited bacterial growth of both S. aureus and P. aeruginosa in a bactericidal rather than a bacteriostatic manner (MBC/MIC ratio ≤ 2). Similarly, with compound 1, a ratio of MBC/MIC ≤ 2 indicates bactericidal activity inhibited bacterial growth of P. aeruginosa. Remarkably, this suggests that two compounds can be classified as bactericidal agents against broad spectrum bactericide activities for 5,22E-cholestadienol derivatives from Buthus martensii karsch. The structures of compounds 1–3 were established by comprehensive spectra analysis including two-dimensional nuclear magnetic resonance (2D-NMR) and high-resolution electrospray ionization-mass spectrometry (HRESI-MS) spectra. The antibacterial mechanism is the specific binding (various of bonding forces between molecules) using compound 1 or 2 as a ligand based on the different receptor proteins’—2XRL or 1Q23—active sites from bacterial ribosome unit A, and thus prevent the synthesis of bacterial proteins. This unique mechanism avoids the cross-resistance issues of other antibacterial drugs.

Synthesis and characterization of chitosan–zinc composite electrodeposits with enhanced antibacterial properties

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 46081-46088 ◽  
Author(s):  
Xiaofan Zhai ◽  
Congtao Sun ◽  
Ke Li ◽  
Fang Guan ◽  
Xueqing Liu ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Synthesis And Characterization ◽  
Bactericidal Property ◽  
Marine Application

Chitosan–zinc composite electrodeposits with enhanced broad-spectrum bactericidal property were successfully synthesized based on the chelation action for marine application.

scholarly journals Synthesis of Some Quinoxaline Sulfonamides as a Potential Antibacterial Agent

2021 ◽  
pp. 116-132
Author(s):  
Festus O. Taiwo ◽  
Craig A. Obafemi ◽  
David A. Akinpelu A. Akinpelu
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Antibacterial Property ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Pharmacological Properties ◽  
Antimicrobial Compounds ◽  
Bacterial Strains ◽  
Bactericidal Effects

Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and pharmacological properties. Objective: This study was designed to synthesized some quinoxaline-2,3-dione with sulfonamide moiety, characterize the synthesized compounds, and study the antimicrobial properties of the synthesized compounds on some bacterial strains. Materials and Methods: Six quinoxaline-6-sulfonohydrazone derivatives were synthesized by reacting quinoxaline-6-sulfonohydrazine with some substituted benzaldehydes and ketones. The compounds were tested for their potential antibacterial properties. Results: All the test compounds possessed promising antibacterial property against a panel of bacterial strains used for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. Among the compounds tested, compound 2 showed appreciable antibacterial activity. Discussion and Conclusion: The study concluded that all the compounds exhibited appreciable bactericidal effects towards all the bacterial strains, particularly, compound 2 This is an indication that such compounds possessing broad spectrum activities will be useful in formulating antimicrobial compounds which could be used to treat infections caused by pathogens that are now developing resistance against the available antibiotics.

scholarly journals Design, Synthesis, Reactions and Antibacterial Properties of 2-hydrazinyl-3-methyl-6-nitroquinoxaline Derivatives

2021 ◽  
pp. 115-127
Author(s):  
F. O. Taiwo ◽  
C.A. Obafemi ◽  
D.A. Akinpelu
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Properties ◽  
Test Organism ◽  
Bacterial Strains ◽  
Design Synthesis ◽  
Antibacterial Compounds ◽  
Synthetic Compounds ◽  
Bactericidal Effects ◽  
Synthesis Reactions

Aims: This aims of this study was to synthesis new quinoxaline-based heterocycles and study its antibacterial properties. Objective: This study was designed to synthesis some 3-methyl-6-nitroquinoxaline-2-one with hydrazine moiety, characterize the synthesized compounds, and study their antibacterial properties on some bacterial strains. Materials and Methods: Six 3-methylquinoxaline-2-hydrazone derivatives were synthesized by reacting 2-hydrazinyl-3-methyl-6-nitroquinoxaline with various substituted acetophenones. The hydrazones were screened for their potential antibacterial properties. Results: All the test compounds were found to possessed promising antibacterial properties against a panel of bacterial strains screened for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. The lowest MBC of the compounds against the test organism was 0.0625 mg/mL while the highest MBC was 0.250 mg/mL. Discussion and Conclusion: The study concluded that all the compounds exhibited appreciable bactericidal effects against all the bacterial strains, which is an indication that such synthetic compounds possessed broad spectrum activities and such compounds could be useful in formulation of antibacterial compounds which could be used to mitigates infections caused by pathogens that are now developing resistance against the available antibiotics.

Broad-Spectrum Antibacterial Properties ofThymus fallax.

2005 ◽  
Vol 43 (7) ◽  
pp. 609-613 ◽  
Author(s):  
Suzan Ozturk ◽  
Sezai Ercisli
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Properties
Sign in / Sign up

Export Citation Format

Share Document