Enhanced drug toxicity by conjugation of platinum drugs to polymers with guanidine containing zwitterionic functional groups that mimic cell-penetrating peptides

2014 ◽  
Vol 5 (22) ◽  
pp. 6600-6610 ◽  
Author(s):  
Khairil Juhanni Abd Karim ◽  
Robert H. Utama ◽  
Hongxu Lu ◽  
Martina H. Stenzel
Keyword(s):  
Functional Groups ◽  
Drug Toxicity ◽  
Cell Penetrating Peptides ◽  
Platinum Drugs ◽  
Cell Penetrating ◽  
Solubility Enhancers ◽  
Groove Binders

Inspired by the Ringsdorf model, statistical copolymers with solubility enhancers, platinum drugs and groove binders were compared.

scholarly journals Delivery of SiC-based nanoparticles into live cells driven by cell-penetrating peptides SAP and SAP-E

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20498-20502 ◽  
Author(s):  
T. Serdiuk ◽  
I. Bakanovich ◽  
V. Lysenko ◽  
S. A. Alekseev ◽  
V. A. Skryshevsky ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cell Penetrating Peptides ◽  
Live Cells ◽  
Nanoparticle Delivery ◽  
Cell Penetrating ◽  
Covalent Conjugates

Cell-penetrating peptides enhance nanoparticle delivery into cells most efficiently if surface and peptide functional groups “match” to form non-covalent conjugates.

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