Controlled polymerization of histidine and synthesis of well-defined stimuli responsive polymers. Elucidation of the structure–aggregation relationship of this highly multifunctional material

2014 ◽  
Vol 5 (21) ◽  
pp. 6256-6278 ◽  
Author(s):  
Dimitrios Mavrogiorgis ◽  
Panayiotis Bilalis ◽  
Anastasis Karatzas ◽  
Dimitrios Skoulas ◽  
Georgia Fotinogiannopoulou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Controlled Polymerization ◽  
Hybrid Polymers ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Multifunctional Material ◽  
Drug Delivery Applications ◽  
Relationship Of

Synthesis of multifunctional poly(l-histidine) containing polypeptides and hybrid polymers for controlled drug delivery applications.

Poly(ε-caprolactone) with pH and UCST responsiveness as a 5-fluorouracil carrier

2020 ◽  
Vol 11 (32) ◽  
pp. 5173-5180
Author(s):  
Shuang Zhu ◽  
Lianlei Wen ◽  
Yan Xiao ◽  
Meidong Lang
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Stimuli-responsive polymers with excellent biocompatibility and biodegradability are highly demanded as carriers for controlled drug delivery.

Molecularly Engineered Polymer-Based Systems in Drug Delivery and Regenerative Medicine

2017 ◽  
Vol 23 (2) ◽  
pp. 281-294 ◽  
Author(s):  
Susanna Piluso ◽  
Al Halifa Soultan ◽  
Jennifer Patterson
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Local Environment ◽  
Stimuli Responsive ◽  
Controlled Polymerization ◽  
Polymer Therapeutics ◽  
Protein Conjugates ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Drug Conjugates

Background: Polymer-based systems are attractive in drug delivery and regenerative medicine due to the possibility of tailoring their properties and functions to a specific application. Methods: The present review provides several examples of molecularly engineered polymer systems, including stimuli responsive polymers and supramolecular polymers. Results: The advent of controlled polymerization techniques has enabled the preparation of polymers with controlled molecular weight and well-defined architecture. By using these techniques coupled to orthogonal chemical modification reactions, polymers can be molecularly engineered to incorporate functional groups able to respond to small changes in the local environment or to a specific biological signal. This review highlights the properties and applications of stimuli-responsive systems and polymer therapeutics, such as polymer-drug conjugates, polymer-protein conjugates, polymersomes, and hyperbranched systems. The applications of polymeric membranes in regenerative medicine are also discussed. Conclusion: The examples presented in this review suggest that the combination of membranes with polymers that are molecularly engineered to respond to specific biological functions could be relevant in the field of regenerative medicine.

scholarly journals Stimuli-responsive polymers and their applications

2017 ◽  
Vol 8 (1) ◽  
pp. 127-143 ◽  
Author(s):  
Menglian Wei ◽  
Yongfeng Gao ◽  
Xue Li ◽  
Michael J. Serpe
Keyword(s):  
Drug Delivery ◽  
Physical Properties ◽  
Artificial Muscles ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Responsive Polymer ◽  
External Stimuli

Responsive polymer-based materials are capable of altering their chemical and/or physical properties upon exposure to external stimuli. This review highlights their use for sensing and biosensing, drug delivery, and artificial muscles/actuators.

Stimuli-responsive polymers and their applications in drug delivery

2009 ◽  
Vol 4 (2) ◽  
pp. 022001 ◽  
Author(s):  
Priya Bawa ◽  
Viness Pillay ◽  
Yahya E Choonara ◽  
Lisa C du Toit
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

2019 ◽  
Vol 10 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Sharon Kunnath Joseph ◽  
Mangalath Sabitha ◽  
Sreeja Chandrasekharan Nair
Keyword(s):  
Drug Delivery ◽  
Chemical Change ◽  
Specific Drug ◽  
Stimuli Responsive ◽  
Diagnostic Systems ◽  
Nanodrug Delivery ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Environment Temperature ◽  
Colon Specific Drug Delivery

An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Stimuli responsive polymers display a significant physio chemical change in response to small changes in their environment (temperature, pH, light etc.). Colonic drug delivery has gained increased importance in treating diseases like Crohn’s disease, ulcerative colitis, colon cancer etc. The expansion in the development of polymers based system with greater flexibility, versatility and unexplored potential enables new opportunities for them in uplifting bio medicine. Applying the concepts of smartness in the context of clinically relevant therapeutic and diagnostic systems, it can prelude in a new era of ‘smart’ therapeutics that can improve the health care fields. In particular, due to its high sensitivity to the stimuli, this system has been identified as a sensible platform for releasing drug at suitable site and at appropriate time.

scholarly journals Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

2019 ◽  
Vol 9 (5) ◽  
pp. 825 ◽  
Author(s):  
Nemany Hanafy ◽  
Stefano Leporatti ◽  
Maged El-Kemary
Keyword(s):  
Drug Delivery ◽  
Biological Activity ◽  
Mammalian Cells ◽  
Biomedical Applications ◽  
Biological Fluids ◽  
Medical Applications ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Hydrogel Formulation

Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses, bacteria, and mammalian cells. Indeed, many methods have been published which are used in hydrogel formulation and biomedical encapsulations involving several cross-linkers. This system is still rich with the potential of undiscovered features. The physicochemical properties of polymers, distinguished by their interactions with biological systems into mucoadhesive, gastro-adhesive, and stimuli responsive polymers. Hydrogel systems may be assembled as tablets, patches, gels, ointments, and films. Their potential to be co-formulated as nanoparticles extends the limits of their assembly and application. In this review, mucoadhesive nanoparticles and their importance for biomedical applications are highlighted with a focus on mechanisms of overcoming mucosal resistance.

scholarly journals Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

2020 ◽  
Vol 11 (44) ◽  
pp. 6988-7008 ◽  
Author(s):  
Duc Dung Nguyen ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disease Treatment ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Stimuli Response

Recent exploitations of stimuli-responsive polymers as ophthalmic drug delivery systems for the treatment of eye diseases are summarized and discussed.

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