Dendrimer–doxorubicin conjugate as enzyme-sensitive and polymeric nanoscale drug delivery vehicle for ovarian cancer therapy

2014 ◽  
Vol 5 (18) ◽  
pp. 5227-5235 ◽  
Author(s):  
Chengyuan Zhang ◽  
Dayi Pan ◽  
Kui Luo ◽  
Ning Li ◽  
Chunhua Guo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Antitumor Activity ◽  
Click Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Tissue ◽  
Delivery Vehicle ◽  
High Accumulation

Dendrimer–doxorubicin conjugate prepared via click chemistry was employed as enzyme-sensitive nanoscale drug delivery system for ovarian cancer therapy, showing high accumulation in tumor tissue, significantly increased antitumor activity and good biosafety.

A stimuli-responsive Janus peptide dendron–drug conjugate as a safe and nanoscale drug delivery vehicle for breast cancer therapy

2016 ◽  
Vol 4 (21) ◽  
pp. 3760-3769 ◽  
Author(s):  
Ning Li ◽  
Chunhua Guo ◽  
Zhenyu Duan ◽  
Lingzhu Yu ◽  
Kui Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Matrix Metalloproteinase ◽  
Drug Delivery System ◽  
Delivery System ◽  
Matrix Metalloproteinase 2 ◽  
Stimuli Responsive ◽  
Delivery Vehicle ◽  
Breast Cancer Therapy

A Janus mPEGylated dendron–PVGLIG–DOX conjugate self-assembled into nanoparticles was employed as a matrix metalloproteinase-2/9 enzyme-sensitive and safe nanoscale drug delivery system for breast cancer therapy.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Halloysite Nanotube ◽  
Anticancer Efficacy

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.

scholarly journals Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Therapy
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