scholarly journals Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles

2015 ◽  
Vol 14 (4) ◽  
pp. 737-747 ◽  
Author(s):  
Girgis Obaid ◽  
Isabelle Chambrier ◽  
Michael J. Cook ◽  
David A. Russell
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Comparative Study ◽  
Targeted Treatment ◽  
Cancer Targeting ◽  
Therapy Efficacy

The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment.

Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity

2015 ◽  
Vol 21 (29) ◽  
pp. 4240-4251 ◽  
Author(s):  
Jun Zhao ◽  
Patrick Lee ◽  
Michael Wallace ◽  
Marites Melancon
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Therapy Efficacy

scholarly journals Comparative Study of Gold Nanoparticles Synthesized via Wet Chemical and Green Chemistry approach

2021 ◽  
Vol 1033 ◽  
pp. 012051
Author(s):  
Sonal Rattan ◽  
Anjali Leal ◽  
Mamta Sharma ◽  
Suresh Kumar ◽  
J K Goswamy
Keyword(s):  
Gold Nanoparticles ◽  
Green Chemistry ◽  
Comparative Study ◽  
Wet Chemical

Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne

2021 ◽  
Author(s):  
Syed Baseeruddin Alvi ◽  
P. S. Rajalakshmi ◽  
Anil Jogdand ◽  
Ambekar Yogeshwari Sanjay ◽  
Veeresh B. ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Localized Delivery

Iontophoresis mediated localized delivery of drug entrapping liposomal gold nanoparticles for photothermal and photodynamic therapy of acne.

Comparative study of imiquimod 3.75% vs. photodynamic therapy for actinic keratosis of the scalp

2021 ◽  
Author(s):  
Chiara Cortelazzi ◽  
Giulia Odorici ◽  
Elisa Castagnetti ◽  
Giovanni Pellacani ◽  
Sergio Di Nuzzo
Keyword(s):  
Photodynamic Therapy ◽  
Comparative Study ◽  
Actinic Keratosis

Evaluation of photodynamic therapy efficiency using an in vitro three-dimensional microfluidic breast cancer tissue model

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 735-744 ◽  
Author(s):  
Yamin Yang ◽  
Xiaochuan Yang ◽  
Jin Zou ◽  
Chao Jia ◽  
Yue Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Three Dimensional ◽  
Therapeutic Agents ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Tissue Model

A microfluidic-based in vitro three-dimensional (3D) breast cancer tissue model was established for determining the efficiency of photodynamic therapy (PDT) with therapeutic agents (photosensitizer and gold nanoparticles) under various irradiation conditions.

Current phthalocyanines delivery systems in photodynamic therapy: an updated review

2021 ◽  
Vol 28 ◽  
Author(s):  
Mariana Miretti ◽  
Cesar German Prucca ◽  
Tomas Cristian Tempesti ◽  
Maria Teresa Baumgartner
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Current Status ◽  
Oxygen Species ◽  
Cancer Treatments ◽  
Therapy Efficacy ◽  
Cellular Components

: Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer with light in the presence of oxygen to generate reactive oxygen species capable of reacting with cellular components resulting in injury and, consequently, inducing cellular death. Phthalocyanines are considered good photosensitizers, although most of them are lipophilic, difficulting their administration for clinical use. A strategy to overcome the lack of solubility of phthalocyanines in aqueous media is to incorporate them into different delivery systems. The present review aimed to summarize the current status of the main drug delivery systems used for Zn and Al phthalocyanines and their effect in photodynamic therapy, reported in the last five years. Liposomes, polymeric micelles, polymeric nanoparticles, and gold-nanoparticles constituted some of the most used carriers and were discussed in this review. The latest studies reported strongly suggests that the application of nanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy and reduce side-effects associated with the phthalocyanine administration, which represents a promise for cancer treatments.

Sign in / Sign up

Export Citation Format

Share Document