Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel–Crafts type allylic alkylation of phenols

2015 ◽  
Vol 13 (10) ◽  
pp. 3086-3092 ◽  
Author(s):  
Zheng-Le Zhao ◽  
Qing-Long Xu ◽  
Qing Gu ◽  
Xin-Yan Wu ◽  
Shu-Li You
Keyword(s):  
Enantioselective Synthesis ◽  
Alkylation Reaction ◽  
Allylic Alkylation ◽  
Palladium Catalyzed

Pd-catalyzed asymmetric intramolecular allylic alkylation reaction of phenols was developed, affording C4 substituted tetrahydroisoquinolines in moderate to excellent yields, enantioselectivity and regioselectivity.

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

scholarly journals Palladium-Catalyzed Asymmetric Allylic Alkylation Reaction of 2-Mono­substituted Indolin-3-ones

Synthesis ◽  
2014 ◽  
Vol 47 (01) ◽  
pp. 134-140 ◽  
Author(s):  
Xue-Long Hou ◽  
Tie-Gen Chen ◽  
Ping Fang ◽  
Li-Xin Dai
Keyword(s):  
Alkylation Reaction ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed

Multifunctional chiral aminophosphines for enantiodivergent catalysis in a palladium‐catalyzed allylic alkylation reaction

Chirality ◽  
2020 ◽  
Vol 32 (11) ◽  
pp. 1311-1323
Author(s):  
Sviatoslav S. Eliseenko ◽  
Mohan Bhadbhade ◽  
Fei Liu
Keyword(s):  
Alkylation Reaction ◽  
Allylic Alkylation ◽  
Palladium Catalyzed
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