Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement

2015 ◽  
Vol 13 (9) ◽  
pp. 2664-2668 ◽  
Author(s):  
Christopher A. P. Whittaker ◽  
Simon G. Patching ◽  
Mikael Esmann ◽  
David A. Middleton
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Receptor Site ◽  
Paramagnetic Relaxation ◽  
Paramagnetic Relaxation Enhancement ◽  
Inverted Orientation ◽  
Inhibitory Site ◽  
Ligand Orientation

Paramagnetic relaxation-enhanced solid-state NMR reveals a ouabain analogue with an inverted orientation in the Na,K-ATPase inhibitory site.

scholarly journals Solid-State NMR 31P Paramagnetic Relaxation Enhancement Membrane Protein Immersion Depth Measurements

2014 ◽  
Vol 118 (16) ◽  
pp. 4370-4377 ◽  
Author(s):  
Sergey Maltsev ◽  
Stephen M. Hudson ◽  
Indra D. Sahu ◽  
Lishan Liu ◽  
Gary A. Lorigan
Keyword(s):  
Solid State ◽  
Membrane Protein ◽  
Solid State Nmr ◽  
Paramagnetic Relaxation ◽  
Immersion Depth ◽  
Paramagnetic Relaxation Enhancement

scholarly journals Characterization of Protein–Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements

2017 ◽  
Vol 139 (35) ◽  
pp. 12165-12174 ◽  
Author(s):  
Carl Öster ◽  
Simone Kosol ◽  
Christoph Hartlmüller ◽  
Jonathan M. Lamley ◽  
Dinu Iuga ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Paramagnetic Relaxation ◽  
Protein Interfaces ◽  
Paramagnetic Relaxation Enhancements
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