Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement

2015 ◽  
Vol 13 (5) ◽  
pp. 1463-1469 ◽  
Author(s):  
Aaron Johnson ◽  
Matthew J. Saunders ◽  
Thomas G. Back
Keyword(s):  
Quaternary Amine ◽  
Porcine Liver ◽  
Curtius Rearrangement ◽  
Liver Esterase ◽  
Enzymatic Desymmetrization ◽  
Porcine Liver Esterase

BIRT-377 was synthesized by enzymatic desymmetrization in conjunction with Curtius rearrangement, affording a key α-quaternary amine intermediate in high ee.

Biocatalytical Transformations, III [1] Regioselective Enzymic Deacetylations of Laevoglucosane Triacetate

1988 ◽  
Vol 43 (10) ◽  
pp. 1355-1357 ◽  
Author(s):  
René Csuk ◽  
Brigitte I Glänzer
Keyword(s):  
Wheat Germ ◽  
Hydrolytic Enzymes ◽  
Type I ◽  
Porcine Liver ◽  
Liver Esterase ◽  
Rhizopus Javanicus ◽  
Porcine Liver Esterase

Abstract Several hydrolytic enzymes (porcine liver esterase, lipase from wheat germ type I, and the lipase from rhizopus javanicus) efficiently deacetylate laevoglucosane triacetate (2) with good regioselectivity into diacetylated laevoglucosane derivatives (3-5).

Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase

2018 ◽  
Vol 47 ◽  
pp. 178-185 ◽  
Author(s):  
Christine Höllerer ◽  
Günther Becker ◽  
Thomas Göen ◽  
Elisabeth Eckert
Keyword(s):  
Porcine Liver ◽  
Liver Esterase ◽  
Porcine Liver Esterase

Spectrophotometric Assay for Porcine Liver Esterase Activity

1995 ◽  
Vol 231 (1) ◽  
pp. 265-267 ◽  
Author(s):  
J. Zhou ◽  
R.J. Ain ◽  
C.M. Riley ◽  
R.L. Schowen
Keyword(s):  
Esterase Activity ◽  
Spectrophotometric Assay ◽  
Porcine Liver ◽  
Liver Esterase ◽  
Porcine Liver Esterase
Sign in / Sign up

Export Citation Format

Share Document