Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

2015 ◽  
Vol 13 (2) ◽  
pp. 409-423 ◽  
Author(s):  
Laurent Le Corre ◽  
Lotfi Tak-Tak ◽  
Arthur Guillard ◽  
Guillaume Prestat ◽  
Christine Gravier-Pelletier ◽  
...  
Keyword(s):  
Building Blocks ◽  
Diversity Oriented Synthesis ◽  
Microwave Assisted

The obtention of 4-amino-3-cyano-N-arylpyrazoles via a μW mediated cyclization allowed the diversity oriented syntheses of various heteroyclic scaffolds.

ChemInform Abstract: Microwave-Assisted Preparation of 4-Amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as Building Blocks for the Diversity-Oriented Synthesis of Pyrazole-Based Polycyclic Scaffolds.

ChemInform ◽  
2015 ◽  
Vol 46 (21) ◽  
pp. no-no
Author(s):  
Laurent Le Corre ◽  
Lotfi Tak-Tak ◽  
Arthur Guillard ◽  
Guillaume Prestat ◽  
Christine Gravier-Pelletier ◽  
...  
Keyword(s):  
Building Blocks ◽  
Diversity Oriented Synthesis ◽  
Microwave Assisted

Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction

2010 ◽  
Vol 12 (12) ◽  
pp. 2774-2777 ◽  
Author(s):  
Jitender B. Bariwal ◽  
Denis S. Ermolat’ev ◽  
Toma N. Glasnov ◽  
Kristof Van Hecke ◽  
Vaibhav P. Mehta ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Diversity Oriented Synthesis ◽  
Microwave Assisted ◽  
A3 Coupling

Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks

2016 ◽  
Vol 2017 (3) ◽  
pp. 469-475 ◽  
Author(s):  
Reuben Ovadia ◽  
Clémence Mondielli ◽  
Jean-Jacques Vasseur ◽  
Carine Baraguey ◽  
Karine Alvarez
Keyword(s):  
Building Blocks ◽  
Ugi Reaction ◽  
One Pot ◽  
Microwave Assisted

scholarly journals Microwave Assisted Reactions of Fluorescent Pyrrolodiazine Building Blocks

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3760
Author(s):  
Costel Moldoveanu ◽  
Dorina Amariucai-Mantu ◽  
Violeta Mangalagiu ◽  
Vasilichia Antoci ◽  
Dan Maftei ◽  
...  
Keyword(s):  
Spectral Properties ◽  
Building Blocks ◽  
Biological Molecules ◽  
Quantum Yields ◽  
Dipolar Cycloaddition ◽  
Dimethyl Acetylenedicarboxylate ◽  
Microwave Assisted ◽  
Subsequent Step ◽  
Blue Emitters ◽  
Mw Irradiation

We report here the synthesis and optical spectral properties of several new pyrrolodiazine derivatives. The luminescent heterocycles were synthesized by 1,3-dipolar cycloaddition reactions between N-alkylated pyridazine and methylpropiolate or dimethyl acetylenedicarboxylate (DMAD). The pyrrolopyridazine derivatives are blue emitters with moderate quantum yields (around 25%) in the case of pyrrolopyridazines and negligible yet measurable emission for pyrrolophthalazines. In a subsequent step towards including the pyrrolodiazine moiety, given its spectral properties in various macromolecular frameworks such as biological molecules, a subset of the synthetized compounds has been subjected to α-bromination. A selective and efficient way for α-bromination in heterogeneous catalysis of pyrrolodiazine derivatives under microwave (MW) irradiation is presented. We report substantially higher yields under MW irradiation, whereas the solvent amounts required are at least five-fold less compared to classical heating.

ChemInform Abstract: Efficient Ytterbium Triflate Catalyzed Microwave-Assisted Synthesis of 3-Acylacrylic Acid Building Blocks.

ChemInform ◽  
2009 ◽  
Vol 40 (13) ◽  
Author(s):  
Nikita V. Tolstoluzhsky ◽  
Nikolay Yu. Gorobets ◽  
Nadezhda N. Kolos ◽  
Sergey M. Desenko
Keyword(s):  
Building Blocks ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Ytterbium Triflate

Microwave Assisted Synthesis of N-(ethoxycarbonylmethyl)-nucleobases: Building Blocks for PNAs

2005 ◽  
Vol 2005 (3) ◽  
pp. 167-168 ◽  
Author(s):  
Gui-Rong Qu ◽  
Yong Li ◽  
Su-Hui Han
Keyword(s):  
Microwave Irradiation ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Building Blocks ◽  
Microwave Assisted Synthesis ◽  
Ethyl Bromoacetate ◽  
Microwave Assisted

The synthesis of N1/N9- (Ethoxycarbonylmethyl)pyrimidine/purine using as synthons for peptide nucleic acids has been described. Microwave irradiation provided the desired products by alkylation of the appropriately protected natural and substituted nucleobases with ethyl bromoacetate within 4–7 min in 48–85% yields.

Microwave-Assisted Cyclization of Unprotected Dipeptides in Water to 2,5-Piperazinediones and Self-Assembly Study of Products­ and Reagents

Synthesis ◽  
2019 ◽  
Vol 51 (14) ◽  
pp. 2829-2838 ◽  
Author(s):  
Marina Kurbasic ◽  
Sabrina Semeraro ◽  
Ana M. Garcia ◽  
Slavko Kralj ◽  
Evelina Parisi ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Single Crystal ◽  
Self Assembly ◽  
Building Blocks ◽  
Single Crystal Xrd ◽  
Microwave Assisted ◽  
Neutral Ph ◽  
High Yields

Dipeptides and their cyclized 2,5-piperazinedione (or diketopiperazine, DKP) derivatives are attractive building blocks for supra­molecular hydrogels. The Phe-Phe, (p-nitro)-Phe-Phe, and Phe-Val dipeptides and their corresponding DKPs are studied for self-assembly in water. The DKPs were obtained in high yields by microwave-assisted cyclization­ of the dipeptides in water, demonstrating that use of their methyl ester derivatives as reported in the literature is not necessary for successful cyclization. Single-crystal XRD structures are reported for two DKPs as well as stable hydrogels at neutral pH.

scholarly journals Exploring chemical diversity via a modular reaction pairing strategy

2012 ◽  
Vol 8 ◽  
pp. 1293-1302 ◽  
Author(s):  
Joanna K Loh ◽  
Sun Young Yoon ◽  
Thiwanka B Samarakoon ◽  
Alan Rolfe ◽  
Patrick Porubsky ◽  
...  
Keyword(s):  
Amino Alcohol ◽  
Building Blocks ◽  
Chemical Diversity ◽  
Nucleophilic Aromatic Substitution ◽  
Mitsunobu Reaction ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Microwave Assisted ◽  
Computational Analyses ◽  
Pairing Protocol

The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generated by means of a sulfonylation/SNAr/Mitsunobu reaction pairing protocol, and subsequently diversified by intermolecular SNAr with ten chiral, non-racemic amine/amino alcohol building blocks. Computational analyses were employed to explore and evaluate the chemical diversity of the library.

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