The protecting-group directed diastereoselective Nozaki–Hiyama–Kishi (NHK) reaction: total synthesis and biological evaluation of zeaenol, 7-epi-zeaenol and its analogues

2014 ◽  
Vol 12 (47) ◽  
pp. 9683-9695 ◽  
Author(s):  
Debendra K. Mohapatra ◽  
D. Sai Reddy ◽  
N. Arjunreddy Mallampudi ◽  
Janardhan Gaddam ◽  
Sowjanya Polepalli ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Synthesis And Biological Evaluation

A convergent and concise total synthesis of zeaenol, 7-epi-zeaenol, and its analogues is achieved using protecting group-directed NHK reaction.

Protecting-Group-Free Total Synthesis and Biological Evaluation of 3-Methylkealiiquinone and Structural Analogues

2018 ◽  
Vol 83 (17) ◽  
pp. 10627-10635 ◽  
Author(s):  
Velayudham Ramadoss ◽  
Angel Josabad Alonso-Castro ◽  
Nimsi Campos-Xolalpa ◽  
César R. Solorio-Alvarado
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Structural Analogues ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: The Protecting-Group Directed Diastereoselective Nozaki-Hiyama-Kishi (NHK) Reaction: Total Synthesis and Biological Evaluation of Zeaenol (I), 7-epi-Zeaenol (II) and Its Analogues.

ChemInform ◽  
2015 ◽  
Vol 46 (18) ◽  
pp. no-no
Author(s):  
Debendra K. Mohapatra ◽  
D. Sai Reddy ◽  
N. Arjunreddy Mallampudi ◽  
Janardhan Gaddam ◽  
Sowjanya Polepalli ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Synthesis And Biological Evaluation

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

Total synthesis and biological evaluation of Wewakazole

2017 ◽  
Vol 33 (6) ◽  
pp. 890-894 ◽  
Author(s):  
Bohua Long ◽  
Jingzhao Zhang ◽  
Xueyan Wang ◽  
Xudong Tang ◽  
Zhengzhi Wu
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof

2009 ◽  
Vol 131 (30) ◽  
pp. 10587-10597 ◽  
Author(s):  
K. C. Nicolaou ◽  
Xiao-Shui Peng ◽  
Ya-Ping Sun ◽  
Damien Polet ◽  
Bin Zou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

2018 ◽  
Vol 57 (34) ◽  
pp. 11020-11024 ◽  
Author(s):  
Hiromu Hattori ◽  
Joel Roesslein ◽  
Patrick Caspers ◽  
Katja Zerbe ◽  
Hideki Miyatake-Ondozabal ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Macrocyclic Antibiotic ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues

2009 ◽  
Vol 15 (46) ◽  
pp. 12807-12818 ◽  
Author(s):  
Haruhiko Fuwa ◽  
Asami Saito ◽  
Shinya Naito ◽  
Keiichi Konoki ◽  
Mari Yotsu-Yamashita ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation

2020 ◽  
Author(s):  
Andrea Dorst ◽  
Regina Berg ◽  
Christoph Gertzen ◽  
Daniel Schäfle ◽  
katja zerbe ◽  
...  
Keyword(s):  
Structural Design ◽  
Water Solubility ◽  
Biological Evaluation ◽  
Protecting Group ◽  
Design Synthesis ◽  
Gram Positive Bacteria ◽  
Excellent Activity ◽  
One Step ◽  
Hybrid Antibiotics ◽  
Synthesis And Biological Evaluation

<p>The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Main limitations of the compound include low water solubility, which impacts further clinical use. We report on the synthesis of new fidaxomicin derivatives based on structural design and utilizing an operationally simple one-step protecting group-free preparative approach from the natural product. An increase in solubility of up to 25-fold with largely retained activity was observed. Furthermore, hybrid antibiotics were prepared that show improved antibiotic activities</p>

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