Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

2014 ◽  
Vol 12 (27) ◽  
pp. 4885-4889 ◽  
Author(s):  
Jiaxing Hu ◽  
Zhihong Deng ◽  
Xueqiong Zhang ◽  
Fanglin Zhang ◽  
Hua Zheng
Keyword(s):  
Synthetic Route ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Three Component Reaction

A convenient one-pot synthesis of polysubstituted benzofuro[2,3-c]pyridines by three-component is developed. It provides a flexible and rapid synthetic route for the construction of benzofuro[2,3-c]pyridines under mild and metal-free reaction conditions in moderate to good yields (up to 83%).

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Metal free one-pot synthesis of α-ketoamides from terminal alkenes

RSC Advances ◽  
2015 ◽  
Vol 5 (58) ◽  
pp. 47265-47269 ◽  
Author(s):  
Sayan Dutta ◽  
Surya Srinivas Kotha ◽  
Govindasamy Sekar
Keyword(s):  
Practical Approach ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Terminal Alkenes

A practical approach towards the synthesis of α-ketoamides from terminal alkenes has been developed using I2/IBX under one-pot reaction conditions.

scholarly journals Pentafluoropropionic Acid: An Efficient and Metal-Free Catalyst for the One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Naser Montazeri ◽  
Taghva Noghani ◽  
Mona Ghorchibeigy ◽  
Rozita Zoghi
Keyword(s):  
Reaction Time ◽  
Aromatic Aldehyde ◽  
One Pot ◽  
Short Reaction Time ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
High Yields

Pentafluoropropionic acid (PFPA) efficiently catalyzes the one-pot, three-component reaction of aromatic aldehyde, malononitrile, and dimedone to yield tetrahydrobenzo[b]pyran derivatives in high yields. This method is of great value because of its easy processing, short reaction time, environmentally, and high yields.

A New Protocol for Total Synthesis of Natural Product Frutinone A and Its Derivatives

2016 ◽  
Vol 69 (1) ◽  
pp. 98 ◽  
Author(s):  
Kang Lei ◽  
Dong-Wei Sun ◽  
Yuan-Yuan Tao ◽  
Xiao-Hua Xu
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Good Yield ◽  
Substitution Reaction ◽  
High Tolerance ◽  
Synthetic Route ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Intramolecular Nucleophilic Substitution

A new protocol for total synthesis of natural product frutinone A was accomplished in three steps by using inexpensive 2′-hydroxyacetophenone as starting material. The key intermediate 3-(2-chlorobenzoyl)-4-hydroxycoumarin was synthesized in one pot through Baker–Venkataraman rearrangement of 2-acetylphenyl 2-chlorobenzoate followed by introduction of methyl chloroformate under basic conditions. Then, base-promoted intramolecular nucleophilic substitution reaction of 3-(2-chlorobenzoyl)-4-hydroxycoumarin provided frutinone A in excellent yield. The synthetic route features good yield, transition metal-free and mild reaction conditions, and high tolerance for functionality, thereby allowing easy substitutions around the frutinone A core.

CuO Nanoparticles: A Mild and Efficient Reusable Catalyst for the One-Pot Synthesis of 4-amino-5-pyrimidinecarbonitriles under Aqueous Conditions

2012 ◽  
Vol 326-328 ◽  
pp. 372-376
Author(s):  
Seyed Javad Ahmadi ◽  
Sodeh Sadjadi ◽  
Morteza Hosseinpour
Keyword(s):  
Efficient Method ◽  
Reaction Times ◽  
Cuo Nanoparticles ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
Aqueous Conditions

An efficient method for the synthesis of 4-amino-5-pyrimidinecarbonitriles by three-component reaction of malononitrile, aldehydes and N-unsubstituted amidines, under aqueous conditions, using CuO nanoparticles as catalyst is reported. The protocol offers advantages in terms of higher yields, short reaction times, and mild reaction conditions, with reusability of the catalyst.

scholarly journals Convenient one-pot synthesis of 1,2,4-oxadiazoles and 2,4,6-triarylpyridines using graphene oxide (GO) as a metal-free catalyst: importance of dual catalytic activity

RSC Advances ◽  
2021 ◽  
Vol 11 (51) ◽  
pp. 32106-32118
Author(s):  
Puja Basak ◽  
Sourav Dey ◽  
Pranab Ghosh
Keyword(s):  
Graphene Oxide ◽  
Catalytic Activity ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

Graphene oxide (GO) as a metal-free catalyst for the synthesis of 1,2,4-oxadiazoles and 2,4,6-triarylpyridines under mild reaction conditions.

Two Efficient One-Pot Approaches for Regioselective Synthesis of New 3-Arylpyridazino[4,3-c]quinolin-5(6H)-ones

2015 ◽  
Vol 68 (10) ◽  
pp. 1529 ◽  
Author(s):  
Mehdi Rimaz
Keyword(s):  
Hydrazine Hydrate ◽  
Regioselective Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Arylglyoxal Monohydrates ◽  
Operational Simplicity

Two efficient regioselective approaches for the one-pot synthesis of 3-arylpyridazino[4,3-c]quinolin-5(6H)-one derivatives are reported, by the three-component reaction of arylglyoxal monohydrates, quinoline-2,4-diol, and hydrazinium dihydrochloride or hydrazine hydrate in ethanol and pyridine. In ethanol, the reactions were catalyzed by 1,4-diazobicyclo[2,2,2]octane. The features of both procedures are high regioselectivity, mild reaction conditions, good to high yields, and operational simplicity.

scholarly journals “In Situ” Generated “HCl”: A Highly Efficient Catalyst for One-Pot Synthesis of 1H-Indazolo [1,2-b]phthalazine-1,6,11-triones and 1Hpyrazolo[1,2-b]phthalazine-5,10-diones under Solvent-Free Conditions

2017 ◽  
Vol 58 (2) ◽  
Author(s):  
Behrooz Maleki ◽  
Samaneh Sedigh Ashrafi
Keyword(s):  
Phthalic Anhydride ◽  
Solvent Free ◽  
Synthetic Route ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

<p>The rapid and environmental synthetic route to produce 1<em>H</em>-indazolo[1,2-b] phthalazine-1,6,11-triones and 1<em>H</em>-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives have been developed <em>via</em> multicomponent and one-pot reactions of various aldehydes, cyclic or acyclic 1,3-diketones with: <em>i)</em> phthalhydrazide or <em>ii)</em> phthalic anhydride-hydrazinium hydroxide using wet 2,4,6-trichlorotriazine (TCT) as catalyst under solvent-free conditions. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.</p>

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