Recent advances in catalytic C–N bond formation: a comparison of cascade hydroaminomethylation and reductive amination reactions with the corresponding hydroamidomethylation and reductive amidation reactions

2014 ◽  
Vol 12 (37) ◽  
pp. 7179 ◽  
Author(s):  
Saeed Raoufmoghaddam
Keyword(s):  
Reductive Amination ◽  
Bond Formation ◽  
Recent Advances

Recent Advances on C-Se Bond-forming Reactions at Low and Room Temperature

2020 ◽  
Vol 23 (28) ◽  
pp. 3206-3225 ◽  
Author(s):  
Amol D. Sonawane ◽  
Mamoru Koketsu
Keyword(s):  
Room Temperature ◽  
Bond Formation ◽  
Bond Forming ◽  
Material Chemistry ◽  
Recent Advances ◽  
Bond Forming Reactions ◽  
Bond Formation Reactions

: Over the last decades, many methods have been reported for the synthesis of selenium- heterocyclic scaffolds because of their interesting reactivities and applications in the medicinal as well as in the material chemistry. This review describes the recent numerous useful methodologies on C-Se bond formation reactions which were basically carried out at low and room temperature.

Recent Advances in Reductive Amination Catalysis and Its Applications

2015 ◽  
Vol 19 (11) ◽  
pp. 1021-1049 ◽  
Author(s):  
Heshmatollah Alinezhad ◽  
Hossein Yavari ◽  
Fatemeh Salehian
Keyword(s):  
Reductive Amination ◽  
Recent Advances

scholarly journals C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2040
Author(s):  
Zsolt Fülöp ◽  
Péter Bana ◽  
István Greiner ◽  
János Éles
Keyword(s):  
Antipsychotic Drug ◽  
Catalytic Hydrogenation ◽  
Continuous Flow ◽  
Reductive Amination ◽  
Reduction Method ◽  
Bond Formation ◽  
Aluminum Salt ◽  
Line Extraction ◽  
Piperazine Derivative ◽  
Step Procedure

A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug cariprazine. The two-step procedure consists of a DIBAL-H mediated selective ester reduction conducted in a novel, miniature alternating diameter reactor, followed by reductive amination using catalytic hydrogenation on 5% Pt/C. The connection of the optimized modules was accomplished using an at-line extraction to prevent precipitation of the aluminum salt byproducts.

Recent Advances in C–Br Bond Formation

Synlett ◽  
2021 ◽  
Author(s):  
Ying-Yeung Yeung ◽  
Jonathan Wong
Keyword(s):  
Organic Synthesis ◽  
Aromatic Compounds ◽  
Bond Formation ◽  
Cross Coupling ◽  
Catalytic Site ◽  
Atom Transfer ◽  
Bond Forming ◽  
Recent Advances ◽  
Catalytic Asymmetric ◽  
Site Selective

AbstractOrganobromine compounds are extremely useful in organic synthesis. In this perspective, a focused discussion on some recent advancements in C–Br bond-forming reactions is presented.1 Introduction2 Selected Recent Advances2.1 Catalytic Asymmetric Bromopolycyclization of Olefinic Substrates2.2 Catalytic Asymmetric Intermolecular Bromination2.3 Some New Catalysts and Reagents for Bromination2.4 Catalytic Site-Selective Bromination of Aromatic Compounds2.5 sp3 C–H Bromination via Atom Transfer/Cross-Coupling3 Outlook

Recent advances in Co-catalyzed C–C and C–N bond formation via ADC and ATH reactions

Tetrahedron ◽  
2021 ◽  
pp. 132309
Author(s):  
Meng-Juan Zhang ◽  
Xiao-Lan Ge ◽  
David J. Young ◽  
Hong-Xi Li
Keyword(s):  
Bond Formation ◽  
Recent Advances

ChemInform Abstract: Recent Advances in Aryl—Aryl Bond Formation by Direct Arylation

ChemInform ◽  
2009 ◽  
Vol 40 (49) ◽  
Author(s):  
Gerard P. McGlacken ◽  
Lorraine M. Bateman
Keyword(s):  
Bond Formation ◽  
Direct Arylation ◽  
Recent Advances

ChemInform Abstract: Recent Advances in C-H Bond Formation in Aqueous Media: A Mechanistic Perspective

ChemInform ◽  
2008 ◽  
Vol 39 (23) ◽  
Author(s):  
V. Tamara Perchyonok ◽  
Ioannis N. Lykakis ◽  
Kellie L. Tuck
Keyword(s):  
Bond Formation ◽  
Aqueous Media ◽  
Recent Advances

Recent advances in radical-based C–N bond formation via photo-/electrochemistry

2018 ◽  
Vol 47 (8) ◽  
pp. 2591-2608 ◽  
Author(s):  
Yating Zhao ◽  
Wujiong Xia
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Recent Advances

This review highlights the recent advances in cross-dehydrogenative amination for C–N bond construction from C–H/N–H cross-coupling partners through photocatalytic and/or electronic techniques.

Metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions

2019 ◽  
Vol 6 (13) ◽  
pp. 2183-2199 ◽  
Author(s):  
Shengqing Ye ◽  
Tianyi Xiang ◽  
Xiaofang Li ◽  
Jie Wu
Keyword(s):  
Functional Group ◽  
Bond Formation ◽  
Alkyl Halides ◽  
Type Transformation ◽  
Recent Advances ◽  
Metal Catalyzed ◽  
Radical Type

Recent advances in the metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions are summarized. Usually, a broad reaction scope is observed including tertiary, secondary, and primary alkyl halides, with good functional group compatibility.

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