Carbohydrate-based first stereoselective total synthesis of bioactive cytospolide P

2014 ◽  
Vol 12 (21) ◽  
pp. 3358-3361 ◽  
Author(s):  
Pathi Suman ◽  
Bhimapaka China Raju
Keyword(s):  
Total Synthesis ◽  
Yamaguchi Macrolactonization

A facile stereoselective approach has been developed for the total synthesis of cytospolide P via Yamaguchi macrolactonization.

An enantioselective total synthesis of Sch-725674

2015 ◽  
Vol 13 (1) ◽  
pp. 234-240 ◽  
Author(s):  
Kota Ramakrishna ◽  
Krishna P. Kaliappan
Keyword(s):  
Total Synthesis ◽  
Metathesis Reaction ◽  
Stereoselective Reduction ◽  
Enantioselective Total Synthesis ◽  
Cross Metathesis ◽  
Yamaguchi Macrolactonization ◽  
Key Steps

An enantioselective total synthesis of Sch-725674 using dithiane alkylation, cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction as key steps is described.

scholarly journals A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

2012 ◽  
Vol 8 ◽  
pp. 1344-1351 ◽  
Author(s):  
James R Cochrane ◽  
Dong Hee Yoon ◽  
Christopher S P McErlean ◽  
Katrina A Jolliffe
Keyword(s):  
Antifungal Activity ◽  
Total Synthesis ◽  
Cyclic Peptide ◽  
Alternative Methods ◽  
Terminal Amino Acid ◽  
Cyclic Depsipeptide ◽  
Naturally Occurring ◽  
Yamaguchi Macrolactonization ◽  
Terminal Amino ◽  
Peptide Core

The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach. Alternative methods of macrolactonization (e.g., Corey–Nicolaou) resulted in significant epimerization of the C-terminal amino acid during the cyclization reaction. The D-stereochemistry of the alanine residue in the naturally occurring cyclic peptide may be required for the antifungal activity of this natural product.

Total synthesis of (−)-(6R,11R,14S)-colletallol via proline catalyzed α-aminoxylation and Yamaguchi macrolactonization

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63607-63612 ◽  
Author(s):  
Shruti Vandana Kauloorkar ◽  
Pradeep Kumar
Keyword(s):  
Total Synthesis ◽  
Efficient Synthesis ◽  
Yamaguchi Macrolactonization

A simple and efficient synthesis of 14-membered macrolide (−)-(6R,11R,14S)-colletallol was achieved in a highly diastereoselective manner using proline catalyzed alpha-aminoxylation and Yamaguchi protocol.

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product
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