scholarly journals Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (17) ◽  
pp. 7885-7895 ◽  
Author(s):  
Hui Wang ◽  
Guixin Cao ◽  
Zheng Gai ◽  
Kunlun Hong ◽  
Probal Banerjee ◽  
...  
Keyword(s):  
Drug Release ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Hybrid Nanoparticles ◽  
Fluorescent Carbon

Multifunctional hybrid nanoparticles have been developed for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy.

scholarly journals Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Zhou ◽  
Xiaodong Zeng ◽  
Anguo Li ◽  
Wenyi Zhou ◽  
Lin Tang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Great Promise ◽  
Osteosarcoma Cells ◽  
Image Guided ◽  
Donor Acceptor ◽  
Subcellular Resolution

AbstractNIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

Multifunctional Au@mSiO2/Rhodamine B Isothiocyanate Nanocomposites: Cell Imaging, Photocontrolled Drug Release, and Photothermal Therapy for Cancer Cells

Small ◽  
2012 ◽  
Vol 9 (4) ◽  
pp. 604-612 ◽  
Author(s):  
Zhenlong Jiang ◽  
Biao Dong ◽  
Boting Chen ◽  
Jing Wang ◽  
Lin Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Rhodamine B ◽  
Photothermal Therapy ◽  
Cell Imaging ◽  
Rhodamine B Isothiocyanate

Functionalized Bacterial Cellulose Microparticles for Drug Delivery in Biomedical Applications

2019 ◽  
Vol 25 (34) ◽  
pp. 3692-3701 ◽  
Author(s):  
Hanif Ullah ◽  
Munair Badshah ◽  
Alexandra Correia ◽  
Fazli Wahid ◽  
Hélder A. Santos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Drug Release ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Amorphous State ◽  
Spherical Shape

Background: Bacterial cellulose (BC) has recently attained greater interest in various research fields, including drug delivery for biomedical applications. BC has been studied in the field of drug delivery, such as tablet coating, controlled release systems and prodrug design. Objective: In the current work, we tested the feasibility of BC as a drug carrier in microparticulate form for potential pharmaceutical and biomedical applications. Method : For this purpose, drug-loaded BC microparticles were prepared by simple grinding and injection moulding method through regeneration. Model drugs, i.e., cloxacillin (CLX) and cefuroxime (CEF) sodium salts were loaded in these microparticles to assess their drug loading and release properties. The prepared microparticles were evaluated in terms of particle shapes, drug loading efficiency, physical state of the loaded drug, drug release behaviour and antibacterial properties. Results: The BC microparticles were converted to partially amorphous state after regeneration. Moreover, the loaded drug was transformed into the amorphous state. The results of scanning electron microscopy (SEM) showed that microparticles had almost spherical shape with a size of ca. 350-400 μm. The microparticles treated with higher drug concentration (3%) exhibited higher drug loading. Keeping drug concertation constant, i.e., 1%, the regenerated BC (RBC) microparticles showed higher drug loading (i.e., 37.57±0.22% for CEF and 33.36±3.03% for CLX) as compared to as-synthesized BC (ABC) microparticles (i.e., 9.46±1.30% for CEF and 9.84±1.26% for CLX). All formulations showed immediate drug release, wherein more than 85% drug was released in the initial 30 min. Moreover, such microparticles exhibited good antibacterial activity with larger zones of inhibition for drug loaded RBC microparticles as compared to corresponding ABC microparticles. Conclusion : Drug loaded BC microparticles with immediate release behaviour and antibacterial activity were fabricated. Such functionalized microparticles may find potential biomedical and pharmaceutical applications.

scholarly journals Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications

2017 ◽  
Author(s):  
Hai Feng Zeng ◽  
Mu Yang Sun ◽  
Su Fan Wu ◽  
Hai Feng Chen
Keyword(s):  
Crystal Structure ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Drug Carrier ◽  
Great Promise ◽  
Drug Molecules ◽  
Model Drug ◽  
New Feature ◽  
A375 Cells

Europium (Eu)-doped fluorapatite (FA) nanorods has a similar biocompatibility with hydroxyapatite (HA) in terms, attracted much attention as cell imaging biomaterials due to their luminescent property. Here, we will discuss the new feature of europium doped fluorapatite (Eu-FA) nanorods as anticancer drug carrier. Eu-FA nanorods was prepared using a hydrothermal method. The morphology, crystal structure, fluorescence and composition are investigated. The specific crystal structure, enabling an effective loading of drug molecules. Doxorubicin (DOX), used as an anticancer model drug, was shown to be effectively loaded onto the surface of the nanorods. The DOX release was fairly pH-dependent, occurring more rapidly at pH 5.5 than pH 7.4 was observed. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA show great promise for tracking and treating tumor, may potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs.

Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy

2014 ◽  
Vol 2 (6) ◽  
pp. 915-923 ◽  
Author(s):  
Hui Wang ◽  
Jing Shen ◽  
Yingyu Li ◽  
Zengyan Wei ◽  
Guixin Cao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Drug Carrier ◽  
Hybrid Nanoparticles ◽  
Infrared Light ◽  
Great Promise ◽  
High Efficacy ◽  
Imaging Diagnostics ◽  
Simultaneous Imaging ◽  
Fluorescent Carbon Dots

The multifunctional hybrid nanoparticles described demonstrate great promise towards advanced nanoplatforms for simultaneous imaging diagnostics and high efficacy therapy.

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

scholarly journals Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 906
Author(s):  
Le Minh Tu Phan ◽  
Thuy Anh Thu Vo ◽  
Thi Xoan Hoang ◽  
Sungbo Cho
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
High Light ◽  
Conversion Materials ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Biomedical Field ◽  
Hydrogel Composites ◽  
Material Fabrication ◽  
Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

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