Cell interaction with graphene microsheets: near-orthogonal cutting versus parallel attachment

Nanoscale ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 5457-5467 ◽  
Author(s):  
Xin Yi ◽  
Huajian Gao
Keyword(s):  
Cell Membrane ◽  
Theoretical Study ◽  
Driving Forces ◽  
Orthogonal Cutting ◽  
Cell Interaction ◽  
Membrane Tension ◽  
Modes Of Interaction

A theoretical study has been performed on two fundamental modes of interaction between cell membrane and graphene microsheets: near-perpendicular transmembrane penetration and parallel attachment. The analysis reveals how membrane tension, splay or bending energies contribute to the driving forces in these two interaction modes.

Cell membrane wrapping of a spherical thin elastic shell

Soft Matter ◽  
2015 ◽  
Vol 11 (6) ◽  
pp. 1107-1115 ◽  
Author(s):  
Xin Yi ◽  
Huajian Gao
Keyword(s):  
Cell Membrane ◽  
Detailed Analysis ◽  
Theoretical Study ◽  
Elastic Shell ◽  
Adhesion Energy ◽  
Membrane Tension ◽  
Thin Elastic Shell

A theoretical study on cell membrane wrapping of a spherical thin elastic shell indicates that stiff nanocapsules achieve full wrapping easier than soft ones. The detailed analysis demonstrates how the wrapping degree depends on the size and stiffness of the nanocapsules, adhesion energy and membrane tension.

scholarly journals Cholesterol Depletion by MβCD Enhances Cell Membrane Tension and Its Variations-Reducing Integrity

2019 ◽  
Vol 116 (8) ◽  
pp. 1456-1468 ◽  
Author(s):  
Arikta Biswas ◽  
Purba Kashyap ◽  
Sanchari Datta ◽  
Titas Sengupta ◽  
Bidisha Sinha
Keyword(s):  
Cell Membrane ◽  
Cholesterol Depletion ◽  
Membrane Tension

Mechanics of Curved Plasma Membrane Vesicles: Resting Shapes, Membrane Curvature, and In-Plane Shear Elasticity

2004 ◽  
Vol 127 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Tadashi Kosawada ◽  
Kohji Inoue ◽  
Geert W. Schmid-Schönbein
Keyword(s):  
Plasma Membrane ◽  
Cell Membrane ◽  
Membrane Curvature ◽  
Membrane Tension ◽  
Coated Pits ◽  
Plane Shear ◽  
Plasmalemmal Vesicles ◽  
Cell Functions ◽  
Outer Domain ◽  
Shear Elasticity

Highly curved cell membrane structures, such as plasmalemmal vesicles (caveolae) and clathrin-coated pits, facilitate many cell functions, including the clustering of membrane receptors and transport of specific extracellular macromolecules by endothelial cells. These structures are subject to large mechanical deformations when the plasma membrane is stretched and subject to a change of its curvature. To enhance our understanding of plasmalemmal vesicles we need to improve the understanding of the mechanics in regions of high membrane curvatures. We examine here, theoretically, the shapes of plasmalemmal vesicles assuming that they consist of three membrane domains: an inner domain with high curvature, an outer domain with moderate curvature, and an outermost flat domain, all in the unstressed state. We assume the membrane properties are the same in these domains with membrane bending elasticity as well as in-plane shear elasticity. Special emphasis is placed on the effects of membrane curvature and in-plane shear elasticity on the mechanics of vesicle during unfolding by application of membrane tension. The vesicle shapes were computed by minimization of bending and in-plane shear strain energy. Mechanically stable vesicles were identified with characteristic membrane necks. Upon stretch of the membrane, the vesicle necks disappeared relatively abruptly leading to membrane shapes that consist of curved indentations. While the resting shape of vesicles is predominantly affected by the membrane spontaneous curvatures, the membrane shear elasticity (for a range of values recorded in the red cell membrane) makes a significant contribution as the vesicle is subject to stretch and unfolding. The membrane tension required to unfold the vesicle is sensitive with respect to its shape, especially as the vesicle becomes fully unfolded and approaches a relative flat shape.

A theoretical study of the effects of cyclic AMP phosphodiesterases during aggregation in Dictyostelium

1976 ◽  
Vol 22 (1) ◽  
pp. 49-58 ◽  
Author(s):  
V. Nanjundiah ◽  
D. Malchow
Keyword(s):  
Cyclic Amp ◽  
Cell Membrane ◽  
Theoretical Study ◽  
Enzyme Hydrolysis ◽  
Camp Levels ◽  
Hydrolysis Of

During aggregation the larger Dictyostelium species use cAMP as a chemoattractant and possibly also as a transmitter. In passage from cell to cell, cAMP levels are modulated by diffusion and by enzyme hydrolysis. It appears that the important cAMP-hydrolysing enzyme is a phosphodiesterase bound to the cell membrane, the main roles of which are (1) very fast hydrolysis of cAMP and (2) steepening of spatial cAMP gradients. An extracellular phosphodiesterase has no function, so far as can be conjectured from present data.

scholarly journals Control of cell membrane tension by myosin-I

2009 ◽  
Vol 106 (29) ◽  
pp. 11972-11977 ◽  
Author(s):  
R. Nambiar ◽  
R. E. McConnell ◽  
M. J. Tyska
Keyword(s):  
Cell Membrane ◽  
Membrane Tension ◽  
Myosin I

scholarly journals A Decrease in Membrane Tension Precedes Successful Cell-Membrane Repair

2000 ◽  
Vol 11 (12) ◽  
pp. 4339-4346 ◽  
Author(s):  
Tatsuru Togo ◽  
Tatiana B. Krasieva ◽  
Richard A. Steinhardt
Keyword(s):  
Cell Membrane ◽  
Brefeldin A ◽  
Laser Tweezers ◽  
Membrane Tension ◽  
Membrane Repair ◽  
Ringer’S Solution ◽  
3T3 Fibroblasts ◽  
Membrane Tethers ◽  
Membrane Resealing ◽  
Vesicle Pool

We hypothesized that the requirement for Ca2+-dependent exocytosis in cell-membrane repair is to provide an adequate lowering of membrane tension to permit membrane resealing. We used laser tweezers to form membrane tethers and measured the force of those tethers to estimate the membrane tension of Swiss 3T3 fibroblasts after membrane disruption and during resealing. These measurements show that, for fibroblasts wounded in normal Ca2+ Ringer's solution, the membrane tension decreased dramatically after the wounding and resealing coincided with a decrease of ∼60% of control tether force values. However, the tension did not decrease if cells were wounded in a low Ca2+ Ringer's solution that inhibited both membrane resealing and exocytosis. When cells were wounded twice in normal Ca2+ Ringer's solution, decreases in tension at the second wound were 2.3 times faster than at the first wound, correlating well with twofold faster resealing rates for repeated wounds. The facilitated resealing to a second wound requires a new vesicle pool, which is generated via a protein kinase C (PKC)-dependent and brefeldin A (BFA)-sensitive process. Tension decrease at the second wound was slowed or inhibited by PKC inhibitor or BFA. Lowering membrane tension by cytochalasin D treatment could substitute for exocytosis and could restore membrane resealing in low Ca2+ Ringer's solution.

scholarly journals Nuclear myosin I regulates cell membrane tension

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tomáš Venit ◽  
Alžběta Kalendová ◽  
Martin Petr ◽  
Rastislav Dzijak ◽  
Lukáš Pastorek ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Membrane Tension ◽  
Myosin I ◽  
Nuclear Myosin I
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