pH-responsive biocompatible fluorescent polymer nanoparticles based on phenylboronic acid for intracellular imaging and drug delivery

Nanoscale ◽  
2014 ◽  
Vol 6 (22) ◽  
pp. 13701-13709 ◽  
Author(s):  
Shengliang Li ◽  
Kelei Hu ◽  
Weipeng Cao ◽  
Yun Sun ◽  
Wang Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Phenylboronic Acid ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Intracellular Imaging ◽  
Fluorescent Polymer

Glucose-sensitive polymer nanoparticles for self-regulated drug delivery

2016 ◽  
Vol 52 (49) ◽  
pp. 7633-7652 ◽  
Author(s):  
Li Zhao ◽  
Chunsheng Xiao ◽  
Liyan wang ◽  
Guangqing Gai ◽  
Jianxun Ding
Keyword(s):  
Drug Delivery ◽  
Glucose Oxidase ◽  
Concanavalin A ◽  
Phenylboronic Acid ◽  
Polymer Nanoparticles

Glucose-sensitive polymer nanoparticles based on glucose oxidase, concanavalin A, or phenylboronic acid for self-regulated drug delivery have been reviewed.

scholarly journals Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms

2016 ◽  
Vol 4 (18) ◽  
pp. 3075-3085 ◽  
Author(s):  
Jiayi Zhou ◽  
Benjamin Horev ◽  
Geelsu Hwang ◽  
Marlise I. Klein ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Molecular Weights ◽  
Responsive Polymer ◽  
Oral Biofilms ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Corona and core molecular weights of p(DMAEMA)-b-p(DMAEMA-co-BMA-co-PAA) block copolymer micelles can be tuned to enhance drug release in response to acidic milieus consistent with oral biofilms.

scholarly journals pH‐Responsive Polymer Nanoparticles for Drug Delivery

2019 ◽  
Vol 40 (10) ◽  
pp. 1800917 ◽  
Author(s):  
Nayeleh Deirram ◽  
Changhe Zhang ◽  
Sarah S. Kermaniyan ◽  
Angus P. R. Johnston ◽  
Georgina K. Such
Keyword(s):  
Drug Delivery ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Responsive Polymer

Multifunctional pH-Responsive Folate Receptor Mediated Polymer Nanoparticles for Drug Delivery

2016 ◽  
Vol 12 (7) ◽  
pp. 1453-1462 ◽  
Author(s):  
Xiaoqing Cai ◽  
Xiaoye Yang ◽  
Fang Wang ◽  
Chen Zhang ◽  
Deqing Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folate Receptor ◽  
Polymer Nanoparticles ◽  
Ph Responsive

pH‐Responsive Nanoparticles Loaded with Graphene Quantum Dots and Doxorubicin for Intracellular Imaging, Drug Delivery and Efficient Cancer Therapy

2019 ◽  
Vol 4 (20) ◽  
pp. 6004-6012 ◽  
Author(s):  
Junlong Liang ◽  
Qianwei Huang ◽  
Chenxiang Hua ◽  
Jinhua Hu ◽  
Biling Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Therapy ◽  
Graphene Quantum Dots ◽  
Ph Responsive ◽  
Intracellular Imaging

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

2018 ◽  
Vol 15 (5) ◽  
pp. 652-657 ◽  
Author(s):  
Ramachandran Deepika ◽  
Koyeli Girigoswami ◽  
Ramachandran Murugesan ◽  
Agnishwar Girigoswami
Keyword(s):  
Drug Delivery ◽  
Divalent Cation ◽  
Polymer Nanoparticles ◽  
Delivery Efficiency
Sign in / Sign up

Export Citation Format

Share Document