The molecular mechanism of fullerene-inhibited aggregation of Alzheimer's β-amyloid peptide fragment

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9752-9762 ◽  
Author(s):  
Luogang Xie ◽  
Yin Luo ◽  
Dongdong Lin ◽  
Wenhui Xi ◽  
Xinju Yang ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Inhibitory Effect ◽  
Amyloid Peptide ◽  
Peptide Fragment ◽  
Experiment Study ◽  
Simulation And Experiment ◽  
Β Amyloid ◽  
Combined Simulation ◽  
Β Amyloid Peptide ◽  
Β Sheet

A combined simulation and experiment study demonstrates that fullerenes inhibit the β-sheet formation of Aβ(16–22) and fullerene hexagonal rings play a significant role on the inhibitory effect.

scholarly journals Synthetic Dimeric Aβ(28–40) Mimics the Complex Epitope of Human Anti-Aβ Autoantibodies against Toxic Aβ Oligomers

2013 ◽  
Vol 288 (38) ◽  
pp. 27638-27645 ◽  
Author(s):  
Andreas M. Roeder ◽  
Yvonne Roettger ◽  
Anne Stündel ◽  
Richard Dodel ◽  
Armin Geyer
Keyword(s):  
Conformational Transition ◽  
Amyloid Peptide ◽  
Cd Spectra ◽  
Aβ Oligomers ◽  
Peptide Epitopes ◽  
Β Amyloid ◽  
Covalently Linked ◽  
Β Amyloid Peptide ◽  
Α Helix ◽  
Β Sheet

Covalently linked carboxyl-terminal segments of the β-amyloid peptide (Aβ) were tested for their qualification as minimal conformational epitopes of the naturally occurring human autoantibodies against β-amyloid (nAbs-Aβ). nAbs-Aβ specifically recognize the toxic oligomers of Aβ and not the monomeric or the fibrillar forms of Aβ. The synthetic dimers of Aβ(28–40) described herein mimic the toxic Aβ oligomers but are not kinetic intermediates with uncertain compositions. CD spectra identified a surprisingly rich conformational behavior of selected miniamyloids. We observed a highly cooperative conformational transition of β-sheet to α-helix upon the addition of the helix enforcing co-solvent hexafluoroisopropanol. The CD curves of dimer 9 resembled, in a completely reversible manner, the CD spectra measured during the irreversible fibrillation of the parent Aβ(1–40). Synthetic peptide epitopes with high affinities for nAbs-Aβ are needed to identify the physiological roles of nAbs-Aβ and are promising epitopes for vaccination experiments.

scholarly journals Calmodulin Prevents the Inhibitory Effect of Neurotoxic β-Amyloid Peptide on Synaptosomal Plasma Membrane Ca2+-ATPase

2012 ◽  
Vol 102 (3) ◽  
pp. 508a
Author(s):  
Ana M. Mata ◽  
María Berrocal ◽  
María Vazquez-Hernandez ◽  
M. Rosario Sepulveda
Keyword(s):  
Plasma Membrane ◽  
Inhibitory Effect ◽  
Amyloid Peptide ◽  
Synaptosomal Plasma Membrane ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Conformational Analysis of the β-amyloid Peptide Fragment, β(12–28)

1995 ◽  
Vol 13 (2) ◽  
pp. 229-244 ◽  
Author(s):  
Dimuthu Jayawickrama ◽  
Shana Zink ◽  
David Vander Velde ◽  
Rosemary I. Effiong ◽  
Cynthia K. Larive
Keyword(s):  
Conformational Analysis ◽  
Amyloid Peptide ◽  
Peptide Fragment ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Coralie Di Scala ◽  
Nouara Yahi ◽  
Sonia Boutemeur ◽  
Alessandra Flores ◽  
Léa Rodriguez ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Pore Formation ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Solid State NMR Reveals a pH-dependent Antiparallel β-Sheet Registry in Fibrils Formed by a β-Amyloid Peptide

2004 ◽  
Vol 335 (1) ◽  
pp. 247-260 ◽  
Author(s):  
A.T. Petkova ◽  
G. Buntkowsky ◽  
F. Dyda ◽  
R.D. Leapman ◽  
W.-M. Yau ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Ph Dependent ◽  
Β Amyloid Peptide ◽  
Β Sheet
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